A5YM69 (ARG35_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 33.
History...
Clusters with 
Names·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Rho guanine nucleotide exchange factor 35 Alternative name(s): Rho guanine nucleotide exchange factor 5-like protein | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 484 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
Ontologies
| Keywords | |
|---|---|
| PTM | Phosphoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 484 | 484 | Rho guanine nucleotide exchange factor 35 | PRO_0000348462 | |||||
Regions | |||||||||
| Compositional bias | 146 – 401 | 256 | Glu-rich | ||||||
Amino acid modifications | |||||||||
| Modified residue | 182 | 1 | Phosphotyrosine Ref.4 | ||||||
| Modified residue | 184 | 1 | Phosphoserine Ref.5 | ||||||
Experimental info | |||||||||
| Sequence conflict | 8 | 1 | H → R in BAC86243. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Schupp I. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.  Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Mammary gland. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | "Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networks." Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M. Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007) [PubMed: 17389395] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-182, MASS SPECTROMETRY. Tissue: Mammary epithelium. |
| [5] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-184, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | EF560743 mRNA. Translation: ABQ59053.1. AK125680 mRNA. Translation: BAC86243.1. BC136868 mRNA. Translation: AAI36869.1. BC136878 mRNA. Translation: AAI36879.1. |
| IPI | IPI00419046. |
| RefSeq | NP_001003702.2. NM_001003702.2. |
| UniGene | Hs.534621. |
3D structure databases | |
| ProteinModelPortal | A5YM69. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A5YM69. |
PTM databases | |
| PhosphoSite | A5YM69. |
Proteomic databases | |
| PRIDE | A5YM69. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000378115; ENSP00000367355; ENSG00000213214. |
| GeneID | 445328. |
| KEGG | hsa:445328. |
| UCSC | uc003wdz.1. human. |
Organism-specific databases | |
| CTD | 445328. |
| GeneCards | GC07M143883. |
| HGNC | HGNC:33846. ARHGEF35. |
| neXtProt | NX_A5YM69. |
| PharmGKB | PA165617645. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG13542. |
| GeneTree | ENSGT00550000076107. |
| HOGENOM | HBG506945. |
| OrthoDB | EOG4NP74S. |
Gene expression databases | |
| Bgee | A5YM69. |
| Genevestigator | A5YM69. |
Family and domain databases | |
| ProtoNet | Search... |
Entry information
| Entry name | ARG35_HUMAN | ||||||||
| Accession | Primary (citable) accession number: A5YM69 Secondary accession number(s): Q6ZUI2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |