A6GW62 (A6GW62_FLAPJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Lipoprotein signal peptidase HAMAP MF_00161
EC=3.4.23.36 HAMAP MF_00161

Alternative name(s):
Prolipoprotein signal peptidase HAMAP MF_00161
Signal peptidase II HAMAP MF_00161

Gene names

Name:	lspA HAMAP MF_00161 EMBL CAL42335.1
Ordered Locus Names:	FP0219

Organism

Flavobacterium psychrophilum (strain JIP02/86 / ATCC 49511)

Taxonomic identifier

402612 [NCBI]

Taxonomic lineage

Bacteria › Bacteroidetes › Flavobacteriia › Flavobacteriales › Flavobacteriaceae › Flavobacterium

Protein attributes

Sequence length	197 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP MF_00161 SAAS SAAS001872
Catalytic activity	Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161 SAAS SAAS001872
Pathway	Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161 SAAS SAAS001872
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00161.
Sequence similarities	Belongs to the peptidase A8 family. HAMAP MF_00161 RuleBase RU004181

Ontologies

Keywords
Cellular component	Cell inner membrane HAMAP MF_00161 Cell membrane Membrane
Domain	Transmembrane Transmembrane helix HAMAP MF_00161 SAAS SAAS001872
Molecular function	Aspartyl protease HAMAP MF_00161 SAAS SAAS001872 Hydrolase Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aspartic-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Transmembrane	6 – 26	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	64 – 84	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	92 – 112	21	Helical; By similarity HAMAP MF_00161
	Transmembrane	168 – 188	21	Helical; By similarity HAMAP MF_00161
Sites
	Active site	109	1	By similarity HAMAP MF_00161
	Active site	177	1	By similarity HAMAP MF_00161

Sequences

	Sequence		Length	Mass (Da)
	A6GW62 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 57EF7125577DE73C	FASTA	197	22,350
	10 20 30 40 50 60 MNLKKAYFIV FLVLLIDQIS KIYVKTHFVL HQEVPVFSWF KILFIENEGM AWGVEIPGIY 70 80 90 100 110 120 GKLTLTLFRI LAVGGIGYWL WDAVKKRSST VLVIAISLIM AGAFGNIIDS VFYGKIFNDS 130 140 150 160 170 180 TYSLATLFSE QPYGSWFYGK VVDMLYFPIW EGNLPTWLPV WGGNHFTFFN AIFNVADMAI 190 STGVGILIVF NKKAFAK

References

[1]

"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum." Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A. Nat. Biotechnol. 25:763-769(2007) [PubMed: 17592475] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM398681 Genomic DNA. Translation: CAL42335.1.
RefSeq	YP_001295155.1. NC_009613.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A6GW62.
Protein family/group databases
MEROPS	A08.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5298962.
GenomeReviews	Gene locus FP0219 in contig AM398681_GR.
KEGG	fps:FP0219.
NMPDR	fig|402612.4.peg.217.
PATRIC	21905274. VBIFlaPsy4505_0228.
Phylogenomic databases
eggNOG	NOG78647.
HOGENOM	HBG724422.
OMA	HGKVVDM.
ProtClustDB	PRK14788.
Family and domain databases
HAMAP	MF_00161. LspA. [Tree]
InterPro	IPR001872. Peptidase_A8. [Graphical view]
KO	K03101.
Pfam	PF01252. Peptidase_A8. 1 hit. [Graphical view]
PRINTS	PR00781. LIPOSIGPTASE.
ProtoNet	Search...

Entry information

Entry name

A6GW62_FLAPJ

Accession

Primary (citable) accession number: A6GW62

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)