A6H0G2 (RLMF_FLAPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ribosomal RNA large subunit methyltransferase F
EC=2.1.1.181

Alternative name(s):
23S rRNA mA1618 methyltransferase
rRNA adenine N-6-methyltransferase

Gene names

Name:	rlmF
Ordered Locus Names:	FP1768

Organism

Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)

Taxonomic identifier

402612 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically methylates the adenine in position 1618 of 23S rRNA By similarity. HAMAP MF_01848
Catalytic activity	S-adenosyl-L-methionine + adenine(1618) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(1618) in 23S rRNA. HAMAP MF_01848
Subcellular location	Cytoplasm Potential HAMAP MF_01848.
Sequence similarities	Belongs to the methyltransferase superfamily. METTL16/rlmF family.

Ontologies

Keywords
Biological process	rRNA processing
Cellular component	Cytoplasm
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	rRNA (adenine-N6-)-methyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Ribosomal RNA large subunit methyltransferase F HAMAP MF_01848		PRO_0000349917

Sequences

	Sequence		Length	Mass (Da)
	A6H0G2 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 018D6FA89AF2D3E3	FASTA	314	35,612
	10 20 30 40 50 60 MKAKIVPEKT NLHPRNLHKF GYDFEALTTC SSELKNHVFT NEYDTQTINF SNPEAVKALN 70 80 90 100 110 120 NALLIAYYNI KNWGIPQDYL CPPIPGRADY LHYIADLLAT TNNQIIPEGE NVIGLDIGIG 130 140 150 160 170 180 ANCIYPIIGN AIYDWSFVGT DIDEKAIQNC KKIIENNPKL IDAISLQQQV ESRFIFKNII 190 200 210 220 230 240 LTDDKFAFTI CNPPFHNSAA EATKSSARKV NNLQEIRTKN PVLNFGGQNT ELWCDGGEIG 250 260 270 280 290 300 FITQMIYESA KYPMQVLWFT TLVSKRENLS SIYKTLNKVS AVEIKTIDMA QGQKNSRIVA 310 WTFLSELQQK AWRF

References

[1]

"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum." Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A. Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM398681 Genomic DNA. Translation: CAL43835.1.
RefSeq	YP_001296642.1. NC_009613.1.
3D structure databases
ProteinModelPortal	A6H0G2.
ModBase	Search...
Protein-protein interaction databases
STRING	A6H0G2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5300033.
GenomeReviews	Gene locus FP1768 in contig AM398681_GR.
KEGG	fps:FP1768.
NMPDR	fig|402612.4.peg.1706.
PATRIC	21908480. VBIFlaPsy4505_1787.
Phylogenomic databases
eggNOG	COG3129.
HOGENOM	HBG747880.
OMA	DFANPEA.
ProtClustDB	PRK11727.
Family and domain databases
HAMAP	MF_01848. 23SrRNA_methyltr_F. [Tree]
InterPro	IPR016909. rRNA_lsu_methyltransferase_F. IPR010286. SAM-Mtase_prd. [Graphical view]
KO	K06970.
PANTHER	PTHR13393. DUF890. 1 hit.
Pfam	PF05971. Methyltransf_10. 1 hit. [Graphical view]
PIRSF	PIRSF029038. Mtase_YbiN_prd. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RLMF_FLAPJ

Accession

Primary (citable) accession number: A6H0G2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program