A6GX95 (ACCA_FLAPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha
Short name=ACCase subunit alpha
Short name=Acetyl-CoA carboxylase carboxyltransferase subunit alpha
EC=6.4.1.2

Gene names

Name:	accA
Ordered Locus Names:	FP0613

Organism

Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)

Taxonomic identifier

402612 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length	317 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA By similarity. HAMAP MF_00823
Catalytic activity	ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. HAMAP MF_00823
Pathway	Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. HAMAP MF_00823
Subunit structure	Acetyl-CoA carboxylase is an heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD) By similarity.
Subcellular location	Cytoplasm By similarity HAMAP MF_00823.
Sequence similarities	Belongs to the AccA family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	acetyl-CoA carboxylase complex Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetyl-CoA carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 317	317	Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha HAMAP MF_00823		PRO_1000072882

Sequences

	Sequence		Length	Mass (Da)
	A6GX95 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 5B51F85CF843666E	FASTA	317	35,769
	10 20 30 40 50 60 MEYLDFELPI KELLEQLDKC QIIGTESNVD VTETCKQISQ KLEDTKKDIY GNLTAWQRVQ 70 80 90 100 110 120 LSRHPSRPYT LEHITNLTKG TFLELFGDRN FKDDKAMIGG LGKIGDQSFM FVGQQKGINT 130 140 150 160 170 180 KMRQFRNFGM PNPEGYRKAL RLMKMAEKFN IPVVTLIDTP GAFPGIEAEE RGQGEAIARN 190 200 210 220 230 240 ILEMARLKVP IICVIIGEGA SGGALGIGVG DRVLMMENTW YSVISPESCS SILWKSWEYK 250 260 270 280 290 300 EQAAEALKLT SADMKRQKIV DDIIPEPLGG AHYDKATAFK TVEEYILKAF NELKDLSTTD 310 LVAQRMDKYS KMGEYNE

References

[1]

"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum." Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A. Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM398681 Genomic DNA. Translation: CAL42718.1.
RefSeq	YP_001295534.1. NC_009613.1.
3D structure databases
ProteinModelPortal	A6GX95.
ModBase	Search...
Protein-protein interaction databases
STRING	A6GX95.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5300636.
GenomeReviews	Gene locus FP0613 in contig AM398681_GR.
KEGG	fps:FP0613.
NMPDR	fig|402612.4.peg.606.
PATRIC	21906090. VBIFlaPsy4505_0626.
Phylogenomic databases
eggNOG	COG0825.
HOGENOM	HBG286557.
OMA	GRDTKDN.
ProtClustDB	PRK05724.
Family and domain databases
HAMAP	MF_00823. AcetylCoA_CT_alpha. [Tree]
InterPro	IPR001095. Acetyl_CoA_COase_a_su. IPR011763. COA_CT_C. [Graphical view]
KO	K01962.
PANTHER	PTHR22855:SF3. Ac-CoA_carboxylA. 1 hit.
Pfam	PF03255. ACCA. 1 hit. [Graphical view]
PRINTS	PR01069. ACCCTRFRASEA.
TIGRFAMs	TIGR00513. AccA. 1 hit.
PROSITE	PS50989. COA_CT_CTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACCA_FLAPJ

Accession

Primary (citable) accession number: A6GX95

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program