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A6H185

- PNP_FLAPJ

UniProt

A6H185 - PNP_FLAPJ

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, FP2046
Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881Magnesium By similarity
Metal bindingi494 – 4941Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:FP2046
OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Taxonomic identifieri402612 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
ProteomesiUP000006394: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 711711Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329648Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402612.FP2046.

Structurei

3D structure databases

ProteinModelPortaliA6H185.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61763KH
Add
BLAST
Domaini627 – 69872S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6H185-1 [UniParc]FASTAAdd to Basket

« Hide

MIPQLFVESI DLGDGRNITI ETGRLAKQAD GSVVVRIGKT VILGTVVSSR    50
KATPGIDFLP LTVDYREKFA AAGRFPGGFF KREARPSDSE VLTMRLVDRV 100
LRPLFPSDYH AEVQVMIQLM SHDEEVMPDA LAGLAASAAL ALSDIPFETL 150
ISEARVGRID GKFIINPSRA QLELSDIDMM IGASTDSIAM VEGEMKEISE 200
AEMLEAIKFA HEHIKVQIAA QERLAAAFGK KEVRTYEKEK SDDAIYAKVK 250
EAAYDKIYNI AKVGSAKQER TAAFDAVKEE VKALFTEEEL AENGDLVSKY 300
FYKTNKEAVR NVTLDLGTRL DGRKTTEIRP IWCEVDYLPS VHGSALFTRG 350
ETQALATATL GTSREANQID SPSQQGEEKF YLHYNFPPFS TGEARPLRGT 400
SRREVGHGNL AQRALKNMIP ADCPYTIRVV SEVLESNGSS SMATVCAGTL 450
SLMDAGIQMI RPVSGIAMGL ITDGERFAVL SDILGDEDHL GDMDFKVTGT 500
SEGITACQMD IKIDGLKYEI MEAALAQARD GRLHILNILT ETLATPKVDV 550
KAYAPKIIMR TIPGNFIGAL IGPGGKVIQE LQKATGTTIV INEVDEMGVV 600
EILGTDPAGI EAVLAKIESI TFKPQIGEAY EVKVIKMLDF GAVVEYTAVP 650
GNEVLLHVSE LAWERTENVT DVVNMGDVFM VKYLGLDPKT RKEKVSRKAL 700
LPRPPREEKK E 711
Length:711
Mass (Da):77,852
Last modified:July 24, 2007 - v1
Checksum:iFE66D74CEBD85279
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM398681 Genomic DNA. Translation: CAL44109.1.
RefSeqiYP_001296911.1. NC_009613.3.

Genome annotation databases

EnsemblBacteriaiCAL44109; CAL44109; FP2046.
GeneIDi5300252.
KEGGifps:FP2046.
PATRICi21909058. VBIFlaPsy4505_2072.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM398681 Genomic DNA. Translation: CAL44109.1 .
RefSeqi YP_001296911.1. NC_009613.3.

3D structure databases

ProteinModelPortali A6H185.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402612.FP2046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL44109 ; CAL44109 ; FP2046 .
GeneIDi 5300252.
KEGGi fps:FP2046.
PATRICi 21909058. VBIFlaPsy4505_2072.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JIP02/86 / ATCC 49511.

Entry informationi

Entry nameiPNP_FLAPJ
AccessioniPrimary (citable) accession number: A6H185
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 24, 2007
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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