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A5YV76

- A5YV76_PIG

UniProt

A5YV76 - A5YV76_PIG

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Protein
Submitted name:

Fatty acid synthase

Gene

FASN

Organism
Sus scrofa (Pig)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1700 – 17001NADP; via amide nitrogenImported
Binding sitei1704 – 17041NADPImported
Binding sitei1769 – 17691NADP; via carbonyl oxygenImported
Binding sitei1848 – 18481NADPImported
Binding sitei1896 – 18961NADP; via amide nitrogenImported
Binding sitei1945 – 19451NADPImported
Binding sitei1971 – 19711NADP; via carbonyl oxygenImported
Binding sitei1995 – 19951NADPImported
Binding sitei2019 – 20191NADP; via carbonyl oxygenImported
Binding sitei2063 – 20631NADP; via amide nitrogenImported
Binding sitei2068 – 20681NADP; via amide nitrogenImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1677 – 16804NADPImported
Nucleotide bindingi1723 – 17242NADPImported
Nucleotide bindingi1794 – 17963NADPImported
Nucleotide bindingi1916 – 19216NADPImported

GO - Molecular functioni

  1. [acyl-carrier-protein] S-acetyltransferase activity Source: InterPro
  2. [acyl-carrier-protein] S-malonyltransferase activity Source: InterPro
  3. 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity Source: InterPro
  4. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: InterPro
  5. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
  6. enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity Source: InterPro
  7. myristoyl-[acyl-carrier-protein] hydrolase activity Source: InterPro
  8. nucleotide binding Source: UniProtKB-KW
  9. oleoyl-[acyl-carrier-protein] hydrolase activity Source: InterPro
  10. palmitoyl-[acyl-carrier-protein] hydrolase activity Source: InterPro
  11. zinc ion binding Source: InterPro

GO - Biological processi

  1. biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

NADPImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Fatty acid synthaseImported
Gene namesi
Name:FASNImported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

PTM / Processingi

Keywords - PTMi

PhosphopantetheineUniRule annotation

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VZ8X-ray3.22A/B1-2512[»]
2VZ9X-ray3.30A/B1-2512[»]
ProteinModelPortaliA5YV76.
SMRiA5YV76. Positions 422-822, 2121-2206, 2222-2508.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA5YV76.

Family & Domainsi

Sequence similaritiesi

Contains acyl carrier domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG005640.
KOiK00665.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
1.10.1470.20. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.150. 1 hit.
3.40.50.1820. 2 hits.
3.40.50.720. 2 hits.
InterProiIPR029058. AB_hydrolase.
IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR023102. Fatty_acid_synthase_dom_2.
IPR011032. GroES-like.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR013217. Methyltransf_12.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR006162. PPantetheine_attach_site.
IPR029063. SAM-dependent_MTases-like.
IPR001031. Thioesterase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00698. Acyl_transf_1. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF08242. Methyltransf_12. 1 hit.
PF00550. PP-binding. 1 hit.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
SM00822. PKS_KR. 1 hit.
[Graphical view]
SUPFAMiSSF47336. SSF47336. 1 hit.
SSF50129. SSF50129. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF53474. SSF53474. 1 hit.
SSF53901. SSF53901. 2 hits.
SSF55048. SSF55048. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5YV76-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEVVIAGMS GKLPESENLE EFWANLIGGV DMVTADDRRW KAGLYGLPRR
60 70 80 90 100
MGKLKDLSRF DASFFGVHSK QANTMDPQLR MLLEVTYEAI VDGGINPASL
110 120 130 140 150
RGTSTGVWVG VSSSDASEAL SRDPETLVGY SMIGCQRAMM ANRLSFFFDF
160 170 180 190 200
KGPSITIDTA CSSSLLALQS AYQAIRGGEC SAAVVGGLNV LLKPNSSLQF
210 220 230 240 250
MKLGMLSQDG TCRSFDAEGT GYCRAEAVVA VLLTKKSLAR RVYATILNAG
260 270 280 290 300
TNTDGSKEQG VTFPSGDVQE QLIRSLYAPA GPDPESLEYI EAHGTGTKVG
310 320 330 340 350
DPQELNGIVN ALCATRREPL LIGSTKSNMG HPEPASGVAA LIKVLLSLEH
360 370 380 390 400
GVWAPNLHYH TPNPEIPALQ DGRLQVVDRP LPIRGGNVGI NSFGFGGSNV
410 420 430 440 450
HVILQPNSRP APPPAQHAAL PRLLQASGRT LEAVQTLLEQ GLRHSRDLAF
460 470 480 490 500
VGMLNEIAAV SPVAMPFRGY AVLGGEAGSQ EVQQVPGSKR PVWFICSGMG
510 520 530 540 550
AQWQGMGLSL MRLDRFRDSI LRSDQALKPL GLRVSDLLLS TDEAVLDDIV
560 570 580 590 600
SSFVSLTSIQ IALIDLLTSL GLQPDGIIGH SLGEVACGYA DGCLTQEEAV
610 620 630 640 650
LSSYWRGYCI KEANVLPGAM AAVGLSWEEC KQRCPPGIVP ACHNSKDTVT
660 670 680 690 700
ISGPQAAMSE FLQQLKREDV FVKEVRTGGI AFHSYFMESI APTLLRQLRK
710 720 730 740 750
VILDPKPRSK RWLSTSIPEA QWQGSLARTF SAEYSVNNLV SPVLFQEALQ
760 770 780 790 800
HVPAHAVVVE IAPHALLQAV LKRSLESSCT IIPLMKKDHR DNLEFFLSNV
810 820 830 840 850
GRLHLAGVSV NPNGLFPPVE FPAPRGTPLI SPHXKWDHSQ AWDVPSAADF
860 870 880 890 900
PSGSSCSSVA VYKFDVSPES PDHYLVDHCI DGRVLFPGTG YLWLTWKTLA
910 920 930 940 950
RALSQNLEET PVVFEDVTLH QATILPKTGT VSLEVRLLEA SHAFEVSDSN
960 970 980 990 1000
GSLIASGKVY QWESPDPKLF DTRAAVDPAD STAEFRLSQG DVYKDLRLRG
1010 1020 1030 1040 1050
YDYGPFFQLV LESDLEGNRG RLQWNDSWVS FLDAMLHMSI LAPGQLGLYL
1060 1070 1080 1090 1100
PTRFTSIRID PVTHRQKLYT LQDTTQAADV VVDRNLNTVV AGGALFLGAH
1110 1120 1130 1140 1150
SSVAPRRPQE HLKPILEKFC FTPHVESGCL AGNTALQEEL QLCRGLAQAL
1160 1170 1180 1190 1200
QTKVAQQGLK MVVPGLDGAQ APREAPQQSL PRLLAAACQL QLNGNLQLEL
1210 1220 1230 1240 1250
GQVLAQERPL LCDDPLLSGL LDAPALKACV DTALENMASP KMKVVEVLAG
1260 1270 1280 1290 1300
DGQLYSRIPA LLNTQPVMDL DYTATDRNPQ ALEAAQAKLE QLHVTQGQWD
1310 1320 1330 1340 1350
PANPAPGSLG KADLLVCNCA LATLGDPAVA VGNMAATLKE GGFLLLHTLL
1360 1370 1380 1390 1400
AGHPLGEMVG FLTSPEQGGR HLLSQDQWES LFAGASLHLV ALKRSFYGSV
1410 1420 1430 1440 1450
LFLCRQQTPQ DSPVFLSVED TSFRWVDSLK DILADASSRP VWLMAVGCST
1460 1470 1480 1490 1500
SGVVGMVNCL RKEPGGHRIR CVLVSNLSST SPAPEMHPSS SELQKVLQGD
1510 1520 1530 1540 1550
LVMNVYRDGA WGAFRHFPLE QDRPEKQTEH AFVNVLSRGD LSSIRWVCSP
1560 1570 1580 1590 1600
LHYALPASCQ DRLCSVYYTS LNFRDVMLAT GKLSPDSIPG KWLTRDCMLG
1610 1620 1630 1640 1650
MEFSGRDASG RRVMGMVPAE GLATSVLLLQ HATWEVPSTW TLEEAASVPI
1660 1670 1680 1690 1700
VYTTAYYSLV VRGRMQPGES VLIHSGSGGV GQAAIAIALS RGCRVFTTVG
1710 1720 1730 1740 1750
SAEKRAYLQA RFPQLDETCF ANSRDTSFEQ HVLRHTAGKG VDLVLNSLAE
1760 1770 1780 1790 1800
EKLQASVRCL AQHGRFLEIG KFDLSNNHAL GMAVFLKNVT FHGILLDSLF
1810 1820 1830 1840 1850
EEGGATWQEV SELLKAGIQE GVVQPLKCTV FPRTKVEAAF RYMAQGKHIG
1860 1870 1880 1890 1900
KVVIQVREEE QGPAPRGLPP IALTGLSKTF CPPHKSYVIT GGLGGFGLQL
1910 1920 1930 1940 1950
AQWLRLRGAQ KLVLTSRSGI RTGYQARQVR EWRRQGVQVL VSTSNASSLD
1960 1970 1980 1990 2000
GARSLITEAT QLGPVGGVFN LAMVLRDAVL ENQTPEFFQD VSKPKYSGTA
2010 2020 2030 2040 2050
NLDRVTREAC PELDYFVIFS SVSCGRGNAG QANYGFANSA MERICEKRRH
2060 2070 2080 2090 2100
DGLPGLAVQW GAIGDVGVVL ETMGTNDTVI GGTLPQRIAS CLEVLDLFLS
2110 2120 2130 2140 2150
QPHPVLSSFV LAEKKAAAPR DGSSQKDLVK AVAHILGIRD VASINPDSTL
2160 2170 2180 2190 2200
VDLGLDSLMG VEVRQILERE HDLVLSMREV RQLSLRKLQE LSSKTSTDAD
2210 2220 2230 2240 2250
PATPTSHEDS PVRQQATLNL STLLVNPEGP TLTRLNSVQS AERPLFLVHP
2260 2270 2280 2290 2300
IEGSITVFHG LAAKLSIPTY GLQCTGAAPL DSIQSLASYY IECIRQVQPE
2310 2320 2330 2340 2350
GPYRIAGYSY GACVAFEMCS QLQAQQSATP GNHSLFLFDG SHTFVLAYTQ
2360 2370 2380 2390 2400
SVRAKMTPGC EAEAEAKAMY FFVQQFTDME QGKVLEALIP LQGLEARVAA
2410 2420 2430 2440 2450
TVDLITQSHA GLDRHALSFA ARSFYQKLRA AENYWPQATY HGNVTLLRAK
2460 2470 2480 2490 2500
TGGAYGEDLG ADYNLSQVCD GKVSVHVIEG DHRTLLEGSG LESILSIIHS
2510
CLAEPRVSVR EG
Length:2,512
Mass (Da):272,250
Last modified:July 10, 2007 - v1
Checksum:iF57ABBAAC73E4B19
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF589048 mRNA. Translation: ABR09275.1.
RefSeqiNP_001093400.1. NM_001099930.1.
UniGeneiSsc.18175.

Genome annotation databases

GeneIDi397561.
KEGGissc:397561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EF589048 mRNA. Translation: ABR09275.1 .
RefSeqi NP_001093400.1. NM_001099930.1.
UniGenei Ssc.18175.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2VZ8 X-ray 3.22 A/B 1-2512 [» ]
2VZ9 X-ray 3.30 A/B 1-2512 [» ]
ProteinModelPortali A5YV76.
SMRi A5YV76. Positions 422-822, 2121-2206, 2222-2508.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 397561.
KEGGi ssc:397561.

Organism-specific databases

CTDi 2194.

Phylogenomic databases

HOVERGENi HBG005640.
KOi K00665.

Miscellaneous databases

EvolutionaryTracei A5YV76.

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
1.10.1470.20. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.150. 1 hit.
3.40.50.1820. 2 hits.
3.40.50.720. 2 hits.
InterProi IPR029058. AB_hydrolase.
IPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR023102. Fatty_acid_synthase_dom_2.
IPR011032. GroES-like.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR013217. Methyltransf_12.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR006162. PPantetheine_attach_site.
IPR029063. SAM-dependent_MTases-like.
IPR001031. Thioesterase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00698. Acyl_transf_1. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF08242. Methyltransf_12. 1 hit.
PF00550. PP-binding. 1 hit.
PF00975. Thioesterase. 1 hit.
[Graphical view ]
SMARTi SM00829. PKS_ER. 1 hit.
SM00822. PKS_KR. 1 hit.
[Graphical view ]
SUPFAMi SSF47336. SSF47336. 1 hit.
SSF50129. SSF50129. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53335. SSF53335. 1 hit.
SSF53474. SSF53474. 1 hit.
SSF53901. SSF53901. 2 hits.
SSF55048. SSF55048. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Gao L., Chen Z.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The crystal structure of a mammalian fatty acid synthase."
    Maier T., Leibundgut M., Ban N.
    Science 321:1315-1322(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.22 ANGSTROMS) IN COMPLEX WITH NADP.

Entry informationi

Entry nameiA5YV76_PIG
AccessioniPrimary (citable) accession number: A5YV76
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3