A6GYW8 (DNAA_FLAPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	FP1208

Organism

Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)

Taxonomic identifier

402612 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length	478 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 478	478	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_1000048644
Regions
	Nucleotide binding	183 – 190	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	A6GYW8 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: D65E0701D5CE51F8	FASTA	478	55,019
	10 20 30 40 50 60 MHTMNKTAES VWDNCLSFIK DNIQEQAYKT WFEPIKSVEL TDNALYIQVP SKFFYEWLEE 70 80 90 100 110 120 HYVKLLKVAL TKELGKNAKL LYKIKMENTY GNKLPFTEQL PSAHRSPVRT QEIDVPVQQK 130 140 150 160 170 180 NPELRNPFII PGIRNLKIES QLNANYSFDN FLEGDSNRLA RSAGMAVANK PGGTSFNPLL 190 200 210 220 230 240 IFGGVGLGKT HLAHAIGVEV KEKYPEKTVL YISAEIFTQQ YIESVKKNNR NDFIHFYQLI 250 260 270 280 290 300 DVLIIDDVQF LSGKTGTQDV FFHIFNYLHQ NGKQVILTSD KAPVDMQDIE QRLLSRFKWG 310 320 330 340 350 360 LSAEIHQPDY ETRISILKNI LYRDGVEMPE EIIEYVARNI KSNVRELEGA IISLIAQSSF 370 380 390 400 410 420 NKKEVTLELA KQVVEKFVKN VKREVSIDYI QKVVSDYFQL DLEVLQSKTR KRHVVQARQL 430 440 450 460 470 AMFFAKRYTK ASLANIGSQI GDRDHATVLH ACKTVDNLVT TDKQFKKFVD DINKKLSL

References

[1]

"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum." Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A. Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM398681 Genomic DNA. Translation: CAL43291.1.
RefSeq	YP_001296102.1. NC_009613.1.
3D structure databases
ProteinModelPortal	A6GYW8.
ModBase	Search...
Protein-protein interaction databases
STRING	A6GYW8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5299442.
GenomeReviews	Gene locus FP1208 in contig AM398681_GR.
KEGG	fps:FP1208.
NMPDR	fig|402612.4.peg.1170.
PATRIC	21907322. VBIFlaPsy4505_1222.
Phylogenomic databases
eggNOG	COG0593.
HOGENOM	HBG695666.
OMA	CHTLNAL.
ProtClustDB	PRK00149.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_FLAPJ

Accession

Primary (citable) accession number: A6GYW8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program