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A6H1P7

- KYNU_FLAPJ

UniProt

A6H1P7 - KYNU_FLAPJ

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Protein
Kynureninase
Gene
kynU, FP2215
Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity.UniRule annotation

Catalytic activityi

L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation
L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051Pyridoxal phosphate; via amide nitrogen By similarity
Binding sitei106 – 1061Pyridoxal phosphate By similarity
Binding sitei218 – 2181Pyridoxal phosphate By similarity
Binding sitei221 – 2211Pyridoxal phosphate By similarity
Binding sitei243 – 2431Pyridoxal phosphate By similarity
Binding sitei274 – 2741Pyridoxal phosphate By similarity
Binding sitei302 – 3021Pyridoxal phosphate By similarity

GO - Molecular functioni

  1. kynureninase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. L-kynurenine catabolic process Source: UniProtKB-UniPathway
  3. anthranilate metabolic process Source: UniProtKB-HAMAP
  4. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  5. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329.
UPA00334; UER00455.

Names & Taxonomyi

Protein namesi
Recommended name:
Kynureninase (EC:3.7.1.3)
Alternative name(s):
L-kynurenine hydrolase
Gene namesi
Name:kynU
Ordered Locus Names:FP2215
OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Taxonomic identifieri402612 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
ProteomesiUP000006394: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 425425KynureninaseUniRule annotation
PRO_0000357006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei244 – 2441N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi402612.FP2215.

Structurei

3D structure databases

ProteinModelPortaliA6H1P7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1364Pyridoxal phosphate binding By similarity

Sequence similaritiesi

Belongs to the kynureninase family.

Phylogenomic databases

eggNOGiCOG3844.
HOGENOMiHOG000242438.
KOiK01556.
OMAiVWDLAHS.
OrthoDBiEOG6N67XP.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPiMF_01970. Kynureninase.
InterProiIPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR14084. PTHR14084. 1 hit.
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
PIRSFiPIRSF038800. KYNU. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01814. kynureninase. 1 hit.

Sequencei

Sequence statusi: Complete.

A6H1P7-1 [UniParc]FASTAAdd to Basket

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MIFQNTLEFA QQLDNQDELK EYKNEFIFPQ HEGKNVIYFT GNSLGLQPKS    50
ARNYVDEVMN DWANLAVEGH FYADKPWWDY QERFANPLSK IVGAKPLEVT 100
VMNTLTVNLH LLMVSFYRPT KKRYKIICEE KAFPSDQYMF QSQVNFHGYK 150
PEDAIVEIKR REGEHNIRLE DILSKIEAVG DELALVLFGG VNYYTGQVFD 200
MKTITEAGHK QGAKVGFDLA HAAGNIKLEL HDWNVDFAAW CSYKYMNSGP 250
GNASGCFVHE KHHSDSNLPR FAGWWGHNKE RRFKMEPTFD PVHGADGWQI 300
SNLPILSLAP YLASVEMFAE VGIEKLIRKR NQITAYLEFI LHEIDKEVKG 350
HFEILTPTNQ EERACQLSVF LHGEGRSLFD YLMKNGVVTD WREPNVIRLA 400
PVPLYCSFED MYNFGQILKK GILEN 425
Length:425
Mass (Da):49,035
Last modified:July 24, 2007 - v1
Checksum:i43111D4A09B97240
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM398681 Genomic DNA. Translation: CAL44271.1.
RefSeqiWP_011964305.1. NC_009613.3.
YP_001297072.1. NC_009613.3.

Genome annotation databases

EnsemblBacteriaiCAL44271; CAL44271; FP2215.
GeneIDi5300761.
KEGGifps:FP2215.
PATRICi21909450. VBIFlaPsy4505_2262.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM398681 Genomic DNA. Translation: CAL44271.1 .
RefSeqi WP_011964305.1. NC_009613.3.
YP_001297072.1. NC_009613.3.

3D structure databases

ProteinModelPortali A6H1P7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402612.FP2215.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL44271 ; CAL44271 ; FP2215 .
GeneIDi 5300761.
KEGGi fps:FP2215.
PATRICi 21909450. VBIFlaPsy4505_2262.

Phylogenomic databases

eggNOGi COG3844.
HOGENOMi HOG000242438.
KOi K01556.
OMAi VWDLAHS.
OrthoDBi EOG6N67XP.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00329 .
UPA00334 ; UER00455 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
HAMAPi MF_01970. Kynureninase.
InterProi IPR000192. Aminotrans_V/Cys_dSase.
IPR010111. Kynureninase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR14084. PTHR14084. 1 hit.
Pfami PF00266. Aminotran_5. 1 hit.
[Graphical view ]
PIRSFi PIRSF038800. KYNU. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01814. kynureninase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JIP02/86 / ATCC 49511.

Entry informationi

Entry nameiKYNU_FLAPJ
AccessioniPrimary (citable) accession number: A6H1P7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 24, 2007
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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