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A6GXE4 (A6GXE4_FLAPJ) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208 EMBL CAL42767.1
Ordered Locus Names:FP0663
OrganismFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)
Taxonomic identifier402612 [NCBI]
Taxonomic lineageBacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length215 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region126 – 13495-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site10015-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10415-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site10615-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1301Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
A6GXE4 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 1B373F5C62A34C1A

FASTA21523,857
        10         20         30         40         50         60 
MIFNKDTASK TAELLLQINA IKLNSENPFT WASGWKSPIY CDNRVILSFP AIRNYIRDEF 

        70         80         90        100        110        120 
SKNIEKQFGK PDVIAGVATG AIGIGILVAE SLGLPFVYVR PEAKKHGRLN QVEGFLQKGQ 

       130        140        150        160        170        180 
NVIVVEDLIS TGNSSLLAVE ALRNEGANVK GMAAVFSYGF QVATDNFANA KVDLFTLSNY 

       190        200        210 
ESLLELAVAK EYITKKEQNL LQEWRKNPSE WNVVI

« Hide

References

[1]"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum."
Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A.
Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AM398681 Genomic DNA. Translation: CAL42767.1.
RefSeqYP_001295583.1. NC_009613.1.

3D structure databases

ProteinModelPortalA6GXE4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA6GXE4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5299875.
GenomeReviewsGene locus FP0663 in contig AM398681_GR.
KEGGfps:FP0663.
NMPDRfig|402612.4.peg.655.
PATRIC21906200. VBIFlaPsy4505_0680.

Phylogenomic databases

eggNOGCOG0461.
HOGENOMHBG404341.
OMALPMTYVR.
ProtClustDBPRK00455.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA6GXE4_FLAPJ
AccessionPrimary (citable) accession number: A6GXE4
Entry history
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info