A5YKK6 (CNOT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CCR4-NOT transcription complex subunit 1

Alternative name(s):
CCR4-associated factor 1
Negative regulator of transcription subunit 1 homolog
Short name=NOT1H
Short name=hNOT1

Gene names

Name:	CNOT1
Synonyms:	CDC39, KIAA1007, NOT1
ORF Names:	AD-005

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2376 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity. Ref.7 Ref.8 Ref.13 Ref.14 Ref.15 Ref.16
Subunit structure	Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2, TOB1 and ZFP36. Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct. Ref.7 Ref.8 Ref.9 Ref.10 Ref.12 Ref.13 Ref.14 Ref.17
Subcellular location	Cytoplasm › P-body. Nucleus Probable. Note: NANOS2 promotes its localization to P-body By similarity. Ref.15
Tissue specificity	Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon. Ref.7
Developmental stage	Expressed in embryonic stem (ES) cells. Ref.16
Domain	Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors. Ref.8
Sequence similarities	Belongs to the CNOT1 family.
Sequence caution	The sequence AAF14861.1 differs from that shown. Reason: Frameshift at positions 1969 and 2273. The sequence CAH18093.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	RNA-mediated gene silencing Transcription Transcription regulation Translation regulation
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Developmental protein Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of intracellular estrogen receptor signaling pathway Inferred from direct assay Ref.8. Source: UniProtKB negative regulation of retinoic acid receptor signaling pathway Inferred from direct assay Ref.8. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay Ref.8. Source: UniProtKB nuclear-transcribed mRNA poly(A) tail shortening Traceable author statement. Source: Reactome positive regulation of cytoplasmic mRNA processing body assembly Inferred from direct assay Ref.15. Source: UniProtKB positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Inferred from mutant phenotype Ref.14. Source: UniProtKB positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Inferred from mutant phenotype Ref.14. Source: UniProtKB regulation of stem cell maintenance Inferred from mutant phenotype Ref.16. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	CCR4-NOT complex Inferred from direct assay Ref.10. Source: UniProtKB cytoplasmic mRNA processing body Inferred from direct assay Ref.15. Source: UniProtKB cytosol Traceable author statement. Source: Reactome peroxisomal membrane Inferred from direct assay PubMed 21525035. Source: UniProtKB
Molecular_function	estrogen receptor binding Inferred from direct assay Ref.8. Source: UniProtKB retinoic acid receptor binding Inferred from direct assay Ref.8. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CNOT11	Q9UKZ1	3	EBI-1222758,EBI-2562014
CNOT6	Q9ULM6	2	EBI-1222758,EBI-2104530
CNOT6L	Q96LI5	2	EBI-1222758,EBI-1046635
CNOT7	Q9UIV1	6	EBI-1222758,EBI-2105113
CNOT8	Q9UFF9	3	EBI-1222758,EBI-742299
TNRC6A	Q8NDV7	2	EBI-1222758,EBI-2269715
TNRC6B	Q9UPQ9	4	EBI-1222758,EBI-947158
TNRC6C	Q9HCJ0	4	EBI-1222758,EBI-6507625
TOB1	P50616	3	EBI-1222758,EBI-723281
Zfp36	P22893	5	EBI-1222758,EBI-647803	From a different organism.

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A5YKK6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A5YKK6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     822-827: SKMKPS → T

Isoform 3 (identifier: A5YKK6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     822-827: SKMKPS → T
     2152-2155: VDML → SLTL
     2156-2376: Missing.

Isoform 4 (identifier: A5YKK6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1479-1551: TASPQQREMM...DPVVLTYQAE → VSWLFPWYRY...FFLLYSQHDV
     1552-2376: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 2376

2376

CCR4-NOT transcription complex subunit 1

PRO_0000315541

Regions

Region

1090 – 1605

516

Interaction with CNOT6, CNOT6L, CNOT7 and CNOT8

Motif

153 – 157

5

LXXLL

Motif

181 – 185

5

LXXLL

Motif

223 – 227

5

LXXLL

Motif

570 – 574

5

LXXLL

Motif

1639 – 1643

5

LXXLL

Motif

1942 – 1946

5

LXXLL

Motif

2096 – 2100

5

LXXLL

Compositional bias

1333 – 1350

18

Thr-rich

Natural variations

Alternative sequence

822 – 827

6

SKMKPS → T in isoform 2 and isoform 3.

VSP_030559

Alternative sequence

1479 – 1551

73

TASPQ…TYQAE → VSWLFPWYRYKTYYCLSVII FFFVYIWHWALPLILNNHHI CLMSSIILDCNSVRQSIMSV CFFFFLLYSQHDV in isoform 4.

VSP_030560

Alternative sequence

1552 – 2376

825

Missing in isoform 4.

VSP_030561

Alternative sequence

2152 – 2155

4

VDML → SLTL in isoform 3.

VSP_030562

Alternative sequence

2156 – 2376

221

Missing in isoform 3.

VSP_030563

Natural variant

603

1

D → A. Ref.3
Corresponds to variant rs17854028 [ dbSNP | Ensembl ].

VAR_038254

Experimental info

Mutagenesis

1208

1

K → E: Impairs interaction with CNOT7; when associated with Y-1212 and E-1218. Ref.17

Mutagenesis

1209

1

P → Y: Abolishes interaction with CNOT7; when associated with Y-1257.

Mutagenesis

1212

1

H → Y: Impairs interaction with CNOT7; when associated with E-1208 and E-1218. Ref.17

Mutagenesis

1218

1

K → E: Impairs interaction with CNOT7; when associated with E-1208 and Y-1212. Ref.17

Mutagenesis

1251

1

V → R: Abolishes interaction with CNOT7.

Mutagenesis

1257

1

P → Y: Abolishes interaction with CNOT7; when associated with Y-1209.

Sequence conflict

18

1

D → G in CAD97851. Ref.1

Sequence conflict

323

1

D → G in CAD97851. Ref.1

Sequence conflict

922

1

E → G in ABQ66268. Ref.1

Sequence conflict

1063

1

K → R in CAH18093. Ref.1

Sequence conflict

1417

1

M → V in CAD97851. Ref.1

Sequence conflict

1799

1

R → G in CAD97851. Ref.1

Sequence conflict

1936

1

L → P in CAH18093. Ref.1

Sequence conflict

2198 – 2200

3

SNL → RTV in AAF14861. Ref.6

Sequence conflict

2358

1

Q → R in ABQ66268. Ref.1

Secondary structure

1

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2376

Helix Strand Turn

Details...

Helix

1093 – 1104

12

Turn

1108 – 1110

3

Helix

1111 – 1121

11

Helix

1124 – 1126

3

Helix

1127 – 1137

11

Turn

1138 – 1141

4

Helix

1143 – 1145

3

Helix

1146 – 1156

11

Helix

1159 – 1177

19

Helix

1186 – 1202

17

Helix

1204 – 1206

3

Turn

1212 – 1214

3

Helix

1217 – 1227

11

Helix

1229 – 1244

16

Turn

1245 – 1248

4

Turn

1250 – 1252

3

Helix

1257 – 1271

15

Helix

1277 – 1289

13

Helix

1294 – 1296

3

Helix

1302 – 1304

3

Helix

1309 – 1311

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 937A0899537BA615	FASTA	2,376	266,939
	10 20 30 40 50 60 MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC LFSHVDFSGD 70 80 90 100 110 120 GKSSGKDFHQ TQFLIQECAL LITKPNFIST LSYAIDNPLH YQKSLKPAPH LFAQLSKVLK 130 140 150 160 170 180 LSKVQEVIFG LALLNSSSSD LRGFAAQFIK QKLPDLLRSY IDADVSGNQE GGFQDIAIEV 190 200 210 220 230 240 LHLLLSHLLF GQKGAFGVGQ EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL 250 260 270 280 290 300 PDSGGVAKTM MESSLADFMQ EVGYGFCASI EECRNIIVQF GVREVTAAQV ARVLGMMART 310 320 330 340 350 360 HSGLTDGIPL QSISAPGSGI WSDGKDKSDG AQAHTWNVEV LIDVLKELNP SLNFKEVTYE 370 380 390 400 410 420 LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDLIYRPWK HAEGQLSFIQ HSLINPEIFC 430 440 450 460 470 480 FADYPCHTVA TDILKAPPED DNREIATWKS LDLIESLLRL AEVGQYEQVK QLFSFPIKHC 490 500 510 520 530 540 PDMLVLALLQ INTSWHTLRH ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH 550 560 570 580 590 600 AMAEWYMRGE QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW 610 620 630 640 650 660 LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT MLACLQACAG 670 680 690 700 710 720 SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA SSLDAISPVQ IDPLAGMTSL 730 740 750 760 770 780 SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP AKAFPPLSTP NQTTAFSGIG GLSSQLPVGG 790 800 810 820 830 840 LGTGSLTGIG TGALGLPAVN NDPFVQRKLG TSGLNQPTFQ QSKMKPSDLS QVWPEANQHF 850 860 870 880 890 900 SKEIDDEANS YFQRIYNHPP HPTMSVDEVL EMLQRFKDST IKREREVFNC MLRNLFEEYR 910 920 930 940 950 960 FFPQYPDKEL HITACLFGGI IEKGLVTYMA LGLALRYVLE ALRKPFGSKM YYFGIAALDR 970 980 990 1000 1010 1020 FKNRLKDYPQ YCQHLASISH FMQFPHHLQE YIEYGQQSRD PPVKMQGSIT TPGSIALAQA 1030 1040 1050 1060 1070 1080 QAQAQVPAKA PLAGQVSTMV TTSTTTTVAK TVTVTRPTGV SFKKDVPPSI NTTNIDTLLV 1090 1100 1110 1120 1130 1140 ATDQTERIVE PPENIQEKIA FIFNNLSQSN MTQKVEELKE TVKEEFMPWV SQYLVMKRVS 1150 1160 1170 1180 1190 1200 IEPNFHSLYS NFLDTLKNPE FNKMVLNETY RNIKVLLTSD KAAANFSDRS LLKNLGHWLG 1210 1220 1230 1240 1250 1260 MITLAKNKPI LHTDLDVKSL LLEAYVKGQQ ELLYVVPFVA KVLESSIRSV VFRPPNPWTM 1270 1280 1290 1300 1310 1320 AIMNVLAELH QEHDLKLNLK FEIEVLCKNL ALDINELKPG NLLKDKDRLK NLDEQLSAPK 1330 1340 1350 1360 1370 1380 KDVKQPEELP PITTTTTSTT PATNTTCTAT VPPQPQYSYH DINVYSLAGL APHITLNPTI 1390 1400 1410 1420 1430 1440 PLFQAHPQLK QCVRQAIERA VQELVHPVVD RSIKIAMTTC EQIVRKDFAL DSEESRMRIA 1450 1460 1470 1480 1490 1500 AHHMMRNLTA GMAMITCREP LLMSISTNLK NSFASALRTA SPQQREMMDQ AAAQLAQDNC 1510 1520 1530 1540 1550 1560 ELACCFIQKT AVEKAGPEMD KRLATEFELR KHARQEGRRY CDPVVLTYQA ERMPEQIRLK 1570 1580 1590 1600 1610 1620 VGGVDPKQLA VYEEFARNVP GFLPTNDLSQ PTGFLAQPMK QAWATDDVAQ IYDKCITELE 1630 1640 1650 1660 1670 1680 QHLHAIPPTL AMNPQAQALR SLLEVVVLSR NSRDAIAALG LLQKAVEGLL DATSGADADL 1690 1700 1710 1720 1730 1740 LLRYRECHLL VLKALQDGRA YGSPWCNKQI TRCLIECRDE YKYNVEAVEL LIRNHLVNMQ 1750 1760 1770 1780 1790 1800 QYDLHLAQSM ENGLNYMAVA FAMQLVKILL VDERSVAHVT EADLFHTIET LMRINAHSRG 1810 1820 1830 1840 1850 1860 NAPEGLPQLM EVVRSNYEAM IDRAHGGPNF MMHSGISQAS EYDDPPGLRE KAEYLLREWV 1870 1880 1890 1900 1910 1920 NLYHSAAAGR DSTKAFSAFV GQMHQQGILK TDDLITRFFR LCTEMCVEIS YRAQAEQQHN 1930 1940 1950 1960 1970 1980 PAANPTMIRA KCYHNLDAFV RLIALLVKHS GEATNTVTKI NLLNKVLGIV VGVLLQDHDV 1990 2000 2010 2020 2030 2040 RQSEFQQLPY HRIFIMLLLE LNAPEHVLET INFQTLTAFC NTFHILRPTK APGFVYAWLE 2050 2060 2070 2080 2090 2100 LISHRIFIAR MLAHTPQQKG WPMYAQLLID LFKYLAPFLR NVELTKPMQI LYKGTLRVLL 2110 2120 2130 2140 2150 2160 VLLHDFPEFL CDYHYGFCDV IPPNCIQLRN LILSAFPRNM RLPDPFTPNL KVDMLSEINI 2170 2180 2190 2200 2210 2220 APRILTNFTG VMPPQFKKDL DSYLKTRSPV TFLSDLRSNL QVSNEPGNRY NLQLINALVL 2230 2240 2250 2260 2270 2280 YVGTQAIAHI HNKGSTPSMS TITHSAHMDI FQNLAVDLDT EGRYLFLNAI ANQLRYPNSH 2290 2300 2310 2320 2330 2340 THYFSCTMLY LFAEANTEAI QEQITRVLLE RLIVNRPHPW GLLITFIELI KNPAFKFWNH 2350 2360 2370 EFVHCAPEIE KLFQSVAQCC MGQKQAQQVM EGTGAS
	Isoform 2 [UniParc]. Checksum: 23D129C7F9CE775B	FASTA	2,371	266,381
	10 20 30 40 50 60 MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC LFSHVDFSGD 70 80 90 100 110 120 GKSSGKDFHQ TQFLIQECAL LITKPNFIST LSYAIDNPLH YQKSLKPAPH LFAQLSKVLK 130 140 150 160 170 180 LSKVQEVIFG LALLNSSSSD LRGFAAQFIK QKLPDLLRSY IDADVSGNQE GGFQDIAIEV 190 200 210 220 230 240 LHLLLSHLLF GQKGAFGVGQ EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL 250 260 270 280 290 300 PDSGGVAKTM MESSLADFMQ EVGYGFCASI EECRNIIVQF GVREVTAAQV ARVLGMMART 310 320 330 340 350 360 HSGLTDGIPL QSISAPGSGI WSDGKDKSDG AQAHTWNVEV LIDVLKELNP SLNFKEVTYE 370 380 390 400 410 420 LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDLIYRPWK HAEGQLSFIQ HSLINPEIFC 430 440 450 460 470 480 FADYPCHTVA TDILKAPPED DNREIATWKS LDLIESLLRL AEVGQYEQVK QLFSFPIKHC 490 500 510 520 530 540 PDMLVLALLQ INTSWHTLRH ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH 550 560 570 580 590 600 AMAEWYMRGE QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW 610 620 630 640 650 660 LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT MLACLQACAG 670 680 690 700 710 720 SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA SSLDAISPVQ IDPLAGMTSL 730 740 750 760 770 780 SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP AKAFPPLSTP NQTTAFSGIG GLSSQLPVGG 790 800 810 820 830 840 LGTGSLTGIG TGALGLPAVN NDPFVQRKLG TSGLNQPTFQ QTDLSQVWPE ANQHFSKEID 850 860 870 880 890 900 DEANSYFQRI YNHPPHPTMS VDEVLEMLQR FKDSTIKRER EVFNCMLRNL FEEYRFFPQY 910 920 930 940 950 960 PDKELHITAC LFGGIIEKGL VTYMALGLAL RYVLEALRKP FGSKMYYFGI AALDRFKNRL 970 980 990 1000 1010 1020 KDYPQYCQHL ASISHFMQFP HHLQEYIEYG QQSRDPPVKM QGSITTPGSI ALAQAQAQAQ 1030 1040 1050 1060 1070 1080 VPAKAPLAGQ VSTMVTTSTT TTVAKTVTVT RPTGVSFKKD VPPSINTTNI DTLLVATDQT 1090 1100 1110 1120 1130 1140 ERIVEPPENI QEKIAFIFNN LSQSNMTQKV EELKETVKEE FMPWVSQYLV MKRVSIEPNF 1150 1160 1170 1180 1190 1200 HSLYSNFLDT LKNPEFNKMV LNETYRNIKV LLTSDKAAAN FSDRSLLKNL GHWLGMITLA 1210 1220 1230 1240 1250 1260 KNKPILHTDL DVKSLLLEAY VKGQQELLYV VPFVAKVLES SIRSVVFRPP NPWTMAIMNV 1270 1280 1290 1300 1310 1320 LAELHQEHDL KLNLKFEIEV LCKNLALDIN ELKPGNLLKD KDRLKNLDEQ LSAPKKDVKQ 1330 1340 1350 1360 1370 1380 PEELPPITTT TTSTTPATNT TCTATVPPQP QYSYHDINVY SLAGLAPHIT LNPTIPLFQA 1390 1400 1410 1420 1430 1440 HPQLKQCVRQ AIERAVQELV HPVVDRSIKI AMTTCEQIVR KDFALDSEES RMRIAAHHMM 1450 1460 1470 1480 1490 1500 RNLTAGMAMI TCREPLLMSI STNLKNSFAS ALRTASPQQR EMMDQAAAQL AQDNCELACC 1510 1520 1530 1540 1550 1560 FIQKTAVEKA GPEMDKRLAT EFELRKHARQ EGRRYCDPVV LTYQAERMPE QIRLKVGGVD 1570 1580 1590 1600 1610 1620 PKQLAVYEEF ARNVPGFLPT NDLSQPTGFL AQPMKQAWAT DDVAQIYDKC ITELEQHLHA 1630 1640 1650 1660 1670 1680 IPPTLAMNPQ AQALRSLLEV VVLSRNSRDA IAALGLLQKA VEGLLDATSG ADADLLLRYR 1690 1700 1710 1720 1730 1740 ECHLLVLKAL QDGRAYGSPW CNKQITRCLI ECRDEYKYNV EAVELLIRNH LVNMQQYDLH 1750 1760 1770 1780 1790 1800 LAQSMENGLN YMAVAFAMQL VKILLVDERS VAHVTEADLF HTIETLMRIN AHSRGNAPEG 1810 1820 1830 1840 1850 1860 LPQLMEVVRS NYEAMIDRAH GGPNFMMHSG ISQASEYDDP PGLREKAEYL LREWVNLYHS 1870 1880 1890 1900 1910 1920 AAAGRDSTKA FSAFVGQMHQ QGILKTDDLI TRFFRLCTEM CVEISYRAQA EQQHNPAANP 1930 1940 1950 1960 1970 1980 TMIRAKCYHN LDAFVRLIAL LVKHSGEATN TVTKINLLNK VLGIVVGVLL QDHDVRQSEF 1990 2000 2010 2020 2030 2040 QQLPYHRIFI MLLLELNAPE HVLETINFQT LTAFCNTFHI LRPTKAPGFV YAWLELISHR 2050 2060 2070 2080 2090 2100 IFIARMLAHT PQQKGWPMYA QLLIDLFKYL APFLRNVELT KPMQILYKGT LRVLLVLLHD 2110 2120 2130 2140 2150 2160 FPEFLCDYHY GFCDVIPPNC IQLRNLILSA FPRNMRLPDP FTPNLKVDML SEINIAPRIL 2170 2180 2190 2200 2210 2220 TNFTGVMPPQ FKKDLDSYLK TRSPVTFLSD LRSNLQVSNE PGNRYNLQLI NALVLYVGTQ 2230 2240 2250 2260 2270 2280 AIAHIHNKGS TPSMSTITHS AHMDIFQNLA VDLDTEGRYL FLNAIANQLR YPNSHTHYFS 2290 2300 2310 2320 2330 2340 CTMLYLFAEA NTEAIQEQIT RVLLERLIVN RPHPWGLLIT FIELIKNPAF KFWNHEFVHC 2350 2360 2370 APEIEKLFQS VAQCCMGQKQ AQQVMEGTGA S
	Isoform 3 [UniParc]. Checksum: BBB731593591523C	FASTA	2,150	241,260
	10 20 30 40 50 60 MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC LFSHVDFSGD 70 80 90 100 110 120 GKSSGKDFHQ TQFLIQECAL LITKPNFIST LSYAIDNPLH YQKSLKPAPH LFAQLSKVLK 130 140 150 160 170 180 LSKVQEVIFG LALLNSSSSD LRGFAAQFIK QKLPDLLRSY IDADVSGNQE GGFQDIAIEV 190 200 210 220 230 240 LHLLLSHLLF GQKGAFGVGQ EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL 250 260 270 280 290 300 PDSGGVAKTM MESSLADFMQ EVGYGFCASI EECRNIIVQF GVREVTAAQV ARVLGMMART 310 320 330 340 350 360 HSGLTDGIPL QSISAPGSGI WSDGKDKSDG AQAHTWNVEV LIDVLKELNP SLNFKEVTYE 370 380 390 400 410 420 LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDLIYRPWK HAEGQLSFIQ HSLINPEIFC 430 440 450 460 470 480 FADYPCHTVA TDILKAPPED DNREIATWKS LDLIESLLRL AEVGQYEQVK QLFSFPIKHC 490 500 510 520 530 540 PDMLVLALLQ INTSWHTLRH ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH 550 560 570 580 590 600 AMAEWYMRGE QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW 610 620 630 640 650 660 LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT MLACLQACAG 670 680 690 700 710 720 SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA SSLDAISPVQ IDPLAGMTSL 730 740 750 760 770 780 SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP AKAFPPLSTP NQTTAFSGIG GLSSQLPVGG 790 800 810 820 830 840 LGTGSLTGIG TGALGLPAVN NDPFVQRKLG TSGLNQPTFQ QTDLSQVWPE ANQHFSKEID 850 860 870 880 890 900 DEANSYFQRI YNHPPHPTMS VDEVLEMLQR FKDSTIKRER EVFNCMLRNL FEEYRFFPQY 910 920 930 940 950 960 PDKELHITAC LFGGIIEKGL VTYMALGLAL RYVLEALRKP FGSKMYYFGI AALDRFKNRL 970 980 990 1000 1010 1020 KDYPQYCQHL ASISHFMQFP HHLQEYIEYG QQSRDPPVKM QGSITTPGSI ALAQAQAQAQ 1030 1040 1050 1060 1070 1080 VPAKAPLAGQ VSTMVTTSTT TTVAKTVTVT RPTGVSFKKD VPPSINTTNI DTLLVATDQT 1090 1100 1110 1120 1130 1140 ERIVEPPENI QEKIAFIFNN LSQSNMTQKV EELKETVKEE FMPWVSQYLV MKRVSIEPNF 1150 1160 1170 1180 1190 1200 HSLYSNFLDT LKNPEFNKMV LNETYRNIKV LLTSDKAAAN FSDRSLLKNL GHWLGMITLA 1210 1220 1230 1240 1250 1260 KNKPILHTDL DVKSLLLEAY VKGQQELLYV VPFVAKVLES SIRSVVFRPP NPWTMAIMNV 1270 1280 1290 1300 1310 1320 LAELHQEHDL KLNLKFEIEV LCKNLALDIN ELKPGNLLKD KDRLKNLDEQ LSAPKKDVKQ 1330 1340 1350 1360 1370 1380 PEELPPITTT TTSTTPATNT TCTATVPPQP QYSYHDINVY SLAGLAPHIT LNPTIPLFQA 1390 1400 1410 1420 1430 1440 HPQLKQCVRQ AIERAVQELV HPVVDRSIKI AMTTCEQIVR KDFALDSEES RMRIAAHHMM 1450 1460 1470 1480 1490 1500 RNLTAGMAMI TCREPLLMSI STNLKNSFAS ALRTASPQQR EMMDQAAAQL AQDNCELACC 1510 1520 1530 1540 1550 1560 FIQKTAVEKA GPEMDKRLAT EFELRKHARQ EGRRYCDPVV LTYQAERMPE QIRLKVGGVD 1570 1580 1590 1600 1610 1620 PKQLAVYEEF ARNVPGFLPT NDLSQPTGFL AQPMKQAWAT DDVAQIYDKC ITELEQHLHA 1630 1640 1650 1660 1670 1680 IPPTLAMNPQ AQALRSLLEV VVLSRNSRDA IAALGLLQKA VEGLLDATSG ADADLLLRYR 1690 1700 1710 1720 1730 1740 ECHLLVLKAL QDGRAYGSPW CNKQITRCLI ECRDEYKYNV EAVELLIRNH LVNMQQYDLH 1750 1760 1770 1780 1790 1800 LAQSMENGLN YMAVAFAMQL VKILLVDERS VAHVTEADLF HTIETLMRIN AHSRGNAPEG 1810 1820 1830 1840 1850 1860 LPQLMEVVRS NYEAMIDRAH GGPNFMMHSG ISQASEYDDP PGLREKAEYL LREWVNLYHS 1870 1880 1890 1900 1910 1920 AAAGRDSTKA FSAFVGQMHQ QGILKTDDLI TRFFRLCTEM CVEISYRAQA EQQHNPAANP 1930 1940 1950 1960 1970 1980 TMIRAKCYHN LDAFVRLIAL LVKHSGEATN TVTKINLLNK VLGIVVGVLL QDHDVRQSEF 1990 2000 2010 2020 2030 2040 QQLPYHRIFI MLLLELNAPE HVLETINFQT LTAFCNTFHI LRPTKAPGFV YAWLELISHR 2050 2060 2070 2080 2090 2100 IFIARMLAHT PQQKGWPMYA QLLIDLFKYL APFLRNVELT KPMQILYKGT LRVLLVLLHD 2110 2120 2130 2140 2150 FPEFLCDYHY GFCDVIPPNC IQLRNLILSA FPRNMRLPDP FTPNLKSLTL
	Isoform 4 [UniParc]. Checksum: 00329322012ABAD2	FASTA	1,551	173,792
	10 20 30 40 50 60 MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC LFSHVDFSGD 70 80 90 100 110 120 GKSSGKDFHQ TQFLIQECAL LITKPNFIST LSYAIDNPLH YQKSLKPAPH LFAQLSKVLK 130 140 150 160 170 180 LSKVQEVIFG LALLNSSSSD LRGFAAQFIK QKLPDLLRSY IDADVSGNQE GGFQDIAIEV 190 200 210 220 230 240 LHLLLSHLLF GQKGAFGVGQ EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL 250 260 270 280 290 300 PDSGGVAKTM MESSLADFMQ EVGYGFCASI EECRNIIVQF GVREVTAAQV ARVLGMMART 310 320 330 340 350 360 HSGLTDGIPL QSISAPGSGI WSDGKDKSDG AQAHTWNVEV LIDVLKELNP SLNFKEVTYE 370 380 390 400 410 420 LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDLIYRPWK HAEGQLSFIQ HSLINPEIFC 430 440 450 460 470 480 FADYPCHTVA TDILKAPPED DNREIATWKS LDLIESLLRL AEVGQYEQVK QLFSFPIKHC 490 500 510 520 530 540 PDMLVLALLQ INTSWHTLRH ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH 550 560 570 580 590 600 AMAEWYMRGE QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW 610 620 630 640 650 660 LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT MLACLQACAG 670 680 690 700 710 720 SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA SSLDAISPVQ IDPLAGMTSL 730 740 750 760 770 780 SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP AKAFPPLSTP NQTTAFSGIG GLSSQLPVGG 790 800 810 820 830 840 LGTGSLTGIG TGALGLPAVN NDPFVQRKLG TSGLNQPTFQ QSKMKPSDLS QVWPEANQHF 850 860 870 880 890 900 SKEIDDEANS YFQRIYNHPP HPTMSVDEVL EMLQRFKDST IKREREVFNC MLRNLFEEYR 910 920 930 940 950 960 FFPQYPDKEL HITACLFGGI IEKGLVTYMA LGLALRYVLE ALRKPFGSKM YYFGIAALDR 970 980 990 1000 1010 1020 FKNRLKDYPQ YCQHLASISH FMQFPHHLQE YIEYGQQSRD PPVKMQGSIT TPGSIALAQA 1030 1040 1050 1060 1070 1080 QAQAQVPAKA PLAGQVSTMV TTSTTTTVAK TVTVTRPTGV SFKKDVPPSI NTTNIDTLLV 1090 1100 1110 1120 1130 1140 ATDQTERIVE PPENIQEKIA FIFNNLSQSN MTQKVEELKE TVKEEFMPWV SQYLVMKRVS 1150 1160 1170 1180 1190 1200 IEPNFHSLYS NFLDTLKNPE FNKMVLNETY RNIKVLLTSD KAAANFSDRS LLKNLGHWLG 1210 1220 1230 1240 1250 1260 MITLAKNKPI LHTDLDVKSL LLEAYVKGQQ ELLYVVPFVA KVLESSIRSV VFRPPNPWTM 1270 1280 1290 1300 1310 1320 AIMNVLAELH QEHDLKLNLK FEIEVLCKNL ALDINELKPG NLLKDKDRLK NLDEQLSAPK 1330 1340 1350 1360 1370 1380 KDVKQPEELP PITTTTTSTT PATNTTCTAT VPPQPQYSYH DINVYSLAGL APHITLNPTI 1390 1400 1410 1420 1430 1440 PLFQAHPQLK QCVRQAIERA VQELVHPVVD RSIKIAMTTC EQIVRKDFAL DSEESRMRIA 1450 1460 1470 1480 1490 1500 AHHMMRNLTA GMAMITCREP LLMSISTNLK NSFASALRVS WLFPWYRYKT YYCLSVIIFF 1510 1520 1530 1540 1550 FVYIWHWALP LILNNHHICL MSSIILDCNS VRQSIMSVCF FFFLLYSQHD V

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 244-2376 (ISOFORM 1). Tissue: Cervix, Fetal kidney and Testis.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 757-2376 (ISOFORM 1), VARIANT ALA-603. Tissue: Choriocarcinoma, Leiomyosarcoma and Testis.
[4]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 537-2376 (ISOFORM 2). Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1964-2374 (ISOFORM 1). Tissue: Adrenal gland.
[7]	"Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits." Albert T.K., Lemaire M., van Berkum N.L., Gentz R., Collart M.A., Timmers H.T.M. Nucleic Acids Res. 28:809-817(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CNOT2; CNOT4 AND CNOT8, TISSUE SPECIFICITY.
[8]	"Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription." Winkler G.S., Mulder K.W., Bardwell V.J., Kalkhoven E., Timmers H.T. EMBO J. 25:3089-3099(2006) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DOMAIN, INTERACTION WITH CNOT2; CNOT3; CNOT8; ESR1 AND RXRA.
[9]	"Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex." Miyasaka T., Morita M., Ito K., Suzuki T., Fukuda H., Takeda S., Inoue J., Semba K., Yamamoto T. Cancer Sci. 99:755-761(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TOB1.
[10]	"Human Ccr4-Not complexes contain variable deadenylase subunits." Lau N.C., Kolkman A., van Schaik F.M., Mulder K.W., Pijnappel W.W., Heck A.J., Timmers H.T. Biochem. J. 422:443-453(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION IN THE CCR4-NOT COMPLEX, COMPOSITION OF THE CCR4-NOT COMPLEX.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[12]	"GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets." Braun J.E., Huntzinger E., Fauser M., Izaurralde E. Mol. Cell 44:120-133(2011) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH TNRC6A; TNRC6B AND TNRC6C.
[13]	"miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT." Fabian M.R., Cieplak M.K., Frank F., Morita M., Green J., Srikumar T., Nagar B., Yamamoto T., Raught B., Duchaine T.F., Sonenberg N. Nat. Struct. Mol. Biol. 18:1211-1217(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH TNRC6C.
[14]	"Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin." Sandler H., Kreth J., Timmers H.T., Stoecklin G. Nucleic Acids Res. 39:4373-4386(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH ZFP36.
[15]	"The role of the CNOT1 subunit of the CCR4-NOT complex in mRNA deadenylation and cell viability." Ito K., Takahashi A., Morita M., Suzuki T., Yamamoto T. Protein Cell 2:755-763(2011) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[16]	"Cnot1, Cnot2, and Cnot3 maintain mouse and human ESC identity and inhibit extraembryonic differentiation." Zheng X., Dumitru R., Lackford B.L., Freudenberg J.M., Singh A.P., Archer T.K., Jothi R., Hu G. Stem Cells 30:910-922(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[17]	"The structural basis for the interaction between the CAF1 nuclease and the NOT1 scaffold of the human CCR4-NOT deadenylase complex." Petit A.P., Wohlbold L., Bawankar P., Huntzinger E., Schmidt S., Izaurralde E., Weichenrieder O. Nucleic Acids Res. 40:11058-11072(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1093-1317 IN COMPLEX WITH CNOT7, INTERACTION WITH CNOT8; CNOT6 AND CNOT6L, MUTAGENESIS OF LYS-1208; HIS-1212 AND LYS-1218.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AL117492 mRNA. Translation: CAB55960.1.
BX537840 mRNA. Translation: CAD97851.1.
CR749237 mRNA. Translation: CAH18093.1. Different initiation.
EF553522 mRNA. Translation: ABQ66268.1.
AC009118 Genomic DNA. No translation available.
AC010287 Genomic DNA. No translation available.
BC000779 mRNA. Translation: AAH00779.2.
BC024317 mRNA. Translation: AAH24317.1.
BC040523 mRNA. Translation: AAH40523.1.
AB023224 mRNA. Translation: BAA76851.2.
AF110778 mRNA. Translation: AAF14861.1. Frameshift.

IPI

IPI00166010.
IPI00410157.
IPI00642900.
IPI00880052.

PIR

T17270.

RefSeq

NP_001252541.1. NM_001265612.1.
NP_057368.3. NM_016284.4.
NP_996882.1. NM_206999.2.

UniGene

Hs.460923.
Hs.731691.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4GMJ	X-ray	2.70	A/C/E	1093-1317	[»]
4GML	X-ray	2.90	A/B/C/D/E/F	1093-1317	[»]

ProteinModelPortal

A5YKK6.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-44954N.

IntAct

A5YKK6. 28 interactions.

MINT

MINT-3084598.

PTM databases

PhosphoSite

A5YKK6.

Proteomic databases

PaxDb

A5YKK6.

PeptideAtlas

A5YKK6.

PRIDE

A5YKK6.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000317147; ENSP00000320949; ENSG00000125107.
ENST00000441024; ENSP00000413113; ENSG00000125107.
ENST00000567188; ENSP00000456649; ENSG00000125107.
ENST00000569240; ENSP00000455635; ENSG00000125107.

GeneID

23019.

KEGG

hsa:23019.

UCSC

uc002enu.4. human.
uc002env.3. human.
uc002enx.3. human.

Organism-specific databases

CTD

23019.

GeneCards

GC16M058553.

H-InvDB

HIX0013093.

HGNC

HGNC:7877. CNOT1.

MIM

604917. gene.

neXtProt

NX_A5YKK6.

PharmGKB

PA26672.

HUGE

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GenAtlas

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Phylogenomic databases

eggNOG

COG5103.

HOVERGEN

HBG060834.

InParanoid

A5YKK6.

KO

K12604.

OMA

YLKARAP.

OrthoDB

EOG495ZQV.

PhylomeDB

A5YKK6.

Enzyme and pathway databases

Reactome

REACT_21257. Metabolism of RNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpress

A5YKK6.

Bgee

A5YKK6.

Genevestigator

A5YKK6.

Family and domain databases

InterPro

IPR007196. CCR4-Not_Not1_C.
IPR024557. CCR4-Not_Not1su_DUF3819.
[Graphical view]

Pfam

PF12842. DUF3819. 1 hit.
PF04054. Not1. 1 hit.
[Graphical view]

ProtoNet

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Other

ChiTaRS

CNOT1. human.

GenomeRNAi

23019.

NextBio

43960.

SOURCE

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Entry information

Entry name

CNOT1_HUMAN

Accession

Primary (citable) accession number: A5YKK6
Secondary accession number(s): Q68DX7 , Q7Z3K2, Q8IWB8, Q8TB53, Q9BVZ6, Q9UFR8, Q9UI27, Q9Y2L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 29, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.