A6GYA2 (KDSB_FLAPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferase
EC=2.7.7.38

Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthase
Short name=CKS
Short name=CMP-KDO synthase

Gene names

Name:	kdsB
Ordered Locus Names:	FP0981

Organism

Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)

Taxonomic identifier

402612 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length	241 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria By similarity. HAMAP MF_00057
Catalytic activity	CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. HAMAP MF_00057
Pathway	Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1. HAMAP MF_00057 Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis. HAMAP MF_00057
Subcellular location	Cytoplasm Potential HAMAP MF_00057.
Sequence similarities	Belongs to the KdsB family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-deoxy-manno-octulosonate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 241	241	3-deoxy-manno-octulosonate cytidylyltransferase HAMAP MF_00057		PRO_1000116890

Sequences

	Sequence		Length	Mass (Da)
	A6GYA2 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 667CBDE41172701C	FASTA	241	27,573
	10 20 30 40 50 60 MKIIAVIPAR YASTRFPAKL MQDLGGKTVI LRTYQAAVET NLFDDVFVVT DSELIYNEII 70 80 90 100 110 120 TNAGKAIMSI KEHESGSDRI AEAIQNLEVD IVVNVQGDEP FINKEPLEEV IQVFRNDTHK 130 140 150 160 170 180 KVDLASLMRN ITHKNDIQNP NNVKVIVDQK GFALYFSRSV IPYPREENVG VRYMQHIGIY 190 200 210 220 230 240 AFRKQALLDF YHLPMLSLEA SEKLEQLRYL EYGKRIKMIE TTHVGIGIDT LEDLEKARSM L

References

[1]

"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum." Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A. Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM398681 Genomic DNA. Translation: CAL43075.1.
RefSeq	YP_001295888.1. NC_009613.1.
3D structure databases
ProteinModelPortal	A6GYA2.
ModBase	Search...
Protein-protein interaction databases
STRING	A6GYA2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5300362.
GenomeReviews	Gene locus FP0981 in contig AM398681_GR.
KEGG	fps:FP0981.
NMPDR	fig|402612.4.peg.955.
PATRIC	21906844. VBIFlaPsy4505_0993.
Phylogenomic databases
eggNOG	COG1212.
HOGENOM	HBG637773.
OMA	INVQADE.
ProtClustDB	CLSK851559.
Family and domain databases
HAMAP	MF_00057. CMP-KDO_synth. [Tree]
InterPro	IPR003329. Cytidylyl_trans. IPR004528. KdsB. [Graphical view]
KO	K00979.
PANTHER	PTHR21485:SF4. PTHR21485:SF4. 1 hit.
Pfam	PF02348. CTP_transf_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00466. KdsB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

KDSB_FLAPJ

Accession

Primary (citable) accession number: A6GYA2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program