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A6H0E7

- DEF_FLAPJ

UniProt

A6H0E7 - DEF_FLAPJ

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Protein

Peptide deformylase

Gene

def

Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi105 – 1051IronUniRule annotation
Metal bindingi147 – 1471IronUniRule annotation
Active sitei148 – 1481UniRule annotation
Metal bindingi151 – 1511IronUniRule annotation

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotation (EC:3.5.1.88UniRule annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:FP1753
OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Taxonomic identifieri402612 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
ProteomesiUP000006394: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 194194Peptide deformylasePRO_0000301033Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi402612.FP1753.

Structurei

3D structure databases

ProteinModelPortaliA6H0E7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243509.
KOiK01462.
OMAiEETGEEW.
OrthoDBiEOG664CMF.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

A6H0E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MILPIVGYGD PVLRKVCEEI TKDYINLEET IANMYETMYN ACGVGLAAPQ
60 70 80 90 100
VGLPIRLFIV DADPFSDSDD ISKEEAAALK GFKKTFINAK MLKEEGEEWS
110 120 130 140 150
FSEGCLSIPD VREDVYRNPN ITIEYYDENF NKKTEEYNGL IARVIQHEYD
160 170 180 190
HIEGVLFTDK ITVFKKQFIK KKLQNIMEGK ARPDYRMKLV PKKR
Length:194
Mass (Da):22,389
Last modified:July 24, 2007 - v1
Checksum:i21B30F28E66C009F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM398681 Genomic DNA. Translation: CAL43820.1.
RefSeqiWP_011963863.1. NC_009613.3.
YP_001296627.1. NC_009613.3.

Genome annotation databases

EnsemblBacteriaiCAL43820; CAL43820; FP1753.
GeneIDi5300112.
KEGGifps:FP1753.
PATRICi21908450. VBIFlaPsy4505_1772.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM398681 Genomic DNA. Translation: CAL43820.1 .
RefSeqi WP_011963863.1. NC_009613.3.
YP_001296627.1. NC_009613.3.

3D structure databases

ProteinModelPortali A6H0E7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 402612.FP1753.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAL43820 ; CAL43820 ; FP1753 .
GeneIDi 5300112.
KEGGi fps:FP1753.
PATRICi 21908450. VBIFlaPsy4505_1772.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243509.
KOi K01462.
OMAi EETGEEW.
OrthoDBi EOG664CMF.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JIP02/86 / ATCC 49511.

Entry informationi

Entry nameiDEF_FLAPJ
AccessioniPrimary (citable) accession number: A6H0E7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 24, 2007
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3