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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:FP2060
OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Taxonomic identifieri402612 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006394 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalUniRule annotationAdd BLAST21
Transmembranei73 – 93HelicalUniRule annotationAdd BLAST21
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21
Transmembranei132 – 152HelicalUniRule annotationAdd BLAST21
Transmembranei214 – 234HelicalUniRule annotationAdd BLAST21
Transmembranei247 – 267HelicalUniRule annotationAdd BLAST21
Transmembranei279 – 299HelicalUniRule annotationAdd BLAST21
Transmembranei305 – 325HelicalUniRule annotationAdd BLAST21
Transmembranei331 – 351HelicalUniRule annotationAdd BLAST21
Transmembranei386 – 406HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000029731 – 409Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST409

Interactioni

Protein-protein interaction databases

STRINGi402612.FP2060.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275122.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

A6H198-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYYLFQYLD KYFDFPGAGV FQYITFRSAL AIIMSLLIST IFGKRVISYL
60 70 80 90 100
SRLQVGETVR ELGLEGQTQK AGTPTMGGLI IIFSTLLPVL LLAKLNNIYI
110 120 130 140 150
ILLIVTTIWM GAIGFLDDYI KIFKKDKAGL KGIFKVIGQV GLGLIVGTTL
160 170 180 190 200
YFHQDVTIRE NISKNKIEVY STQKGANTLS SDKKSTATTI PFFKNNEFDY
210 220 230 240 250
AELLAWTGDG YRNYAWLIFI PIVIFIITAV SNGANLTDGI DGLAAGTSAI
260 270 280 290 300
SVIAIGVFTF VSGNVIFSNY LNIMFIPNSG EMTVFIAAFV GALIGFLWYN
310 320 330 340 350
SYPAAVFMGD TGSLTIGGII AVLAIAVRKE MLIPVFCGIF LAENLSVVLQ
360 370 380 390 400
VSYFKYTKKR FGEGRRIFLM SPLHHHYQKK GYHESKIVTR FWIVGILLAI

VSIVTLKLR
Length:409
Mass (Da):45,376
Last modified:July 24, 2007 - v1
Checksum:i54BAA88D19E2C624
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM398681 Genomic DNA. Translation: CAL44122.1.
RefSeqiWP_011964159.1. NC_009613.3.
YP_001296924.1. NC_009613.3.

Genome annotation databases

EnsemblBacteriaiCAL44122; CAL44122; FP2060.
GeneIDi5299891.
KEGGifps:FP2060.
PATRICifig|402612.5.peg.2087.

Similar proteinsi

Entry informationi

Entry nameiMRAY_FLAPJ
AccessioniPrimary (citable) accession number: A6H198
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 24, 2007
Last modified: June 7, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families