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A5YV76

- A5YV76_PIG

UniProt

A5YV76 - A5YV76_PIG

Protein
Submitted name:

Fatty acid synthase

Gene

FASN

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1700 – 17001NADP; via amide nitrogenImported
    Binding sitei1704 – 17041NADPImported
    Binding sitei1769 – 17691NADP; via carbonyl oxygenImported
    Binding sitei1848 – 18481NADPImported
    Binding sitei1896 – 18961NADP; via amide nitrogenImported
    Binding sitei1945 – 19451NADPImported
    Binding sitei1971 – 19711NADP; via carbonyl oxygenImported
    Binding sitei1995 – 19951NADPImported
    Binding sitei2019 – 20191NADP; via carbonyl oxygenImported
    Binding sitei2063 – 20631NADP; via amide nitrogenImported
    Binding sitei2068 – 20681NADP; via amide nitrogenImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi1677 – 16804NADPImported
    Nucleotide bindingi1723 – 17242NADPImported
    Nucleotide bindingi1794 – 17963NADPImported
    Nucleotide bindingi1916 – 19216NADPImported

    GO - Molecular functioni

    1. [acyl-carrier-protein] S-acetyltransferase activity Source: InterPro
    2. [acyl-carrier-protein] S-malonyltransferase activity Source: InterPro
    3. 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Source: InterPro
    4. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: InterPro
    5. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
    6. enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Source: InterPro
    7. myristoyl-[acyl-carrier-protein] hydrolase activity Source: InterPro
    8. nucleotide binding Source: UniProtKB-KW
    9. oleoyl-[acyl-carrier-protein] hydrolase activity Source: InterPro
    10. palmitoyl-[acyl-carrier-protein] hydrolase activity Source: InterPro
    11. zinc ion binding Source: InterPro

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Keywords - Ligandi

    NADPImported, Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Fatty acid synthaseImported
    Gene namesi
    Name:FASNImported
    OrganismiSus scrofa (Pig)Imported
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

    PTM / Processingi

    Keywords - PTMi

    PhosphopantetheineUniRule annotation

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2VZ8X-ray3.22A/B1-2512[»]
    2VZ9X-ray3.30A/B1-2512[»]
    ProteinModelPortaliA5YV76.
    SMRiA5YV76. Positions 422-822, 2121-2206, 2222-2508.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiA5YV76.

    Family & Domainsi

    Sequence similaritiesi

    Contains acyl carrier domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG005640.
    KOiK00665.

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    1.10.1470.20. 1 hit.
    3.40.366.10. 2 hits.
    3.40.47.10. 2 hits.
    3.40.50.150. 1 hit.
    3.40.50.1820. 2 hits.
    3.40.50.720. 2 hits.
    InterProiIPR029058. AB_hydrolase.
    IPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR013149. ADH_C.
    IPR023102. Fatty_acid_synthase_dom_2.
    IPR011032. GroES-like.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR013217. Methyltransf_12.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020843. PKS_ER.
    IPR013968. PKS_KR.
    IPR006162. PPantetheine_attach_site.
    IPR029063. SAM-dependent_MTases-like.
    IPR001031. Thioesterase.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00698. Acyl_transf_1. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    PF08659. KR. 1 hit.
    PF08242. Methyltransf_12. 1 hit.
    PF00550. PP-binding. 1 hit.
    PF00975. Thioesterase. 1 hit.
    [Graphical view]
    SMARTiSM00829. PKS_ER. 1 hit.
    SM00822. PKS_KR. 1 hit.
    [Graphical view]
    SUPFAMiSSF47336. SSF47336. 1 hit.
    SSF50129. SSF50129. 1 hit.
    SSF52151. SSF52151. 2 hits.
    SSF53335. SSF53335. 1 hit.
    SSF53474. SSF53474. 1 hit.
    SSF53901. SSF53901. 2 hits.
    SSF55048. SSF55048. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5YV76-1 [UniParc]FASTAAdd to Basket

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    MEEVVIAGMS GKLPESENLE EFWANLIGGV DMVTADDRRW KAGLYGLPRR     50
    MGKLKDLSRF DASFFGVHSK QANTMDPQLR MLLEVTYEAI VDGGINPASL 100
    RGTSTGVWVG VSSSDASEAL SRDPETLVGY SMIGCQRAMM ANRLSFFFDF 150
    KGPSITIDTA CSSSLLALQS AYQAIRGGEC SAAVVGGLNV LLKPNSSLQF 200
    MKLGMLSQDG TCRSFDAEGT GYCRAEAVVA VLLTKKSLAR RVYATILNAG 250
    TNTDGSKEQG VTFPSGDVQE QLIRSLYAPA GPDPESLEYI EAHGTGTKVG 300
    DPQELNGIVN ALCATRREPL LIGSTKSNMG HPEPASGVAA LIKVLLSLEH 350
    GVWAPNLHYH TPNPEIPALQ DGRLQVVDRP LPIRGGNVGI NSFGFGGSNV 400
    HVILQPNSRP APPPAQHAAL PRLLQASGRT LEAVQTLLEQ GLRHSRDLAF 450
    VGMLNEIAAV SPVAMPFRGY AVLGGEAGSQ EVQQVPGSKR PVWFICSGMG 500
    AQWQGMGLSL MRLDRFRDSI LRSDQALKPL GLRVSDLLLS TDEAVLDDIV 550
    SSFVSLTSIQ IALIDLLTSL GLQPDGIIGH SLGEVACGYA DGCLTQEEAV 600
    LSSYWRGYCI KEANVLPGAM AAVGLSWEEC KQRCPPGIVP ACHNSKDTVT 650
    ISGPQAAMSE FLQQLKREDV FVKEVRTGGI AFHSYFMESI APTLLRQLRK 700
    VILDPKPRSK RWLSTSIPEA QWQGSLARTF SAEYSVNNLV SPVLFQEALQ 750
    HVPAHAVVVE IAPHALLQAV LKRSLESSCT IIPLMKKDHR DNLEFFLSNV 800
    GRLHLAGVSV NPNGLFPPVE FPAPRGTPLI SPHXKWDHSQ AWDVPSAADF 850
    PSGSSCSSVA VYKFDVSPES PDHYLVDHCI DGRVLFPGTG YLWLTWKTLA 900
    RALSQNLEET PVVFEDVTLH QATILPKTGT VSLEVRLLEA SHAFEVSDSN 950
    GSLIASGKVY QWESPDPKLF DTRAAVDPAD STAEFRLSQG DVYKDLRLRG 1000
    YDYGPFFQLV LESDLEGNRG RLQWNDSWVS FLDAMLHMSI LAPGQLGLYL 1050
    PTRFTSIRID PVTHRQKLYT LQDTTQAADV VVDRNLNTVV AGGALFLGAH 1100
    SSVAPRRPQE HLKPILEKFC FTPHVESGCL AGNTALQEEL QLCRGLAQAL 1150
    QTKVAQQGLK MVVPGLDGAQ APREAPQQSL PRLLAAACQL QLNGNLQLEL 1200
    GQVLAQERPL LCDDPLLSGL LDAPALKACV DTALENMASP KMKVVEVLAG 1250
    DGQLYSRIPA LLNTQPVMDL DYTATDRNPQ ALEAAQAKLE QLHVTQGQWD 1300
    PANPAPGSLG KADLLVCNCA LATLGDPAVA VGNMAATLKE GGFLLLHTLL 1350
    AGHPLGEMVG FLTSPEQGGR HLLSQDQWES LFAGASLHLV ALKRSFYGSV 1400
    LFLCRQQTPQ DSPVFLSVED TSFRWVDSLK DILADASSRP VWLMAVGCST 1450
    SGVVGMVNCL RKEPGGHRIR CVLVSNLSST SPAPEMHPSS SELQKVLQGD 1500
    LVMNVYRDGA WGAFRHFPLE QDRPEKQTEH AFVNVLSRGD LSSIRWVCSP 1550
    LHYALPASCQ DRLCSVYYTS LNFRDVMLAT GKLSPDSIPG KWLTRDCMLG 1600
    MEFSGRDASG RRVMGMVPAE GLATSVLLLQ HATWEVPSTW TLEEAASVPI 1650
    VYTTAYYSLV VRGRMQPGES VLIHSGSGGV GQAAIAIALS RGCRVFTTVG 1700
    SAEKRAYLQA RFPQLDETCF ANSRDTSFEQ HVLRHTAGKG VDLVLNSLAE 1750
    EKLQASVRCL AQHGRFLEIG KFDLSNNHAL GMAVFLKNVT FHGILLDSLF 1800
    EEGGATWQEV SELLKAGIQE GVVQPLKCTV FPRTKVEAAF RYMAQGKHIG 1850
    KVVIQVREEE QGPAPRGLPP IALTGLSKTF CPPHKSYVIT GGLGGFGLQL 1900
    AQWLRLRGAQ KLVLTSRSGI RTGYQARQVR EWRRQGVQVL VSTSNASSLD 1950
    GARSLITEAT QLGPVGGVFN LAMVLRDAVL ENQTPEFFQD VSKPKYSGTA 2000
    NLDRVTREAC PELDYFVIFS SVSCGRGNAG QANYGFANSA MERICEKRRH 2050
    DGLPGLAVQW GAIGDVGVVL ETMGTNDTVI GGTLPQRIAS CLEVLDLFLS 2100
    QPHPVLSSFV LAEKKAAAPR DGSSQKDLVK AVAHILGIRD VASINPDSTL 2150
    VDLGLDSLMG VEVRQILERE HDLVLSMREV RQLSLRKLQE LSSKTSTDAD 2200
    PATPTSHEDS PVRQQATLNL STLLVNPEGP TLTRLNSVQS AERPLFLVHP 2250
    IEGSITVFHG LAAKLSIPTY GLQCTGAAPL DSIQSLASYY IECIRQVQPE 2300
    GPYRIAGYSY GACVAFEMCS QLQAQQSATP GNHSLFLFDG SHTFVLAYTQ 2350
    SVRAKMTPGC EAEAEAKAMY FFVQQFTDME QGKVLEALIP LQGLEARVAA 2400
    TVDLITQSHA GLDRHALSFA ARSFYQKLRA AENYWPQATY HGNVTLLRAK 2450
    TGGAYGEDLG ADYNLSQVCD GKVSVHVIEG DHRTLLEGSG LESILSIIHS 2500
    CLAEPRVSVR EG 2512
    Length:2,512
    Mass (Da):272,250
    Last modified:July 10, 2007 - v1
    Checksum:iF57ABBAAC73E4B19
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF589048 mRNA. Translation: ABR09275.1.
    RefSeqiNP_001093400.1. NM_001099930.1.
    UniGeneiSsc.18175.

    Genome annotation databases

    GeneIDi397561.
    KEGGissc:397561.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF589048 mRNA. Translation: ABR09275.1 .
    RefSeqi NP_001093400.1. NM_001099930.1.
    UniGenei Ssc.18175.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2VZ8 X-ray 3.22 A/B 1-2512 [» ]
    2VZ9 X-ray 3.30 A/B 1-2512 [» ]
    ProteinModelPortali A5YV76.
    SMRi A5YV76. Positions 422-822, 2121-2206, 2222-2508.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 397561.
    KEGGi ssc:397561.

    Organism-specific databases

    CTDi 2194.

    Phylogenomic databases

    HOVERGENi HBG005640.
    KOi K00665.

    Miscellaneous databases

    EvolutionaryTracei A5YV76.

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    1.10.1470.20. 1 hit.
    3.40.366.10. 2 hits.
    3.40.47.10. 2 hits.
    3.40.50.150. 1 hit.
    3.40.50.1820. 2 hits.
    3.40.50.720. 2 hits.
    InterProi IPR029058. AB_hydrolase.
    IPR001227. Ac_transferase_dom.
    IPR009081. Acyl_carrier_prot-like.
    IPR014043. Acyl_transferase.
    IPR016035. Acyl_Trfase/lysoPLipase.
    IPR013149. ADH_C.
    IPR023102. Fatty_acid_synthase_dom_2.
    IPR011032. GroES-like.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016036. Malonyl_transacylase_ACP-bd.
    IPR013217. Methyltransf_12.
    IPR016040. NAD(P)-bd_dom.
    IPR020842. PKS/FAS_KR.
    IPR020843. PKS_ER.
    IPR013968. PKS_KR.
    IPR006162. PPantetheine_attach_site.
    IPR029063. SAM-dependent_MTases-like.
    IPR001031. Thioesterase.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00698. Acyl_transf_1. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    PF08659. KR. 1 hit.
    PF08242. Methyltransf_12. 1 hit.
    PF00550. PP-binding. 1 hit.
    PF00975. Thioesterase. 1 hit.
    [Graphical view ]
    SMARTi SM00829. PKS_ER. 1 hit.
    SM00822. PKS_KR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47336. SSF47336. 1 hit.
    SSF50129. SSF50129. 1 hit.
    SSF52151. SSF52151. 2 hits.
    SSF53335. SSF53335. 1 hit.
    SSF53474. SSF53474. 1 hit.
    SSF53901. SSF53901. 2 hits.
    SSF55048. SSF55048. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Gao L., Chen Z.
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The crystal structure of a mammalian fatty acid synthase."
      Maier T., Leibundgut M., Ban N.
      Science 321:1315-1322(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.22 ANGSTROMS) IN COMPLEX WITH NADP.

    Entry informationi

    Entry nameiA5YV76_PIG
    AccessioniPrimary (citable) accession number: A5YV76
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3