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A5YV76 (A5YV76_PIG) Unreviewed, UniProtKB/TrEMBL

Last modified October 16, 2013. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:FASN EMBL ABR09275.1
OrganismSus scrofa (Pig) EMBL ABR09275.1
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length2512 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains acyl carrier domain. SAAS SAAS014030

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding1677 – 16804NADP PDB 2VZ9
Nucleotide binding1723 – 17242NADP PDB 2VZ9
Nucleotide binding1794 – 17963NADP PDB 2VZ9
Nucleotide binding1916 – 19216NADP PDB 2VZ9

Sites

Binding site17001NADP; via amide nitrogen PDB 2VZ9
Binding site17041NADP PDB 2VZ9
Binding site17691NADP; via carbonyl oxygen PDB 2VZ9
Binding site18481NADP PDB 2VZ9
Binding site18961NADP; via amide nitrogen PDB 2VZ9
Binding site19451NADP PDB 2VZ9
Binding site19711NADP; via carbonyl oxygen PDB 2VZ9
Binding site19951NADP PDB 2VZ9
Binding site20191NADP; via carbonyl oxygen PDB 2VZ9
Binding site20631NADP; via amide nitrogen PDB 2VZ9
Binding site20681NADP; via amide nitrogen PDB 2VZ9

Sequences

Sequence LengthMass (Da)Tools
A5YV76 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: F57ABBAAC73E4B19

FASTA2,512272,250
        10         20         30         40         50         60 
MEEVVIAGMS GKLPESENLE EFWANLIGGV DMVTADDRRW KAGLYGLPRR MGKLKDLSRF 

        70         80         90        100        110        120 
DASFFGVHSK QANTMDPQLR MLLEVTYEAI VDGGINPASL RGTSTGVWVG VSSSDASEAL 

       130        140        150        160        170        180 
SRDPETLVGY SMIGCQRAMM ANRLSFFFDF KGPSITIDTA CSSSLLALQS AYQAIRGGEC 

       190        200        210        220        230        240 
SAAVVGGLNV LLKPNSSLQF MKLGMLSQDG TCRSFDAEGT GYCRAEAVVA VLLTKKSLAR 

       250        260        270        280        290        300 
RVYATILNAG TNTDGSKEQG VTFPSGDVQE QLIRSLYAPA GPDPESLEYI EAHGTGTKVG 

       310        320        330        340        350        360 
DPQELNGIVN ALCATRREPL LIGSTKSNMG HPEPASGVAA LIKVLLSLEH GVWAPNLHYH 

       370        380        390        400        410        420 
TPNPEIPALQ DGRLQVVDRP LPIRGGNVGI NSFGFGGSNV HVILQPNSRP APPPAQHAAL 

       430        440        450        460        470        480 
PRLLQASGRT LEAVQTLLEQ GLRHSRDLAF VGMLNEIAAV SPVAMPFRGY AVLGGEAGSQ 

       490        500        510        520        530        540 
EVQQVPGSKR PVWFICSGMG AQWQGMGLSL MRLDRFRDSI LRSDQALKPL GLRVSDLLLS 

       550        560        570        580        590        600 
TDEAVLDDIV SSFVSLTSIQ IALIDLLTSL GLQPDGIIGH SLGEVACGYA DGCLTQEEAV 

       610        620        630        640        650        660 
LSSYWRGYCI KEANVLPGAM AAVGLSWEEC KQRCPPGIVP ACHNSKDTVT ISGPQAAMSE 

       670        680        690        700        710        720 
FLQQLKREDV FVKEVRTGGI AFHSYFMESI APTLLRQLRK VILDPKPRSK RWLSTSIPEA 

       730        740        750        760        770        780 
QWQGSLARTF SAEYSVNNLV SPVLFQEALQ HVPAHAVVVE IAPHALLQAV LKRSLESSCT 

       790        800        810        820        830        840 
IIPLMKKDHR DNLEFFLSNV GRLHLAGVSV NPNGLFPPVE FPAPRGTPLI SPHXKWDHSQ 

       850        860        870        880        890        900 
AWDVPSAADF PSGSSCSSVA VYKFDVSPES PDHYLVDHCI DGRVLFPGTG YLWLTWKTLA 

       910        920        930        940        950        960 
RALSQNLEET PVVFEDVTLH QATILPKTGT VSLEVRLLEA SHAFEVSDSN GSLIASGKVY 

       970        980        990       1000       1010       1020 
QWESPDPKLF DTRAAVDPAD STAEFRLSQG DVYKDLRLRG YDYGPFFQLV LESDLEGNRG 

      1030       1040       1050       1060       1070       1080 
RLQWNDSWVS FLDAMLHMSI LAPGQLGLYL PTRFTSIRID PVTHRQKLYT LQDTTQAADV 

      1090       1100       1110       1120       1130       1140 
VVDRNLNTVV AGGALFLGAH SSVAPRRPQE HLKPILEKFC FTPHVESGCL AGNTALQEEL 

      1150       1160       1170       1180       1190       1200 
QLCRGLAQAL QTKVAQQGLK MVVPGLDGAQ APREAPQQSL PRLLAAACQL QLNGNLQLEL 

      1210       1220       1230       1240       1250       1260 
GQVLAQERPL LCDDPLLSGL LDAPALKACV DTALENMASP KMKVVEVLAG DGQLYSRIPA 

      1270       1280       1290       1300       1310       1320 
LLNTQPVMDL DYTATDRNPQ ALEAAQAKLE QLHVTQGQWD PANPAPGSLG KADLLVCNCA 

      1330       1340       1350       1360       1370       1380 
LATLGDPAVA VGNMAATLKE GGFLLLHTLL AGHPLGEMVG FLTSPEQGGR HLLSQDQWES 

      1390       1400       1410       1420       1430       1440 
LFAGASLHLV ALKRSFYGSV LFLCRQQTPQ DSPVFLSVED TSFRWVDSLK DILADASSRP 

      1450       1460       1470       1480       1490       1500 
VWLMAVGCST SGVVGMVNCL RKEPGGHRIR CVLVSNLSST SPAPEMHPSS SELQKVLQGD 

      1510       1520       1530       1540       1550       1560 
LVMNVYRDGA WGAFRHFPLE QDRPEKQTEH AFVNVLSRGD LSSIRWVCSP LHYALPASCQ 

      1570       1580       1590       1600       1610       1620 
DRLCSVYYTS LNFRDVMLAT GKLSPDSIPG KWLTRDCMLG MEFSGRDASG RRVMGMVPAE 

      1630       1640       1650       1660       1670       1680 
GLATSVLLLQ HATWEVPSTW TLEEAASVPI VYTTAYYSLV VRGRMQPGES VLIHSGSGGV 

      1690       1700       1710       1720       1730       1740 
GQAAIAIALS RGCRVFTTVG SAEKRAYLQA RFPQLDETCF ANSRDTSFEQ HVLRHTAGKG 

      1750       1760       1770       1780       1790       1800 
VDLVLNSLAE EKLQASVRCL AQHGRFLEIG KFDLSNNHAL GMAVFLKNVT FHGILLDSLF 

      1810       1820       1830       1840       1850       1860 
EEGGATWQEV SELLKAGIQE GVVQPLKCTV FPRTKVEAAF RYMAQGKHIG KVVIQVREEE 

      1870       1880       1890       1900       1910       1920 
QGPAPRGLPP IALTGLSKTF CPPHKSYVIT GGLGGFGLQL AQWLRLRGAQ KLVLTSRSGI 

      1930       1940       1950       1960       1970       1980 
RTGYQARQVR EWRRQGVQVL VSTSNASSLD GARSLITEAT QLGPVGGVFN LAMVLRDAVL 

      1990       2000       2010       2020       2030       2040 
ENQTPEFFQD VSKPKYSGTA NLDRVTREAC PELDYFVIFS SVSCGRGNAG QANYGFANSA 

      2050       2060       2070       2080       2090       2100 
MERICEKRRH DGLPGLAVQW GAIGDVGVVL ETMGTNDTVI GGTLPQRIAS CLEVLDLFLS 

      2110       2120       2130       2140       2150       2160 
QPHPVLSSFV LAEKKAAAPR DGSSQKDLVK AVAHILGIRD VASINPDSTL VDLGLDSLMG 

      2170       2180       2190       2200       2210       2220 
VEVRQILERE HDLVLSMREV RQLSLRKLQE LSSKTSTDAD PATPTSHEDS PVRQQATLNL 

      2230       2240       2250       2260       2270       2280 
STLLVNPEGP TLTRLNSVQS AERPLFLVHP IEGSITVFHG LAAKLSIPTY GLQCTGAAPL 

      2290       2300       2310       2320       2330       2340 
DSIQSLASYY IECIRQVQPE GPYRIAGYSY GACVAFEMCS QLQAQQSATP GNHSLFLFDG 

      2350       2360       2370       2380       2390       2400 
SHTFVLAYTQ SVRAKMTPGC EAEAEAKAMY FFVQQFTDME QGKVLEALIP LQGLEARVAA 

      2410       2420       2430       2440       2450       2460 
TVDLITQSHA GLDRHALSFA ARSFYQKLRA AENYWPQATY HGNVTLLRAK TGGAYGEDLG 

      2470       2480       2490       2500       2510 
ADYNLSQVCD GKVSVHVIEG DHRTLLEGSG LESILSIIHS CLAEPRVSVR EG 

« Hide

References

[1]Gao L., Chen Z.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"The crystal structure of a mammalian fatty acid synthase."
Maier T., Leibundgut M., Ban N.
Science 321:1315-1322(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.22 ANGSTROMS) IN COMPLEX WITH NADP.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF589048 mRNA. Translation: ABR09275.1.
RefSeqNP_001093400.1. NM_001099930.1.
UniGeneSsc.18175.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2VZ8X-ray3.22A/B1-2512[»]
2VZ9X-ray3.30A/B1-2512[»]
ProteinModelPortalA5YV76.
SMRA5YV76. Positions 422-822, 2121-2206, 2222-2508.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397561.
KEGGssc:397561.

Organism-specific databases

CTD2194.

Phylogenomic databases

HOVERGENHBG005640.
KOK00665.

Family and domain databases

Gene3D1.10.1200.10. 1 hit.
1.10.1470.20. 1 hit.
3.40.366.10. 2 hits.
3.40.47.10. 2 hits.
3.40.50.720. 2 hits.
InterProIPR001227. Ac_transferase_dom.
IPR009081. Acyl_carrier_prot-like.
IPR014043. Acyl_transferase.
IPR016035. Acyl_Trfase/lysoPLipase.
IPR013149. ADH_C.
IPR023102. Fatty_acid_synthase_dom_2.
IPR011032. GroES-like.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016036. Malonyl_transacylase_ACP-bd.
IPR013217. Methyltransf_12.
IPR016040. NAD(P)-bd_dom.
IPR020842. PKS/FAS_KR.
IPR020843. PKS_ER.
IPR013968. PKS_KR.
IPR006162. PPantetheine_attach_site.
IPR001031. Thioesterase.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00698. Acyl_transf_1. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
PF08659. KR. 1 hit.
PF08242. Methyltransf_12. 1 hit.
PF00550. PP-binding. 1 hit.
PF00975. Thioesterase. 1 hit.
[Graphical view]
SMARTSM00829. PKS_ER. 1 hit.
SM00822. PKS_KR. 1 hit.
[Graphical view]
SUPFAMSSF47336. SSF47336. 1 hit.
SSF50129. SSF50129. 1 hit.
SSF52151. SSF52151. 2 hits.
SSF53901. SSF53901. 2 hits.
SSF55048. SSF55048. 1 hit.
PROSITEPS50075. ACP_DOMAIN. 1 hit.
PS00606. B_KETOACYL_SYNTHASE. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceA5YV76.

Entry information

Entry nameA5YV76_PIG
AccessionPrimary (citable) accession number: A5YV76
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 16, 2013
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)