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A6GW45 (RNC_FLAPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonuclease 3

EC=3.1.26.3
Alternative name(s):
Ribonuclease III
Short name=RNase III
Gene names
Name:rnc
Ordered Locus Names:FP0202
OrganismFlavobacterium psychrophilum (strain JIP02/86 / ATCC 49511) [Reference proteome] [HAMAP]
Taxonomic identifier402612 [NCBI]
Taxonomic lineageBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon By similarity. HAMAP-Rule MF_00104

Catalytic activity

Endonucleolytic cleavage to 5'-phosphomonoester. HAMAP-Rule MF_00104

Cofactor

Mg2+ By similarity. HAMAP-Rule MF_00104

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00104

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00104.

Sequence similarities

Contains 1 DRBM (double-stranded RNA-binding) domain.

Contains 1 RNase III domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 246246Ribonuclease 3 HAMAP-Rule MF_00104
PRO_0000416604

Regions

Domain20 – 145126RNase III
Domain173 – 24169DRBM

Sites

Active site661 Potential
Active site1341 By similarity
Metal binding621Magnesium By similarity
Metal binding1311Magnesium By similarity
Metal binding1341Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
A6GW45 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: 60B4918F1D7C8FD9

FASTA24628,383
        10         20         30         40         50         60 
MSFIKKIFLS SRSSEDGLFF SKLEKILGFK PLNLTHFRRA FTHRSMNKLD EKGNPMNYER 

        70         80         90        100        110        120 
LEFMGDAMLG SVIAAHLFNM SPTGDEGYLT KMRSKIVSRE HLNELGKDLN LIQFLESKVT 

       130        140        150        160        170        180 
LQNFGENIHG NLFEAFVGAI YLDRGFVYCE KFIHKKVIKP YVDIDKLEGK VISYKSLLIE 

       190        200        210        220        230        240 
WCQKEKRVFH YDIYEDEDAG KLKYFGVKLS IDGKVVAKAR ATSKKKAEEI ASKRGYFVFQ 


SEIDGK 

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References

[1]"Complete genome sequence of the fish pathogen Flavobacterium psychrophilum."
Duchaud E., Boussaha M., Loux V., Bernardet J.-F., Michel C., Kerouault B., Mondot S., Nicolas P., Bossy R., Caron C., Bessieres P., Gibrat J.-F., Claverol S., Dumetz F., Le Henaff M., Benmansour A.
Nat. Biotechnol. 25:763-769(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JIP02/86 / ATCC 49511.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM398681 Genomic DNA. Translation: CAL42318.1.
RefSeqYP_001295138.1. NC_009613.3.

3D structure databases

ProteinModelPortalA6GW45.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING402612.FP0202.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAL42318; CAL42318; FP0202.
GeneID5298888.
KEGGfps:FP0202.
PATRIC21905240. VBIFlaPsy4505_0211.

Phylogenomic databases

eggNOGCOG0571.
HOGENOMHOG000246808.
KOK03685.
OMANIHGNLF.
OrthoDBEOG6T1WVS.
ProtClustDBCLSK851875.

Enzyme and pathway databases

BioCycFPSY402612:GJEP-344-MONOMER.

Family and domain databases

Gene3D1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
HAMAPMF_00104. RNase_III.
InterProIPR014720. dsRNA-bd_dom.
IPR011907. RNase_III.
IPR000999. RNase_III_dom.
[Graphical view]
PANTHERPTHR11207. PTHR11207. 1 hit.
PfamPF00035. dsrm. 1 hit.
PF14622. Ribonucleas_3_3. 1 hit.
[Graphical view]
SMARTSM00358. DSRM. 1 hit.
SM00535. RIBOc. 1 hit.
[Graphical view]
SUPFAMSSF69065. SSF69065. 1 hit.
TIGRFAMsTIGR02191. RNaseIII. 1 hit.
PROSITEPS50137. DS_RBD. 1 hit.
PS50142. RNASE_3_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRNC_FLAPJ
AccessionPrimary (citable) accession number: A6GW45
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 24, 2007
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families