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Protein

Dihydrolipoyl dehydrogenase

Gene

lpdA2

Organism
Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Miscellaneous

The active site is a redox-active disulfide bond.UniRule annotation

Catalytic activityi

Protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH.UniRule annotation

Cofactori

FADUniRule annotationNote: Binds 1 FAD per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandFADUniRule annotation, Flavoprotein, NADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydrolipoyl dehydrogenaseUniRule annotation (EC:1.8.1.4UniRule annotation)
Gene namesi
Name:lpdA2Imported
Ordered Locus Names:FP0706Imported
OrganismiFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)Imported
Taxonomic identifieri402612 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium
Proteomesi
  • UP000006394 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi402612.FP0706.

Structurei

3D structure databases

ProteinModelPortaliA6GXI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 323FAD/NAD-binding_domInterPro annotationAdd BLAST321
Domaini343 – 451Pyr_redox_dimInterPro annotationAdd BLAST109

Sequence similaritiesi

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.UniRule annotation

Keywords - Domaini

Redox-active centerUniRule annotation

Phylogenomic databases

eggNOGiENOG4107QN2. Bacteria.
COG1249. LUCA.
HOGENOMiHOG000276708.
KOiK00382.
OMAiTMSEAVM.
OrthoDBiPOG091H0239.

Family and domain databases

Gene3Di3.30.390.30. 1 hit.
3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR023753. FAD/NAD-binding_dom.
IPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR006258. Lipoamide_DH.
IPR001100. Pyr_nuc-diS_OxRdtase.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR012999. Pyr_OxRdtase_I_AS.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
PIRSFiPIRSF000350. Mercury_reductase_MerA. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.
SSF55424. SSF55424. 1 hit.
TIGRFAMsiTIGR01350. lipoamide_DH. 1 hit.
PROSITEiView protein in PROSITE
PS00076. PYRIDINE_REDOX_1. 1 hit.

Sequencei

Sequence statusi: Complete.

A6GXI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYDIIVLGS GPGGYVTAIR ASQLGFKVAV VEKENLGGVC LNWGCIPTKA
60 70 80 90 100
LLKSAQVFDY LKHASDYGLT VKEFDKDFSA VVSRSRNVAG DMSKGVQFLM
110 120 130 140 150
KKNKIDVIDG FGKLKSGKKI DVTDKDNKVT EYSADHIIIA TGARSRELPN
160 170 180 190 200
LPQDGVKVIG YRQAMTLPTQ PKSMIIVGSG AIGVEFAHFY NAMGTEVTIV
210 220 230 240 250
EFMPNIVPVE DEDISKQMER SMKKAGVKIM TSSSVERIDT SGSGVKAYVK
260 270 280 290 300
TAKGEEILEA DILLSAVGIK TNIENIGLEE VGISTDKDKI LVNAFSQTNI
310 320 330 340 350
PGYYAIGDVT PGQALAHVAS AEGINCVEKI AGLHVDPIDY GNVPGCTYAT
360 370 380 390 400
PEIASVGLTE KQAKEKGYEL KIGKFPFSAS GKAKASGTPD GFVKVIFDAK
410 420 430 440 450
YGEWLGCHMI GAGVTDMIAE AVVARKLETT GHEILKAIHP HPTMSEAVME
460
AVADAYGEVI HL
Length:462
Mass (Da):49,444
Last modified:July 24, 2007 - v1
Checksum:i2D7F7CB1CB09A2B2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM398681 Genomic DNA. Translation: CAL42809.1.
RefSeqiWP_011962865.1. NC_009613.3.
YP_001295625.1. NC_009613.3.

Genome annotation databases

EnsemblBacteriaiCAL42809; CAL42809; FP0706.
GeneIDi5300706.
KEGGifps:FP0706.
PATRICifig|402612.5.peg.723.

Similar proteinsi

Entry informationi

Entry nameiA6GXI6_FLAPJ
AccessioniPrimary (citable) accession number: A6GXI6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: September 27, 2017
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported