ID A5ZY13_9FIRM Unreviewed; 663 AA. AC A5ZY13; DT 24-JUL-2007, integrated into UniProtKB/TrEMBL. DT 24-JUL-2007, sequence version 1. DT 27-MAR-2024, entry version 75. DE SubName: Full=Glycosyl hydrolase, family 31 {ECO:0000313|EMBL:EDM85535.1}; DE EC=3.2.1.- {ECO:0000313|EMBL:EDM85535.1}; GN ORFNames=RUMOBE_03919 {ECO:0000313|EMBL:EDM85535.1}; OS Blautia obeum ATCC 29174. OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae; Blautia. OX NCBI_TaxID=411459 {ECO:0000313|EMBL:EDM85535.1, ECO:0000313|Proteomes:UP000006002}; RN [1] {ECO:0000313|EMBL:EDM85535.1, ECO:0000313|Proteomes:UP000006002} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 29174 {ECO:0000313|EMBL:EDM85535.1, RC ECO:0000313|Proteomes:UP000006002}; RA Mo X., Chen Z., Chen J.; RL Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:EDM85535.1, ECO:0000313|Proteomes:UP000006002} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 29174 {ECO:0000313|EMBL:EDM85535.1, RC ECO:0000313|Proteomes:UP000006002}; RA Sudarsanam P., Ley R., Guruge J., Turnbaugh P.J., Mahowald M., Liep D., RA Gordon J.; RT "Draft genome sequence of Ruminococcus obeum (ATCC 29174)."; RL Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0007829|PDB:3M46, ECO:0007829|PDB:3M6D} RP X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) IN COMPLEX WITH GLUCOSE. RX PubMed=20581222; DOI=10.1096/fj.10-156257; RA Tan K., Tesar C., Wilton R., Keigher L., Babnigg G., Joachimiak A.; RT "Novel alpha-glucosidase from human gut microbiome: substrate specificities RT and their switch."; RL FASEB J. 24:3939-3949(2010). RN [4] {ECO:0007829|PDB:3NSX} RP X-RAY CRYSTALLOGRAPHY (1.57 ANGSTROMS). RA Tan K., Tesar C., Wilton R., Keigher L., Babnigg G., Joachimiak A.; RT "The crystal structure of the The crystal structure of the D420A mutant of RT the alpha-glucosidase (FAMILY 31) from Ruminococcus obeum ATCC 29174."; RL Submitted (JUL-2010) to the PDB data bank. RN [5] {ECO:0007829|PDB:3NUK} RP X-RAY CRYSTALLOGRAPHY (2.06 ANGSTROMS). RA Tan K., Tesar C., Wilton R., Keigher L., Babnigg G., Joachimiak A.; RT "THE CRYSTAL STRUCTURE OF THE W169Y mutant of ALPHA-GLUCOSIDASE (FAMILY 31) RT from RUMINOCOCCUS OBEUM ATCC 29174."; RL Submitted (JUL-2010) to the PDB data bank. RN [6] {ECO:0007829|PDB:3POC} RP X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS). RA Tan K., Tesar C., Wilton R., Keigher L., Babnigg G., Joachimiak A.; RT "The crystal structure of the D307A mutant of alpha-Glucosidase (FAMILY 31) RT from Ruminococcus obeum ATCC 29174 in complex with acarbose."; RL Submitted (NOV-2010) to the PDB data bank. RN [7] {ECO:0007829|PDB:3PHA} RP X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS). RA Tan K., Tesar C., Keigher L., Babnigg G., Joachimiak A.; RT "The crystal structure of the W169Y mutant of alpha-glucosidase (gh31 RT family) from Ruminococcus obeum atcc 29174 in complex with acarbose."; RL Submitted (NOV-2010) to the PDB data bank. RN [8] {ECO:0007829|PDB:6C9X} RP X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS). RA Tan K., Tesar C., Jedrzejczak R., Joachimiak A.; RT "THE CRYSTAL STRUCTURE OF THE alpha-Glucosidase (GH 31) FROM RUMINOCOCCUS RT OBEUM ATCC 29174 in complex with voglibose."; RL Submitted (JAN-2018) to the PDB data bank. RN [9] {ECO:0007829|PDB:6C9Z} RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS). RA Tan K., Tesar C., Jedrzejczak R., Joachimiak A.; RT "THE CRYSTAL STRUCTURE OF THE alpha-Glucosidase (GH 31) W169Y mutant FROM RT RUMINOCOCCUS OBEUM ATCC 29174 in complex with voglibose."; RL Submitted (JAN-2018) to the PDB data bank. RN [10] {ECO:0007829|PDB:6CA1, ECO:0007829|PDB:6CA3} RP X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS). RA Tan K., Tesar C., Jedrzejczak R., Joachimiak A.; RT "THE CRYSTAL STRUCTURE OF THE W169Y MUTANT OF ALPHA-GLUCOSIDASE (GH 31) RT FROM RUMINOCOCCUS OBEUM ATCC 29174 in complex with miglitol."; RL Submitted (JAN-2018) to the PDB data bank. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 31 family. CC {ECO:0000256|ARBA:ARBA00007806, ECO:0000256|RuleBase:RU361185}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:EDM85535.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAVO02000029; EDM85535.1; -; Genomic_DNA. DR RefSeq; WP_005425354.1; NZ_DS264318.1. DR PDB; 3M46; X-ray; 2.66 A; A/B=1-663. DR PDB; 3M6D; X-ray; 2.90 A; A/B=1-663. DR PDB; 3MKK; X-ray; 1.91 A; A/B=1-663. DR PDB; 3N04; X-ray; 2.02 A; A/B=1-663. DR PDB; 3NSX; X-ray; 1.57 A; A/B=1-663. DR PDB; 3NUK; X-ray; 2.06 A; A/B=1-663. DR PDB; 3PHA; X-ray; 2.17 A; A/B/C/D=1-663. DR PDB; 3POC; X-ray; 1.99 A; A/B=1-663. DR PDB; 6C9X; X-ray; 1.46 A; A/B=1-663. DR PDB; 6C9Z; X-ray; 2.10 A; A/B=1-663. DR PDB; 6CA1; X-ray; 1.95 A; A/B=1-663. DR PDB; 6CA3; X-ray; 1.74 A; A/B=1-663. DR PDBsum; 3M46; -. DR PDBsum; 3M6D; -. DR PDBsum; 3MKK; -. DR PDBsum; 3N04; -. DR PDBsum; 3NSX; -. DR PDBsum; 3NUK; -. DR PDBsum; 3PHA; -. DR PDBsum; 3POC; -. DR PDBsum; 6C9X; -. DR PDBsum; 6C9Z; -. DR PDBsum; 6CA1; -. DR PDBsum; 6CA3; -. DR AlphaFoldDB; A5ZY13; -. DR SMR; A5ZY13; -. DR CAZy; GH31; Glycoside Hydrolase Family 31. DR GeneID; 79804970; -. DR eggNOG; COG1501; Bacteria. DR HOGENOM; CLU_000631_7_2_9; -. DR EvolutionaryTrace; A5ZY13; -. DR Proteomes; UP000006002; Unassembled WGS sequence. DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro. DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro. DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. DR CDD; cd06604; GH31_glucosidase_II_MalA; 1. DR CDD; cd14752; GH31_N; 1. DR Gene3D; 2.60.40.4040; -; 1. DR Gene3D; 3.20.20.80; Glycosidases; 1. DR Gene3D; 2.60.40.1760; glycosyl hydrolase (family 31); 1. DR InterPro; IPR011013; Gal_mutarotase_sf_dom. DR InterPro; IPR030458; Glyco_hydro_31_AS. DR InterPro; IPR048395; Glyco_hydro_31_C. DR InterPro; IPR025887; Glyco_hydro_31_N_dom. DR InterPro; IPR000322; Glyco_hydro_31_TIM. DR InterPro; IPR017853; Glycoside_hydrolase_SF. DR PANTHER; PTHR22762; ALPHA-GLUCOSIDASE; 1. DR PANTHER; PTHR22762:SF166; ALPHA-GLUCOSIDASE; 1. DR Pfam; PF13802; Gal_mutarotas_2; 1. DR Pfam; PF01055; Glyco_hydro_31_2nd; 1. DR Pfam; PF21365; Glyco_hydro_31_3rd; 1. DR SUPFAM; SSF51445; (Trans)glycosidases; 1. DR SUPFAM; SSF74650; Galactose mutarotase-like; 1. DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1. DR PROSITE; PS00129; GLYCOSYL_HYDROL_F31_1; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:3M46, ECO:0007829|PDB:3M6D}; KW Glycosidase {ECO:0000256|RuleBase:RU361185, ECO:0000313|EMBL:EDM85535.1}; KW Hydrolase {ECO:0000256|RuleBase:RU361185, ECO:0000313|EMBL:EDM85535.1}. FT DOMAIN 27..112 FT /note="Glycoside hydrolase family 31 N-terminal" FT /evidence="ECO:0000259|Pfam:PF13802" FT DOMAIN 155..513 FT /note="Glycoside hydrolase family 31 TIM barrel" FT /evidence="ECO:0000259|Pfam:PF01055" FT DOMAIN 524..613 FT /note="Glycosyl hydrolase family 31 C-terminal" FT /evidence="ECO:0000259|Pfam:PF21365" FT CARBOHYD 197 FT /note="Glucose" FT /evidence="ECO:0007829|PDB:3MKK" FT CARBOHYD 404 FT /note="Glucose" FT /evidence="ECO:0007829|PDB:3MKK" FT CARBOHYD 420 FT /note="Glucose" FT /evidence="ECO:0007829|PDB:3MKK" FT CARBOHYD 478 FT /note="Glucose" FT /evidence="ECO:0007829|PDB:3MKK" SQ SEQUENCE 663 AA; 77083 MW; 8FAA32F7735D97E8 CRC64; MIRKYRYGAP FDTEALTEKI ETAEEAFPYG EISQKEGFAF TYIMDEDDIV YGLGESNRGI NKRGYCYISN CTDDPIHTED KRSLYGAHNF IIVSGKTTFG LFFDYPSKLT FDIGYTRMDT LKVSCENADL DIYVIEGENA YDIVKQFRRV IGRSYIPPKF AFGFGQSRWG YTTKEDFRAV AKGYRENHIP IDMIYMDIDY MQDFKDFTVN EKNFPDFPEF VKEMKDQELR LIPIIDAGVK VEKGYEVYEE GVKNNYFCKR EDGSDFVAAV WPGDTHFPDM LNPEARKWFG DKYRFLIDQG IEGFWNDMNE PAIFYSSEGL AEAKEFAGEF AKDTEGKIHP WAMQAKMKDI VNSPEDYKRF YHNVNGKKIR HDKVHNLFGY NMTRAAGEAF ERIDPEKRFL MFSRSSYIGM HRYGGIWMGD NKSWWSHILL NLKMLPSLNM CGFMYTGADL GGFGDDTTRD LLLRFLALGV FTPLMRDHAA EGTREQECYQ FENIEDFRSV INARYRLVPY LYSEYMKAAL NDDMYFKPLG FVYPDDKMAI RVEDQLMLGN EIMIAPVYEQ NARGRYVYLP EEMKFIKFMP DGSISEEVLE KGVHYVDVAL NEVPLFIRSG KCIPVAEAAE CVKDIDTENM QLIGYEGSSY TLYEDDGIHK DYDKKENYRV LTK //