Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA2

Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

GlycolysisSAAS annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdA2Imported
Ordered Locus Names:FP0706Imported
OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)Imported
Taxonomic identifieri402612 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006394 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi402612.FP0706.

Structurei

3D structure databases

ProteinModelPortaliA6GXI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 323321FAD/NAD-binding_domInterPro annotationAdd
BLAST
Domaini343 – 451109Pyr_redox_dimInterPro annotationAdd
BLAST

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiHAINKHN.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A6GXI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDIIVLGS GPGGYVTAIR ASQLGFKVAV VEKENLGGVC LNWGCIPTKA
60 70 80 90 100
LLKSAQVFDY LKHASDYGLT VKEFDKDFSA VVSRSRNVAG DMSKGVQFLM
110 120 130 140 150
KKNKIDVIDG FGKLKSGKKI DVTDKDNKVT EYSADHIIIA TGARSRELPN
160 170 180 190 200
LPQDGVKVIG YRQAMTLPTQ PKSMIIVGSG AIGVEFAHFY NAMGTEVTIV
210 220 230 240 250
EFMPNIVPVE DEDISKQMER SMKKAGVKIM TSSSVERIDT SGSGVKAYVK
260 270 280 290 300
TAKGEEILEA DILLSAVGIK TNIENIGLEE VGISTDKDKI LVNAFSQTNI
310 320 330 340 350
PGYYAIGDVT PGQALAHVAS AEGINCVEKI AGLHVDPIDY GNVPGCTYAT
360 370 380 390 400
PEIASVGLTE KQAKEKGYEL KIGKFPFSAS GKAKASGTPD GFVKVIFDAK
410 420 430 440 450
YGEWLGCHMI GAGVTDMIAE AVVARKLETT GHEILKAIHP HPTMSEAVME
460
AVADAYGEVI HL
Length:462
Mass (Da):49,444
Last modified:July 24, 2007 - v1
Checksum:i2D7F7CB1CB09A2B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM398681 Genomic DNA. Translation: CAL42809.1.
RefSeqiWP_011962865.1. NC_009613.3.
YP_001295625.1. NC_009613.3.

Genome annotation databases

EnsemblBacteriaiCAL42809; CAL42809; FP0706.
GeneIDi5300706.
KEGGifps:FP0706.
PATRICi21906288. VBIFlaPsy4505_0723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM398681 Genomic DNA. Translation: CAL42809.1.
RefSeqiWP_011962865.1. NC_009613.3.
YP_001295625.1. NC_009613.3.

3D structure databases

ProteinModelPortaliA6GXI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi402612.FP0706.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL42809; CAL42809; FP0706.
GeneIDi5300706.
KEGGifps:FP0706.
PATRICi21906288. VBIFlaPsy4505_0723.

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiHAINKHN.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 2 hits.
InterProiIPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA6GXI6_FLAPJ
AccessioniPrimary (citable) accession number: A6GXI6
Entry historyi
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: September 7, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.