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A6H1D1

- NADK_FLAPJ

UniProt

A6H1D1 - NADK_FLAPJ

Protein

NAD kinase

Gene

nadK

Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (24 Jul 2007)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei74 – 741Proton acceptorUniRule annotation
    Binding sitei79 – 791NADUniRule annotation
    Binding sitei179 – 1791NADUniRule annotation
    Binding sitei214 – 2141NAD; via carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi74 – 752NADUniRule annotation
    Nucleotide bindingi149 – 1502NADUniRule annotation
    Nucleotide bindingi190 – 1956NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:FP2093
    OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
    Taxonomic identifieri402612 [NCBI]
    Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
    ProteomesiUP000006394: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 294294NAD kinasePRO_1000059867Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi402612.FP2093.

    Structurei

    3D structure databases

    ProteinModelPortaliA6H1D1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227222.
    KOiK00858.
    OMAiTHEMLYH.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A6H1D1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIAVFGQFY QNSTSPIIAR LFAFLNQNNI QVVIEEKFAA ILIENKSIAN    50
    TYQKFSSHKD LDKSFEMLIS VGGDGTFLRA TTLVRNSGIP ILGINAGRLG 100
    FLATVQQENI ETFLQLVLEK KYTISKRTLL SLKCASKIEE IKDLNFAMNE 150
    ITVSRKDTTS MITIETYLNG EYLNSYWADG LIISTPTGST GYSMSCGGPI 200
    LTPEANCLVI TPIAPHNLNA RPLVIPDNTE IKLKVSGREE NYLVSLDSRI 250
    ASVKNEDILT IKKTPFKINM IEIPEETFLK TLRNKLLWGE DKRN 294
    Length:294
    Mass (Da):32,907
    Last modified:July 24, 2007 - v1
    Checksum:i753FD1CB278C087F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM398681 Genomic DNA. Translation: CAL44155.1.
    RefSeqiWP_011964192.1. NC_009613.3.
    YP_001296957.1. NC_009613.3.

    Genome annotation databases

    EnsemblBacteriaiCAL44155; CAL44155; FP2093.
    GeneIDi5300141.
    KEGGifps:FP2093.
    PATRICi21909156. VBIFlaPsy4505_2120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM398681 Genomic DNA. Translation: CAL44155.1 .
    RefSeqi WP_011964192.1. NC_009613.3.
    YP_001296957.1. NC_009613.3.

    3D structure databases

    ProteinModelPortali A6H1D1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 402612.FP2093.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAL44155 ; CAL44155 ; FP2093 .
    GeneIDi 5300141.
    KEGGi fps:FP2093.
    PATRICi 21909156. VBIFlaPsy4505_2120.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227222.
    KOi K00858.
    OMAi THEMLYH.
    OrthoDBi EOG6PZXDR.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JIP02/86 / ATCC 49511.

    Entry informationi

    Entry nameiNADK_FLAPJ
    AccessioniPrimary (citable) accession number: A6H1D1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: July 24, 2007
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3