Reviewed, UniProtKB/Swiss-Prot A6H1P4 (KMO_FLAPJ)

Names and origin

Protein names

Recommended name:
    Kynurenine 3-monooxygenase
    EC=1.14.13.9
Alternative name(s):
    Kynurenine 3-hydroxylase

Gene names

Name:	kmo
Ordered Locus Names:	FP2212

Organism

Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511) [Complete proteome] [HAMAP]

Taxonomic identifier

402612 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteria › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Kynurenine 3-monooxygenase		PRO_0000361937

Sequences

	Sequence		Length	Mass (Da)
	A6H1P4-1 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 6792DA4BDCB6185A	FASTA	447	51,302
	10 20 30 40 50 60 MQKSQKIAIV GSGLVGSLLA IYLKKEGHTV HVYDRSPDIR TIQFSGRSIN LAMSNRGWNA 70 80 90 100 110 120 LDGAGVGDKV RHIAIAMEKR AIHIGNQLNF QHYGLQGECI YSISRGVLNR KMIDLAEEAG 130 140 150 160 170 180 AEFFFEQKIW DVNLTDATLQ MGETERGEWT NVSYDMVFGA DGAFSRIRHR MQRQSMFNYS 190 200 210 220 230 240 QDFLNTGYKE LHIPANPDGS YKLDKHSLHI WPRGKYMLIA LPNLDGSFTC TLFMPFEGEN 250 260 270 280 290 300 SFASLDNRQK VEAFFAENLP DTVDVIPDLA EDFFKNPTST LVTMKCFPWT YSDKVALIGD 310 320 330 340 350 360 AAHAIVPFYG QGMNAGFEDI TILYQMMQEY GNDWKTIFSE YEKSRKPDAD AIAELSYRNF 370 380 390 400 410 420 MEMSTKTANE KFLLQKKIER WFASKYPEKW IPLYDRVTFS TRPYSEALAI GDFQETIMQE 430 440 ILKIENIETN WETEEIEHKI IQLLNSK

References

[1]

"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum." Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A. Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AM398681 Genomic DNA. Translation: CAL44268.1.
RefSeq	YP_001297069.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6H1P4.
Genome annotation databases
GeneID	5300731.
GenomeReviews	Gene locus FP2212 in contig AM398681_GR.
KEGG	fps:FP2212.
NMPDR	fig|402612.4.peg.2164.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	LHAIMPS.
Family and domain databases
InterPro	IPR006076. FAD-dep_OxRdtase. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01266. DAO. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_FLAPJ

Accession

Primary (citable) accession number: A6H1P4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	July 24, 2007
Last modified:	November 3, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)