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A6H197 (A6H197_FLAPJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase HAMAP MF_00639 RuleBase RU003664
EC=6.3.2.9 HAMAP MF_00639 RuleBase RU003664
Alternative name(s):
D-glutamic acid-adding enzyme HAMAP MF_00639
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase HAMAP MF_00639
Gene names
Name:murD HAMAP MF_00639 EMBL CAL44121.1
Ordered Locus Names:FP2059
OrganismFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Taxonomic identifier402612 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length443 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) By similarity. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanine + glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762

Subcellular location

Cytoplasm By similarity HAMAP MF_00639 RuleBase RU003664 SAAS SAAS005762.

Sequence similarities

Belongs to the MurCDEF family. HAMAP MF_00639 RuleBase RU003630

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding108 – 1147ATP By similarity HAMAP MF_00639

Sequences

Sequence LengthMass (Da)Tools
A6H197 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 05678313979BEAEC

FASTA44349,703
        10         20         30         40         50         60 
MRLVILGGGE SGVGTAILGK KKGYDVFVSD FGKIKNNYKE ILILNKIKFE DEQHTEDLIL 

        70         80         90        100        110        120 
NADVVMKSPG IPDKSPIVKK LKEKNIPVIS EIEFTAPFTN AKTIGITGSN GKTTTTMLVY 

       130        140        150        160        170        180 
HLLKQGGLNV GLAGNIGKSF AWQVSEDTHD FYVLELSSFQ LDGIQKYKPH IAIITNISPD 

       190        200        210        220        230        240 
HLDRYDYQYE KYIESKFRIT MNQTEEDYLI YDADDQAINN WLKNNKTKAQ LVPFSLTKQF 

       250        260        270        280        290        300 
EFGAYEANNN ININTNNDPF VMQTSELSLE GKHNVKNALA ATSVAQLLKI RKATIRESLA 

       310        320        330        340        350        360 
DFQGVEHRLE KVLKIQNVQY INDSKATNVN ATFYALDSMT SPTIWIVGGV DKGNDYSELM 

       370        380        390        400        410        420 
ELVNKNVKTI ICLGVDNKKI IDAFSNVVDE LIEVSTMTDA VRQAYKMAEK GDTVLLSPAC 

       430        440 
ASFDLFENYE DRGRQFKQAV QNL

« Hide

References

[1]"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum."
Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A.
Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM398681 Genomic DNA. Translation: CAL44121.1.
RefSeqYP_001296923.1. NC_009613.1.

3D structure databases

ProteinModelPortalA6H197.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6H197.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5300233.
GenomeReviewsGene locus FP2059 in contig AM398681_GR.
KEGGfps:FP2059.
NMPDRfig|402612.4.peg.1993.
PATRIC21909088. VBIFlaPsy4505_2086.

Phylogenomic databases

eggNOGCOG0771.
HOGENOMHBG750024.
OMAACASWDM.
ProtClustDBCLSK823532.

Family and domain databases

HAMAPMF_00639. MurD.
[Tree]
InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK01925.
PANTHERPTHR23135:SF2. PTHR23135:SF2. 1 hit.
PfamPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01087. MurD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6H197_FLAPJ
AccessionPrimary (citable) accession number: A6H197
Entry history
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: December 14, 2011
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info