Reviewed, UniProtKB/Swiss-Prot A5YM69 (ARG5L_HUMAN)

Names and origin

Protein names

Recommended name:
    Rho guanine nucleotide exchange factor 5-like protein

Gene names

Name:

ARHGEF5L

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	484 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Ontologies

Keywords
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 484	484	Rho guanine nucleotide exchange factor 5-like protein		PRO_0000348462
Regions
	Compositional bias	146 – 401	256	Glu-rich
Amino acid modifications
	Modified residue	184	1	Phosphoserine Ref.4
Experimental info
	Sequence conflict	8	1	H → R in BAC86243. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	A5YM69-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: B495D13224E9E52C	FASTA	484	53,287
	10 20 30 40 50 60 MEAEEAQHGA SPPISAIEEF SIIPEAPMRS SQVSALGLEA QEDEDPSYKW REEHRLSATQ 70 80 90 100 110 120 QSELRDVCDY AIETMPSFPK EGSADVEPNQ ESLVAEACDT PEHWEAVPQS LAGRQARTLA 130 140 150 160 170 180 PPELWACPIQ SEHLDMAPFS SDLGSEEEEV EFWPGLTSLT LGSGQAEEEE ETSSDNSGQT 190 200 210 220 230 240 RYYSPCEEHP AETNQNEGAE SGTIRQGEEL PSEELQESQG LLHPQEVQVL EEQGQQEAGF 250 260 270 280 290 300 RGEGTLREDV CADGLLGEEQ MIEQVNDEKG EQKQKQEQVQ DVMLGRQGER MGLTGEPEGL 310 320 330 340 350 360 NDGEWEQEDM ERKAQGQGGP EQGEERKREL QVPEENRADS QDEKSQTFLG KSEEVTGKQE 370 380 390 400 410 420 DHGIKEKGVP VSGQEAKEPE SWDGGRLGAV GRARSREEEN EHHGPSMPAL IAPEDSPHCD 430 440 450 460 470 480 LFPGASYLVT QIPGTQTESR AEELSPAALS PLLEPIRCSH QPISLLGSFL TEESPDKEKL LSVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Schupp I. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	EF560743 mRNA. Translation: ABQ59053.1. AK125680 mRNA. Translation: BAC86243.1. BC136868 mRNA. Translation: AAI36869.1. BC136878 mRNA. Translation: AAI36879.1.
IPI	IPI00419046.
RefSeq	NP_001003702.1.
UniGene	Hs.534621
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	A5YM69.
Genome annotation databases
Ensembl	ENST00000378115; ENSP00000367355; ENSG00000213214; Homo sapiens. [Genome view]
GeneID	445328.
KEGG	hsa:445328.
UCSC	uc003wdz.1. human.
Organism-specific databases
CTD	445328.
GeneCards	GC07M143515.
HGNC	HGNC:33846. ARHGEF5L.
GenAtlas	Search...
Phylogenomic databases
OrthoDB	EOG9VHNTG
Gene expression databases
Bgee	A5YM69.
Genevestigator	A5YM69.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

ARG5L_HUMAN

Accession

Primary (citable) accession number: A5YM69
Secondary accession number(s): Q6ZUI2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	July 10, 2007
Last modified:	November 24, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.