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A6CQT3 (A6CQT3_9BACI) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine--tRNA ligase HAMAP-Rule MF_00176
EC=6.1.1.11 HAMAP-Rule MF_00176
Alternative name(s):
Seryl-tRNA synthetase HAMAP-Rule MF_00176
Seryl-tRNA(Ser/Sec) synthetase HAMAP-Rule MF_00176
Gene names
Name:serS HAMAP-Rule MF_00176
ORF Names:BSG1_10723 EMBL EDL63797.1
OrganismBacillus sp. SG-1 EMBL EDL63797.1
Taxonomic identifier161544 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length426 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) By similarity. HAMAP-Rule MF_00176

Catalytic activity

ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec). HAMAP-Rule MF_00176

ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). HAMAP-Rule MF_00176

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1. HAMAP-Rule MF_00176

Subunit structure

Homodimer. The tRNA molecule binds across the dimer By similarity. HAMAP-Rule MF_00176

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00176.

Domain

Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding By similarity. HAMAP-Rule MF_00176

Sequence similarities

Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. HAMAP-Rule MF_00176

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding262 – 2643ATP By similarity HAMAP-Rule MF_00176
Nucleotide binding349 – 3524ATP By similarity HAMAP-Rule MF_00176
Region231 – 2333Serine binding By similarity HAMAP-Rule MF_00176

Sites

Binding site2851Serine By similarity HAMAP-Rule MF_00176
Binding site3851Serine By similarity HAMAP-Rule MF_00176

Sequences

Sequence LengthMass (Da)Tools
A6CQT3 [UniParc].

Last modified July 24, 2007. Version 1.
Checksum: C7F02FD1496D5038

FASTA42648,943
        10         20         30         40         50         60 
MLDIRHLRAN FEDVKNRLQD RGEDLSDFEK FEELDVRRRE LLVETENLKS KRNEVSQKIA 

        70         80         90        100        110        120 
EMKKNKENAD DLIVEMREVG GMIKKLDEEL KEVEGSLDHL MLSIPNIPHE SVPVGATEDD 

       130        140        150        160        170        180 
NVEARKWGEV PSFDFEPKPH WDLATELGVL DFERASKVTG SRFVFYKGLG ARLERALINF 

       190        200        210        220        230        240 
MMDLHMDEHG YEEMLPPYMV NRESMTGTGQ LPKFEEDAFL IESEDYFLVP TAEVPVTNYH 

       250        260        270        280        290        300 
RDEILTNDQL PIAYTAFSAC FRSEAGSAGR DTRGLIRQHQ FNKVELVRFV RPEESYDELE 

       310        320        330        340        350        360 
KLTGHAEKVL QLLNLPYRVM SMCTADLGFT AAKKYDIEVW IPSYGTYREI SSCSNFEAFQ 

       370        380        390        400        410        420 
ARRANIRFRR EPGCKPEHVH TLNGSGLALG RTVAAILENY QQADGSIVIP EVLRPYMRGV 


EVIKPK

« Hide

References

[1]Tebo B., Ferriera S., Johnson J., Kravitz S., Beeson K., Sutton G., Rogers Y.-H., Friedman R., Frazier M., Venter J.C.
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: SG-1 EMBL EDL63797.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		ABCF01000039 Genomic DNA. Translation: EDL63797.1.

3D structure databases

ProteinModelPortalA6CQT3.
SMRA6CQT3. Positions 1-426.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEDL63797; EDL63797; BSG1_10723.
PATRIC25232543. VBIBacSp59792_2887.

Enzyme and pathway databases

UniPathwayUPA00906; UER00895.

Family and domain databases

Gene3D1.10.287.40. 1 hit.
HAMAPMF_00176. Ser_tRNA_synth_type1.
InterProIPR002314. aa-tRNA-synt_IIb_cons-dom.
IPR006195. aa-tRNA-synth_II.
IPR002317. Ser-tRNA-ligase_type_1.
IPR015866. Ser-tRNA-synth_1_N.
IPR010978. tRNA-bd_arm.
[Graphical view]
PANTHERPTHR11778. PTHR11778. 1 hit.
PfamPF02403. Seryl_tRNA_N. 1 hit.
PF00587. tRNA-synt_2b. 1 hit.
[Graphical view]
PIRSFPIRSF001529. Ser-tRNA-synth_IIa. 1 hit.
PRINTSPR00981. TRNASYNTHSER.
SUPFAMSSF46589. tRNA_binding_arm. 1 hit.
TIGRFAMsTIGR00414. serS. 1 hit.
PROSITEPS50862. AA_TRNA_LIGASE_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA6CQT3_9BACI
AccessionPrimary (citable) accession number: A6CQT3
Entry history
Integrated into UniProtKB/TrEMBL: July 24, 2007
Last sequence update: July 24, 2007
Last modified: April 3, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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