Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Multiple epidermal growth factor-like domains protein 11

Gene

MEGF11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple epidermal growth factor-like domains protein 11
Short name:
Multiple EGF-like domains protein 11
Gene namesi
Name:MEGF11
Synonyms:KIAA1781
ORF Names:UNQ1949/PRO4432
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:29635. MEGF11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 848829ExtracellularSequence analysisAdd
BLAST
Transmembranei849 – 86921HelicalSequence analysisAdd
BLAST
Topological domaini870 – 1044175CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596411.

Polymorphism and mutation databases

BioMutaiMEGF11.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 10441025Multiple epidermal growth factor-like domains protein 11PRO_0000309735Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 89Sequence analysis
Disulfide bondi54 ↔ 63Sequence analysis
Disulfide bondi88 ↔ 99Sequence analysis
Disulfide bondi103 ↔ 118By similarity
Disulfide bondi120 ↔ 129By similarity
Disulfide bondi146 ↔ 154By similarity
Disulfide bondi148 ↔ 161By similarity
Disulfide bondi163 ↔ 172By similarity
Disulfide bondi185 ↔ 197By similarity
Disulfide bondi191 ↔ 204By similarity
Disulfide bondi206 ↔ 215By similarity
Disulfide bondi228 ↔ 240By similarity
Disulfide bondi234 ↔ 247By similarity
Disulfide bondi249 ↔ 258By similarity
Glycosylationi270 – 2701N-linked (GlcNAc...)Sequence analysis
Disulfide bondi271 ↔ 283By similarity
Disulfide bondi277 ↔ 290By similarity
Disulfide bondi292 ↔ 301By similarity
Disulfide bondi314 ↔ 326By similarity
Disulfide bondi320 ↔ 333By similarity
Disulfide bondi335 ↔ 344By similarity
Disulfide bondi403 ↔ 415By similarity
Disulfide bondi409 ↔ 422By similarity
Disulfide bondi424 ↔ 433By similarity
Disulfide bondi446 ↔ 458By similarity
Disulfide bondi452 ↔ 465By similarity
Disulfide bondi467 ↔ 476By similarity
Disulfide bondi493 ↔ 501By similarity
Disulfide bondi495 ↔ 508By similarity
Disulfide bondi510 ↔ 519By similarity
Glycosylationi531 – 5311N-linked (GlcNAc...)Sequence analysis
Disulfide bondi575 ↔ 587By similarity
Disulfide bondi581 ↔ 594By similarity
Disulfide bondi596 ↔ 605By similarity
Disulfide bondi663 ↔ 675By similarity
Disulfide bondi669 ↔ 682By similarity
Disulfide bondi684 ↔ 693By similarity
Disulfide bondi710 ↔ 718By similarity
Disulfide bondi712 ↔ 725By similarity
Disulfide bondi727 ↔ 736By similarity
Disulfide bondi753 ↔ 761By similarity
Disulfide bondi755 ↔ 768By similarity
Disulfide bondi770 ↔ 779By similarity
Disulfide bondi792 ↔ 804By similarity
Disulfide bondi798 ↔ 811By similarity
Disulfide bondi813 ↔ 822By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiA6BM72.
PeptideAtlasiA6BM72.
PRIDEiA6BM72.
TopDownProteomicsiA6BM72-3. [A6BM72-3]

PTM databases

iPTMnetiA6BM72.
PhosphoSiteiA6BM72.

Expressioni

Gene expression databases

BgeeiA6BM72.
CleanExiHS_MEGF11.
ExpressionAtlasiA6BM72. baseline and differential.
GenevisibleiA6BM72. HS.

Organism-specific databases

HPAiHPA017982.

Interactioni

Subunit structurei

Homopolymer (Probable). Does not interact with MEGF10.Curated

Protein-protein interaction databases

BioGridi124098. 2 interactions.
IntActiA6BM72. 1 interaction.
MINTiMINT-2877220.
STRINGi9606.ENSP00000386908.

Structurei

3D structure databases

ProteinModelPortaliA6BM72.
SMRiA6BM72. Positions 96-216, 219-827.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10178EMIPROSITE-ProRule annotationAdd
BLAST
Domaini95 – 13036EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini143 – 17331EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini181 – 21636EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini224 – 25936EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini267 – 30236EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini310 – 34536EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini399 – 43436EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini442 – 47736EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini490 – 52031EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini571 – 60636EGF-like 10PROSITE-ProRule annotationAdd
BLAST
Domaini659 – 69436EGF-like 11PROSITE-ProRule annotationAdd
BLAST
Domaini707 – 73731EGF-like 12PROSITE-ProRule annotationAdd
BLAST
Domaini750 – 78031EGF-like 13PROSITE-ProRule annotationAdd
BLAST
Domaini788 – 82336EGF-like 14PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MEGF family.Curated
Contains 14 EGF-like domains.PROSITE-ProRule annotation
Contains 1 EMI domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00730000110380.
HOGENOMiHOG000294130.
HOVERGENiHBG108333.
InParanoidiA6BM72.
PhylomeDBiA6BM72.
TreeFamiTF332598.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011489. EMI_domain.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF12661. hEGF. 3 hits.
PF00053. Laminin_EGF. 8 hits.
[Graphical view]
SMARTiSM00181. EGF. 17 hits.
SM00180. EGF_Lam. 16 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 17 hits.
PS01186. EGF_2. 17 hits.
PS50026. EGF_3. 14 hits.
PS51041. EMI. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A6BM72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLSLTGLIA FSFLQATLAL NPEDPNVCSH WESYAVTVQE SYAHPFDQIY
60 70 80 90 100
YTRCTDILNW FKCTRHRISY KTAYRRGLRT MYRRRSQCCP GYYESGDFCI
110 120 130 140 150
PLCTEECVHG RCVSPDTCHC EPGWGGPDCS SGCDSDHWGP HCSNRCQCQN
160 170 180 190 200
GALCNPITGA CVCAAGFRGW RCEELCAPGT HGKGCQLPCQ CRHGASCDPR
210 220 230 240 250
AGECLCAPGY TGVYCEELCP PGSHGAHCEL RCPCQNGGTC HHITGECACP
260 270 280 290 300
PGWTGAVCAQ PCPPGTFGQN CSQDCPCHHG GQCDHVTGQC HCTAGYMGDR
310 320 330 340 350
CQEECPFGSF GFQCSQHCDC HNGGQCSPTT GACECEPGYK GPRCQERLCP
360 370 380 390 400
EGLHGPGCTL PCPCDADNTI SCHPVTGACT CQPGWSGHHC NESCPVGYYG
410 420 430 440 450
DGCQLPCTCQ NGADCHSITG GCTCAPGFMG EVCAVSCAAG TYGPNCSSIC
460 470 480 490 500
SCNNGGTCSP VDGSCTCKEG WQGLDCTLPC PSGTWGLNCN ESCTCANGAA
510 520 530 540 550
CSPIDGSCSC TPGWLGDTCE LPCPDGTFGL NCSEHCDCSH ADGCDPVTGH
560 570 580 590 600
CCCLAGWTGI RCDSTCPPGR WGPNCSVSCS CENGGSCSPE DGSCECAPGF
610 620 630 640 650
RGPLCQRICP PGFYGHGCAQ PCPLCVHSSR PCHHISGICE CLPGFSGALC
660 670 680 690 700
NQVCAGGYFG QDCAQLCSCA NNGTCSPIDG SCQCFPGWIG KDCSQACPPG
710 720 730 740 750
FWGPACFHAC SCHNGASCSA EDGACHCTPG WTGLFCTQRC PAAFFGKDCG
760 770 780 790 800
RVCQCQNGAS CDHISGKCTC RTGFTGQHCE QRCAPGTFGY GCQQLCECMN
810 820 830 840 850
NSTCDHVTGT CYCSPGFKGI RCDQAALMME ELNPYTKISP ALGAERHSVG
860 870 880 890 900
AVTGIMLLLF LIVVLLGLFA WHRRRQKEKG RDLAPRVSYT PAMRMTSTDY
910 920 930 940 950
SLSGACGMDR RQNTYIMDKG FKDYMKESVC SSSTCSLNSS ENPYATIKDP
960 970 980 990 1000
PILTCKLPES SYVEMKSPVH MGSPYTDVPS LSTSNKNIYE VEPTVSVVQE
1010 1020 1030 1040
GCGHNSSYIQ NAYDLPRNSH IPGHYDLLPV RQSPANGPSQ DKQS
Length:1,044
Mass (Da):110,844
Last modified:March 24, 2009 - v3
Checksum:i8F4CF00B8B1DFCA2
GO
Isoform 2 (identifier: A6BM72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-75: Missing.
     76-101: RGLRTMYRRRSQCCPGYYESGDFCIP → MHTPSIRSITHDAQTSSTGSSAPGTA

Show »
Length:969
Mass (Da):101,548
Checksum:i33A607F53A94122C
GO
Isoform 3 (identifier: A6BM72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     740-875: CPAAFFGKDC...LGLFAWHRRR → KPHLLASQPL...AMGVSSYVSA
     876-1044: Missing.

Show »
Length:875
Mass (Da):91,433
Checksum:i3E0C7349059398BE
GO
Isoform 4 (identifier: A6BM72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-827: Missing.
     904-964: GACGMDRRQN...CKLPESSYVE → ASTTPWWPVM...GQVPARGLLH
     965-1044: Missing.

Show »
Length:137
Mass (Da):15,467
Checksum:i38E532CEC65E3CD5
GO

Sequence cautioni

The sequence BAB47410.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAD38994.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti95 – 951S → N.1 Publication
Corresponds to variant rs16949528 [ dbSNP | Ensembl ].
VAR_059261
Natural varianti242 – 2421H → R.
Corresponds to variant rs333550 [ dbSNP | Ensembl ].
VAR_036990
Natural varianti317 – 3171H → R.3 Publications
Corresponds to variant rs333550 [ dbSNP | Ensembl ].
VAR_059262
Natural varianti474 – 4741L → P.
Corresponds to variant rs35309197 [ dbSNP | Ensembl ].
VAR_059263
Natural varianti861 – 8611L → F.1 Publication
Corresponds to variant rs3803414 [ dbSNP | Ensembl ].
VAR_059264
Natural varianti988 – 9881I → T.
Corresponds to variant rs2303374 [ dbSNP | Ensembl ].
VAR_059265

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 827827Missing in isoform 4. 1 PublicationVSP_029246Add
BLAST
Alternative sequencei1 – 7575Missing in isoform 2. 1 PublicationVSP_029247Add
BLAST
Alternative sequencei76 – 10126RGLRT…DFCIP → MHTPSIRSITHDAQTSSTGS SAPGTA in isoform 2. 1 PublicationVSP_029248Add
BLAST
Alternative sequencei740 – 875136CPAAF…WHRRR → KPHLLASQPLRIPCCGLLAT VGIVQTSREGGMQAAPGLVV PDSCPTRTEELCRGSSRPDW IQGIDKPKVLEGQGCKAAQQ HFLGRTVGAYASVRMAPAVT TSVASAPAAQASPGNTVSRD VPQEPLAMGVSSYVSA in isoform 3. 1 PublicationVSP_029249Add
BLAST
Alternative sequencei876 – 1044169Missing in isoform 3. 1 PublicationVSP_029250Add
BLAST
Alternative sequencei904 – 96461GACGM…SSYVE → ASTTPWWPVMEHLARPFSQR PRTQLSNKSLDRDTAGWTPY SYVNVLDQCPGGQVPARGLL H in isoform 4. 1 PublicationVSP_029251Add
BLAST
Alternative sequencei965 – 104480Missing in isoform 4. 1 PublicationVSP_029252Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058677 mRNA. Translation: BAB47410.2. Different initiation.
AB300051 mRNA. Translation: BAF64841.1.
AY358226 mRNA. Translation: AAQ88593.1.
AC011847 Genomic DNA. No translation available.
AC084854 Genomic DNA. No translation available.
AC087382 Genomic DNA. No translation available.
BC117419 mRNA. Translation: AAI17420.1.
BC126313 mRNA. Translation: AAI26314.1.
AL834326 mRNA. Translation: CAD38994.1. Different initiation.
CCDSiCCDS10213.2. [A6BM72-1]
RefSeqiNP_115821.2. NM_032445.2. [A6BM72-1]
UniGeneiHs.712886.

Genome annotation databases

EnsembliENST00000288745; ENSP00000288745; ENSG00000157890. [A6BM72-2]
ENST00000409699; ENSP00000386908; ENSG00000157890. [A6BM72-1]
ENST00000422354; ENSP00000414475; ENSG00000157890. [A6BM72-1]
GeneIDi84465.
KEGGihsa:84465.
UCSCiuc002apl.2. human. [A6BM72-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB058677 mRNA. Translation: BAB47410.2. Different initiation.
AB300051 mRNA. Translation: BAF64841.1.
AY358226 mRNA. Translation: AAQ88593.1.
AC011847 Genomic DNA. No translation available.
AC084854 Genomic DNA. No translation available.
AC087382 Genomic DNA. No translation available.
BC117419 mRNA. Translation: AAI17420.1.
BC126313 mRNA. Translation: AAI26314.1.
AL834326 mRNA. Translation: CAD38994.1. Different initiation.
CCDSiCCDS10213.2. [A6BM72-1]
RefSeqiNP_115821.2. NM_032445.2. [A6BM72-1]
UniGeneiHs.712886.

3D structure databases

ProteinModelPortaliA6BM72.
SMRiA6BM72. Positions 96-216, 219-827.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124098. 2 interactions.
IntActiA6BM72. 1 interaction.
MINTiMINT-2877220.
STRINGi9606.ENSP00000386908.

PTM databases

iPTMnetiA6BM72.
PhosphoSiteiA6BM72.

Polymorphism and mutation databases

BioMutaiMEGF11.

Proteomic databases

PaxDbiA6BM72.
PeptideAtlasiA6BM72.
PRIDEiA6BM72.
TopDownProteomicsiA6BM72-3. [A6BM72-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288745; ENSP00000288745; ENSG00000157890. [A6BM72-2]
ENST00000409699; ENSP00000386908; ENSG00000157890. [A6BM72-1]
ENST00000422354; ENSP00000414475; ENSG00000157890. [A6BM72-1]
GeneIDi84465.
KEGGihsa:84465.
UCSCiuc002apl.2. human. [A6BM72-1]

Organism-specific databases

CTDi84465.
GeneCardsiMEGF11.
H-InvDBHIX0018384.
HGNCiHGNC:29635. MEGF11.
HPAiHPA017982.
MIMi612454. gene.
neXtProtiNX_A6BM72.
PharmGKBiPA144596411.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1218. Eukaryota.
ENOG410XQWV. LUCA.
GeneTreeiENSGT00730000110380.
HOGENOMiHOG000294130.
HOVERGENiHBG108333.
InParanoidiA6BM72.
PhylomeDBiA6BM72.
TreeFamiTF332598.

Miscellaneous databases

ChiTaRSiMEGF11. human.
GenomeRNAii84465.
PROiA6BM72.
SOURCEiSearch...

Gene expression databases

BgeeiA6BM72.
CleanExiHS_MEGF11.
ExpressionAtlasiA6BM72. baseline and differential.
GenevisibleiA6BM72. HS.

Family and domain databases

InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR011489. EMI_domain.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF12661. hEGF. 3 hits.
PF00053. Laminin_EGF. 8 hits.
[Graphical view]
SMARTiSM00181. EGF. 17 hits.
SM00180. EGF_Lam. 16 hits.
[Graphical view]
PROSITEiPS00022. EGF_1. 17 hits.
PS01186. EGF_2. 17 hits.
PS50026. EGF_3. 14 hits.
PS51041. EMI. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.
    DNA Res. 8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANTS ARG-317 AND PHE-861.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  3. "Analysis of the DNA sequence and duplication history of human chromosome 15."
    Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A.
    , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.
    Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS ASN-95 AND ARG-317.
    Tissue: Brain.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 255-1044 (ISOFORM 3), VARIANT ARG-317.
    Tissue: Testis.
  6. "The mammalian Ced-1 ortholog MEGF10/KIAA1780 displays a novel adhesion pattern."
    Suzuki E., Nakayama M.
    Exp. Cell Res. 313:2451-2464(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
    Tissue: Brain.

Entry informationi

Entry nameiMEG11_HUMAN
AccessioniPrimary (citable) accession number: A6BM72
Secondary accession number(s): Q17R86
, Q6UXS5, Q8ND91, Q96KG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: March 24, 2009
Last modified: July 6, 2016
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.