A6GYI6 (MSCL_FLAPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	FP1065

Organism

Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)

Taxonomic identifier

402612 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. HAMAP MF_00115
Subunit structure	Homopentamer By similarity. HAMAP MF_00115
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00115.
Sequence similarities	Belongs to the MscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Ionic channel
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_1000071346
Regions
	Transmembrane	9 – 29	21	Helical; Potential
	Transmembrane	44 – 66	23	Helical; Potential
	Transmembrane	83 – 103	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	A6GYI6 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 6E41A88DD80C7521	FASTA	138	14,399
	10 20 30 40 50 60 MGFFADFKAS LMKGDVLSLA TAVVIGGAFG KIVGSAVDDI IMPIVGVLTG GVDFTTKFIA 70 80 90 100 110 120 LNGQSYADLA AAKTAGAACL TYGNLVQAII NFIIISFFIF VVLRAAEKAK KKEEAAPTAP 130 AGPSQEELLT QIRDLLKK

References

[1]

"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum." Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A. Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM398681 Genomic DNA. Translation: CAL43159.1.
RefSeq	YP_001295970.1. NC_009613.1.
3D structure databases
ProteinModelPortal	A6GYI6.
ModBase	Search...
Protein-protein interaction databases
STRING	A6GYI6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5299887.
GenomeReviews	Gene locus FP1065 in contig AM398681_GR.
KEGG	fps:FP1065.
NMPDR	fig|402612.4.peg.1035.
PATRIC	21907016. VBIFlaPsy4505_1079.
Phylogenomic databases
eggNOG	COG1970.
HOGENOM	HBG727604.
OMA	IKATRCP.
ProtClustDB	CLSK851869.
Family and domain databases
HAMAP	MF_00115. MscL. [Tree]
InterPro	IPR001185. MS_channel. [Graphical view]
KO	K03282.
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
SUPFAM	SSF81330. MS_channel. 1 hit.
TIGRFAMs	TIGR00220. MscL. 1 hit.
PROSITE	PS01327. MSCL. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_FLAPJ

Accession

Primary (citable) accession number: A6GYI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program