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A5YMU1

- A5YMU1_MOUSE

UniProt

A5YMU1 - A5YMU1_MOUSE

Protein

Cytochrome c oxidase subunit 1

Gene

COXI

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Electron transport, Respiratory chainUniRule annotation, Transport

    Keywords - Ligandi

    CopperUniRule annotation, HemeUniRule annotation, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
    Gene namesi
    Name:COXIImported
    Encoded oniMitochondrionImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Subcellular locationi

    Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain complex IV Source: Ensembl

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

    Expressioni

    Gene expression databases

    BgeeiA5YMU1.
    GenevestigatoriA5YMU1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heme-copper respiratory oxidase family.UniRule annotation

    Keywords - Domaini

    TransmembraneUniRule annotation

    Phylogenomic databases

    HOVERGENiHBG102108.
    InParanoidiA5YMU1.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    A5YMU1-1 [UniParc]FASTAAdd to Basket

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    WAGMVGTALS ILIRAELGQP GALLGDDQIY NVIVTAHAFV MIFFMVMPMM    50
    IGGFGNWLVP LMIGAPDMAF PRMNNMSFWL LPPSFLLLLA SSMVEAGAGT 100
    GWTVYPPLAG NLAHAGASVD LTIFSLHLAG VSSILGAINF ITTIINMKPP 150
    AMTQYQTPLF VWSVLITAVL LLLSLPVLAA GITMLLTDRN LNTTFFDPAG 200
    GGDP 204
    Length:204
    Mass (Da):21,668
    Last modified:July 10, 2007 - v1
    Checksum:i8FBA529A0265F839
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei204 – 2041Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF568645 Genomic DNA. Translation: ABQ81554.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EF568645 Genomic DNA. Translation: ABQ81554.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG102108.
    InParanoidi A5YMU1.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Miscellaneous databases

    NextBioi 35544846.

    Gene expression databases

    Bgeei A5YMU1.
    Genevestigatori A5YMU1.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The use of DNA barcoding for species identification of materials housed in a biorepository."
      Lorenz J.G., Yancy H., Coppock D.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiA5YMU1_MOUSE
    AccessioniPrimary (citable) accession number: A5YMU1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)