A6AYZ6 (A6AYZ6_VIBPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1 HAMAP MF_00108
EC=2.7.7.60 HAMAP MF_00108

Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase 1 HAMAP MF_00108
MEP cytidylyltransferase 1 HAMAP MF_00108

Gene names

Name:	ispD1 HAMAP MF_00108
ORF Names:	A79_6227 EMBL EDM60926.1

Organism

Vibrio parahaemolyticus AQ3810 EMBL EDM60926.1

Taxonomic identifier

419109 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU003490
Catalytic activity	CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU003490
Pathway	Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 SAAS SAAS018294 RuleBase RU004138
Sequence similarities	Belongs to the IspD family. HAMAP MF_00108 RuleBase RU004393

Ontologies

Keywords
Biological process	Isoprene biosynthesis HAMAP MF_00108 SAAS SAAS018294 RuleBase RU004393
Molecular function	Nucleotidyltransferase HAMAP MF_00108 SAAS SAAS018294 RuleBase RU004393 Transferase
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Site	14	1	Transition state stabilizer By similarity HAMAP MF_00108
	Site	22	1	Transition state stabilizer By similarity HAMAP MF_00108
	Site	157	1	Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
	Site	214	1	Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

	Sequence		Length	Mass (Da)
	A6AYZ6 [UniParc]. Last modified July 24, 2007. Version 1. Checksum: 3BEEB98734370510	FASTA	238	27,076
	10 20 30 40 50 60 MNVALIFAGG VGTRMQNSTK PKQFLELYNK PVIIYTLEKF EENKNIDAIV VVCVEPWIDY 70 80 90 100 110 120 LRKLLFKFDI QKVKFVIPGG ETGQESIFNG LCKIEEEFDH NSVVLIHDGV RPLINDEIIN 130 140 150 160 170 180 RNIEAVKSHG SAITTCPPVE TFVLVDNEDV VKDVHDRSLS RLAKAPQSFY LRDILKVHRQ 190 200 210 220 230 AREDCYTEAI DSCSLMTKYG YDVRLVSGIS ENIKITSPID FFIFKAIIDT QENLQVFG

References

[1]	"Annotation of Vibrio parahaemolyticus AQ3810." Heidelberg J., Sebastian Y. Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: AQ3810 EMBL EDM60926.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAWQ01000004 Genomic DNA. Translation: EDM60926.1.
3D structure databases
ProteinModelPortal	A6AYZ6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	38611756. VBIVibPar22798_0546.
Phylogenomic databases
OMA	VDETITR.
Family and domain databases
HAMAP	MF_00108. IspD. [Tree]
InterPro	IPR001228. ISPD_synthase. IPR018294. ISPD_synthase_CS. [Graphical view]
Pfam	PF01128. IspD. 1 hit. [Graphical view]
PROSITE	PS01295. ISPD. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A6AYZ6_VIBPA

Accession

Primary (citable) accession number: A6AYZ6

Entry history

Integrated into UniProtKB/TrEMBL:	July 24, 2007
Last sequence update:	July 24, 2007
Last modified:	December 14, 2011
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)