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Protein

CCR4-NOT transcription complex subunit 1

Gene

CNOT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.7 Publications

GO - Molecular functioni

  • armadillo repeat domain binding Source: BHF-UCL
  • estrogen receptor binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • protein complex scaffold Source: BHF-UCL
  • protein domain specific binding Source: BHF-UCL
  • retinoic acid receptor binding Source: UniProtKB

GO - Biological processi

  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
  • gene silencing by miRNA Source: BHF-UCL
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
  • negative regulation of retinoic acid receptor signaling pathway Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • negative regulation of translation Source: BHF-UCL
  • nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
  • positive regulation of cytoplasmic mRNA processing body assembly Source: UniProtKB
  • positive regulation of mRNA catabolic process Source: BHF-UCL
  • positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: UniProtKB
  • positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: UniProtKB
  • regulation of stem cell population maintenance Source: UniProtKB
  • RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

RNA-mediated gene silencing, Transcription, Transcription regulation, Translation regulation

Enzyme and pathway databases

ReactomeiR-HSA-429947. Deadenylation of mRNA.
R-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
CCR4-NOT transcription complex subunit 1
Alternative name(s):
CCR4-associated factor 1
Negative regulator of transcription subunit 1 homolog
Short name:
NOT1H
Short name:
hNOT1
Gene namesi
Name:CNOT1
Synonyms:CDC39, KIAA1007, NOT1
ORF Names:AD-005
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:7877. CNOT1.

Subcellular locationi

GO - Cellular componenti

  • CCR4-NOT complex Source: UniProtKB
  • CCR4-NOT core complex Source: GO_Central
  • cytoplasm Source: HPA
  • cytoplasmic mRNA processing body Source: UniProtKB
  • cytosol Source: Reactome
  • extracellular space Source: UniProtKB
  • intracellular membrane-bounded organelle Source: HPA
  • membrane Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
  • peroxisomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1208K → E: Impairs interaction with CNOT7; when associated with Y-1212 and E-1218. 1 Publication1
Mutagenesisi1209P → Y: Abolishes interaction with CNOT7; when associated with Y-1257. 1
Mutagenesisi1212H → Y: Impairs interaction with CNOT7; when associated with E-1208 and E-1218. 1 Publication1
Mutagenesisi1218K → E: Impairs interaction with CNOT7; when associated with E-1208 and Y-1212. 1 Publication1
Mutagenesisi1251V → R: Abolishes interaction with CNOT7. 1
Mutagenesisi1257P → Y: Abolishes interaction with CNOT7; when associated with Y-1209. 1

Organism-specific databases

DisGeNETi23019.
OpenTargetsiENSG00000125107.
PharmGKBiPA26672.

Polymorphism and mutation databases

BioMutaiCNOT1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003155411 – 2376CCR4-NOT transcription complex subunit 1Add BLAST2376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei318PhosphoserineCombined sources1
Modified residuei1061PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiA5YKK6.
MaxQBiA5YKK6.
PaxDbiA5YKK6.
PRIDEiA5YKK6.

PTM databases

iPTMnetiA5YKK6.
PhosphoSitePlusiA5YKK6.
SwissPalmiA5YKK6.

Expressioni

Tissue specificityi

Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon.1 Publication

Developmental stagei

Expressed in embryonic stem (ES) cells.1 Publication

Gene expression databases

BgeeiENSG00000125107.
ExpressionAtlasiA5YKK6. baseline and differential.
GenevisibleiA5YKK6. HS.

Organism-specific databases

HPAiHPA046577.
HPA049664.

Interactioni

Subunit structurei

Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits. In the complex, interacts directly with CNOT6, CNOT6L, CNOT7 or CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2, TOB1 and ZFP36. Interacts with TNRC6A, TNRC6B or TNRC6C; the interactions are direct.9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CNOT11Q9UKZ14EBI-1222758,EBI-2562014
CNOT2Q9NZN85EBI-1222758,EBI-743033
CNOT3O751752EBI-1222758,EBI-743073
CNOT6Q9ULM63EBI-1222758,EBI-2104530
CNOT6LQ96LI53EBI-1222758,EBI-1046635
CNOT7Q9UIV17EBI-1222758,EBI-2105113
CNOT8Q9UFF96EBI-1222758,EBI-742299
TNRC6AQ8NDV72EBI-1222758,EBI-2269715
TNRC6BQ9UPQ94EBI-1222758,EBI-947158
TNRC6CQ9HCJ06EBI-1222758,EBI-6507625
TOB1P506164EBI-1222758,EBI-723281
Zfp36P228935EBI-1222758,EBI-647803From a different organism.

GO - Molecular functioni

  • armadillo repeat domain binding Source: BHF-UCL
  • estrogen receptor binding Source: UniProtKB
  • protein complex scaffold Source: BHF-UCL
  • protein domain specific binding Source: BHF-UCL
  • retinoic acid receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi116660. 91 interactors.
DIPiDIP-44954N.
IntActiA5YKK6. 77 interactors.
MINTiMINT-3084598.
STRINGi9606.ENSP00000320949.

Structurei

Secondary structure

12376
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni830 – 832Combined sources3
Turni838 – 840Combined sources3
Helixi841 – 856Combined sources16
Helixi866 – 877Combined sources12
Helixi882 – 897Combined sources16
Helixi899 – 904Combined sources6
Helixi907 – 922Combined sources16
Helixi929 – 942Combined sources14
Helixi949 – 961Combined sources13
Helixi962 – 967Combined sources6
Helixi969 – 976Combined sources8
Helixi981 – 983Combined sources3
Helixi986 – 996Combined sources11
Helixi1076 – 1082Combined sources7
Helixi1093 – 1104Combined sources12
Turni1108 – 1110Combined sources3
Helixi1111 – 1121Combined sources11
Helixi1124 – 1126Combined sources3
Helixi1127 – 1137Combined sources11
Turni1138 – 1141Combined sources4
Helixi1143 – 1145Combined sources3
Helixi1146 – 1156Combined sources11
Helixi1159 – 1177Combined sources19
Helixi1181 – 1183Combined sources3
Helixi1186 – 1202Combined sources17
Helixi1204 – 1206Combined sources3
Turni1212 – 1214Combined sources3
Helixi1217 – 1227Combined sources11
Helixi1229 – 1243Combined sources15
Helixi1244 – 1248Combined sources5
Turni1250 – 1252Combined sources3
Helixi1257 – 1271Combined sources15
Helixi1277 – 1289Combined sources13
Helixi1294 – 1296Combined sources3
Helixi1302 – 1304Combined sources3
Helixi1306 – 1310Combined sources5
Helixi1359 – 1361Combined sources3
Helixi1367 – 1369Combined sources3
Helixi1371 – 1373Combined sources3
Helixi1381 – 1385Combined sources5
Helixi1387 – 1392Combined sources6
Helixi1393 – 1427Combined sources35
Turni1428 – 1430Combined sources3
Helixi1434 – 1476Combined sources43
Helixi1482 – 1522Combined sources41
Helixi1524 – 1535Combined sources12
Helixi1543 – 1552Combined sources10
Helixi1555 – 1557Combined sources3
Beta strandi1561 – 1563Combined sources3
Helixi1566 – 1569Combined sources4
Helixi1570 – 1577Combined sources8
Helixi1848 – 1865Combined sources18
Helixi1866 – 1868Combined sources3
Helixi1870 – 1885Combined sources16
Beta strandi1888 – 1891Combined sources4
Helixi1892 – 1915Combined sources24
Helixi1926 – 1948Combined sources23
Beta strandi1950 – 1954Combined sources5
Helixi1957 – 1981Combined sources25
Helixi1982 – 1984Combined sources3
Helixi1988 – 2000Combined sources13
Helixi2006 – 2009Combined sources4
Helixi2012 – 2025Combined sources14
Turni2028 – 2030Combined sources3
Helixi2032 – 2034Combined sources3
Helixi2035 – 2042Combined sources8
Helixi2045 – 2052Combined sources8
Helixi2056 – 2058Combined sources3
Helixi2061 – 2080Combined sources20
Helixi2086 – 2105Combined sources20
Helixi2107 – 2112Combined sources6
Helixi2114 – 2120Combined sources7
Helixi2126 – 2133Combined sources8
Beta strandi2145 – 2147Combined sources3
Helixi2152 – 2154Combined sources3
Helixi2157 – 2159Combined sources3
Helixi2168 – 2171Combined sources4
Helixi2174 – 2186Combined sources13
Helixi2191 – 2200Combined sources10
Beta strandi2204 – 2207Combined sources4
Beta strandi2208 – 2210Combined sources3
Helixi2212 – 2232Combined sources21
Turni2239 – 2241Combined sources3
Beta strandi2242 – 2245Combined sources4
Helixi2246 – 2257Combined sources12
Helixi2260 – 2271Combined sources12
Beta strandi2276 – 2278Combined sources3
Helixi2279 – 2293Combined sources15
Beta strandi2296 – 2298Combined sources3
Helixi2299 – 2312Combined sources14
Beta strandi2313 – 2316Combined sources4
Helixi2320 – 2331Combined sources12
Helixi2337 – 2339Combined sources3
Turni2342 – 2344Combined sources3
Helixi2348 – 2360Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C0DX-ray3.20A1565-2371[»]
4CQOX-ray2.80A/C1833-2361[»]
4CRUX-ray1.65A1356-1607[»]
4CRVX-ray2.05A1356-1607[»]
4CRWX-ray1.75A1093-1317[»]
4CT4X-ray2.30A/C1063-1314[»]
4CT6X-ray2.10A1352-1594[»]
4CT7X-ray1.90A1352-1594[»]
4GMJX-ray2.70A/C/E1093-1317[»]
4GMLX-ray2.90A/B/C/D/E/F1093-1317[»]
4J8SX-ray1.55A800-1004[»]
5ANRX-ray2.10A1063-1314[»]
5FU6X-ray2.90A/D1833-2361[»]
5FU7X-ray3.10A/E1833-2361[»]
ProteinModelPortaliA5YKK6.
SMRiA5YKK6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni800 – 1015Interaction with ZFP36Add BLAST216
Regioni1090 – 1605Interaction with CNOT6, CNOT6L, CNOT7 and CNOT81 PublicationAdd BLAST516

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi153 – 157LXXLL5
Motifi181 – 185LXXLL5
Motifi223 – 227LXXLL5
Motifi570 – 574LXXLL5
Motifi1639 – 1643LXXLL5
Motifi1942 – 1946LXXLL5
Motifi2096 – 2100LXXLL5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1333 – 1350Thr-richAdd BLAST18

Domaini

Contains Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, a motif known to be important for the association with nuclear receptors.1 Publication

Sequence similaritiesi

Belongs to the CNOT1 family.Curated

Phylogenomic databases

eggNOGiKOG1831. Eukaryota.
COG5103. LUCA.
GeneTreeiENSGT00390000014869.
HOVERGENiHBG060834.
InParanoidiA5YKK6.
KOiK12604.
OMAiPNVFAND.
OrthoDBiEOG091G0050.
PhylomeDBiA5YKK6.
TreeFamiTF105630.

Family and domain databases

InterProiIPR007196. CCR4-Not_Not1_C.
IPR024557. CCR4-Not_Not1su_DUF3819.
IPR032191. CNOT1_CAF1_bind.
IPR032194. CNOT1_HEAT.
IPR032193. CNOT1_TTP_bind.
[Graphical view]
PfamiPF16415. CNOT1_CAF1_bind. 1 hit.
PF16418. CNOT1_HEAT. 1 hit.
PF16417. CNOT1_TTP_bind. 1 hit.
PF12842. DUF3819. 1 hit.
PF04054. Not1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: A5YKK6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC
60 70 80 90 100
LFSHVDFSGD GKSSGKDFHQ TQFLIQECAL LITKPNFIST LSYAIDNPLH
110 120 130 140 150
YQKSLKPAPH LFAQLSKVLK LSKVQEVIFG LALLNSSSSD LRGFAAQFIK
160 170 180 190 200
QKLPDLLRSY IDADVSGNQE GGFQDIAIEV LHLLLSHLLF GQKGAFGVGQ
210 220 230 240 250
EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL PDSGGVAKTM
260 270 280 290 300
MESSLADFMQ EVGYGFCASI EECRNIIVQF GVREVTAAQV ARVLGMMART
310 320 330 340 350
HSGLTDGIPL QSISAPGSGI WSDGKDKSDG AQAHTWNVEV LIDVLKELNP
360 370 380 390 400
SLNFKEVTYE LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDLIYRPWK
410 420 430 440 450
HAEGQLSFIQ HSLINPEIFC FADYPCHTVA TDILKAPPED DNREIATWKS
460 470 480 490 500
LDLIESLLRL AEVGQYEQVK QLFSFPIKHC PDMLVLALLQ INTSWHTLRH
510 520 530 540 550
ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH AMAEWYMRGE
560 570 580 590 600
QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW
610 620 630 640 650
LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT
660 670 680 690 700
MLACLQACAG SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA
710 720 730 740 750
SSLDAISPVQ IDPLAGMTSL SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP
760 770 780 790 800
AKAFPPLSTP NQTTAFSGIG GLSSQLPVGG LGTGSLTGIG TGALGLPAVN
810 820 830 840 850
NDPFVQRKLG TSGLNQPTFQ QSKMKPSDLS QVWPEANQHF SKEIDDEANS
860 870 880 890 900
YFQRIYNHPP HPTMSVDEVL EMLQRFKDST IKREREVFNC MLRNLFEEYR
910 920 930 940 950
FFPQYPDKEL HITACLFGGI IEKGLVTYMA LGLALRYVLE ALRKPFGSKM
960 970 980 990 1000
YYFGIAALDR FKNRLKDYPQ YCQHLASISH FMQFPHHLQE YIEYGQQSRD
1010 1020 1030 1040 1050
PPVKMQGSIT TPGSIALAQA QAQAQVPAKA PLAGQVSTMV TTSTTTTVAK
1060 1070 1080 1090 1100
TVTVTRPTGV SFKKDVPPSI NTTNIDTLLV ATDQTERIVE PPENIQEKIA
1110 1120 1130 1140 1150
FIFNNLSQSN MTQKVEELKE TVKEEFMPWV SQYLVMKRVS IEPNFHSLYS
1160 1170 1180 1190 1200
NFLDTLKNPE FNKMVLNETY RNIKVLLTSD KAAANFSDRS LLKNLGHWLG
1210 1220 1230 1240 1250
MITLAKNKPI LHTDLDVKSL LLEAYVKGQQ ELLYVVPFVA KVLESSIRSV
1260 1270 1280 1290 1300
VFRPPNPWTM AIMNVLAELH QEHDLKLNLK FEIEVLCKNL ALDINELKPG
1310 1320 1330 1340 1350
NLLKDKDRLK NLDEQLSAPK KDVKQPEELP PITTTTTSTT PATNTTCTAT
1360 1370 1380 1390 1400
VPPQPQYSYH DINVYSLAGL APHITLNPTI PLFQAHPQLK QCVRQAIERA
1410 1420 1430 1440 1450
VQELVHPVVD RSIKIAMTTC EQIVRKDFAL DSEESRMRIA AHHMMRNLTA
1460 1470 1480 1490 1500
GMAMITCREP LLMSISTNLK NSFASALRTA SPQQREMMDQ AAAQLAQDNC
1510 1520 1530 1540 1550
ELACCFIQKT AVEKAGPEMD KRLATEFELR KHARQEGRRY CDPVVLTYQA
1560 1570 1580 1590 1600
ERMPEQIRLK VGGVDPKQLA VYEEFARNVP GFLPTNDLSQ PTGFLAQPMK
1610 1620 1630 1640 1650
QAWATDDVAQ IYDKCITELE QHLHAIPPTL AMNPQAQALR SLLEVVVLSR
1660 1670 1680 1690 1700
NSRDAIAALG LLQKAVEGLL DATSGADADL LLRYRECHLL VLKALQDGRA
1710 1720 1730 1740 1750
YGSPWCNKQI TRCLIECRDE YKYNVEAVEL LIRNHLVNMQ QYDLHLAQSM
1760 1770 1780 1790 1800
ENGLNYMAVA FAMQLVKILL VDERSVAHVT EADLFHTIET LMRINAHSRG
1810 1820 1830 1840 1850
NAPEGLPQLM EVVRSNYEAM IDRAHGGPNF MMHSGISQAS EYDDPPGLRE
1860 1870 1880 1890 1900
KAEYLLREWV NLYHSAAAGR DSTKAFSAFV GQMHQQGILK TDDLITRFFR
1910 1920 1930 1940 1950
LCTEMCVEIS YRAQAEQQHN PAANPTMIRA KCYHNLDAFV RLIALLVKHS
1960 1970 1980 1990 2000
GEATNTVTKI NLLNKVLGIV VGVLLQDHDV RQSEFQQLPY HRIFIMLLLE
2010 2020 2030 2040 2050
LNAPEHVLET INFQTLTAFC NTFHILRPTK APGFVYAWLE LISHRIFIAR
2060 2070 2080 2090 2100
MLAHTPQQKG WPMYAQLLID LFKYLAPFLR NVELTKPMQI LYKGTLRVLL
2110 2120 2130 2140 2150
VLLHDFPEFL CDYHYGFCDV IPPNCIQLRN LILSAFPRNM RLPDPFTPNL
2160 2170 2180 2190 2200
KVDMLSEINI APRILTNFTG VMPPQFKKDL DSYLKTRSPV TFLSDLRSNL
2210 2220 2230 2240 2250
QVSNEPGNRY NLQLINALVL YVGTQAIAHI HNKGSTPSMS TITHSAHMDI
2260 2270 2280 2290 2300
FQNLAVDLDT EGRYLFLNAI ANQLRYPNSH THYFSCTMLY LFAEANTEAI
2310 2320 2330 2340 2350
QEQITRVLLE RLIVNRPHPW GLLITFIELI KNPAFKFWNH EFVHCAPEIE
2360 2370
KLFQSVAQCC MGQKQAQQVM EGTGAS
Length:2,376
Mass (Da):266,939
Last modified:January 15, 2008 - v2
Checksum:i937A0899537BA615
GO
Isoform 2 (identifier: A5YKK6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     822-827: SKMKPS → T

Show »
Length:2,371
Mass (Da):266,381
Checksum:i23D129C7F9CE775B
GO
Isoform 3 (identifier: A5YKK6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     822-827: SKMKPS → T
     2152-2155: VDML → SLTL
     2156-2376: Missing.

Show »
Length:2,150
Mass (Da):241,260
Checksum:iBBB731593591523C
GO
Isoform 4 (identifier: A5YKK6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1479-1551: TASPQQREMM...DPVVLTYQAE → VSWLFPWYRY...FFLLYSQHDV
     1552-2376: Missing.

Show »
Length:1,551
Mass (Da):173,792
Checksum:i00329322012ABAD2
GO

Sequence cautioni

The sequence AAF14861 differs from that shown. Reason: Frameshift at positions 1969 and 2273.Curated
The sequence CAH18093 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18D → G in CAD97851 (PubMed:17974005).Curated1
Sequence conflicti323D → G in CAD97851 (PubMed:17974005).Curated1
Sequence conflicti922E → G in ABQ66268 (PubMed:17974005).Curated1
Sequence conflicti1063K → R in CAH18093 (PubMed:17974005).Curated1
Sequence conflicti1417M → V in CAD97851 (PubMed:17974005).Curated1
Sequence conflicti1799R → G in CAD97851 (PubMed:17974005).Curated1
Sequence conflicti1936L → P in CAH18093 (PubMed:17974005).Curated1
Sequence conflicti2198 – 2200SNL → RTV in AAF14861 (PubMed:10931946).Curated3
Sequence conflicti2358Q → R in ABQ66268 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038254603D → A.1 PublicationCorresponds to variant rs17854028dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030559822 – 827SKMKPS → T in isoform 2 and isoform 3. 2 Publications6
Alternative sequenceiVSP_0305601479 – 1551TASPQ…TYQAE → VSWLFPWYRYKTYYCLSVII FFFVYIWHWALPLILNNHHI CLMSSIILDCNSVRQSIMSV CFFFFLLYSQHDV in isoform 4. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_0305611552 – 2376Missing in isoform 4. 1 PublicationAdd BLAST825
Alternative sequenceiVSP_0305622152 – 2155VDML → SLTL in isoform 3. 1 Publication4
Alternative sequenceiVSP_0305632156 – 2376Missing in isoform 3. 1 PublicationAdd BLAST221

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117492 mRNA. Translation: CAB55960.1.
BX537840 mRNA. Translation: CAD97851.1.
CR749237 mRNA. Translation: CAH18093.1. Different initiation.
EF553522 mRNA. Translation: ABQ66268.1.
AC009118 Genomic DNA. No translation available.
AC010287 Genomic DNA. No translation available.
BC000779 mRNA. Translation: AAH00779.2.
BC024317 mRNA. Translation: AAH24317.1.
BC040523 mRNA. Translation: AAH40523.1.
AB023224 mRNA. Translation: BAA76851.2.
AF110778 mRNA. Translation: AAF14861.1. Frameshift.
CCDSiCCDS10799.1. [A5YKK6-1]
CCDS45501.1. [A5YKK6-4]
CCDS58468.1. [A5YKK6-2]
PIRiT17270.
RefSeqiNP_001252541.1. NM_001265612.1. [A5YKK6-2]
NP_057368.3. NM_016284.4. [A5YKK6-1]
NP_996882.1. NM_206999.2. [A5YKK6-4]
UniGeneiHs.460923.
Hs.731691.

Genome annotation databases

EnsembliENST00000317147; ENSP00000320949; ENSG00000125107. [A5YKK6-1]
ENST00000441024; ENSP00000413113; ENSG00000125107. [A5YKK6-4]
ENST00000567188; ENSP00000456649; ENSG00000125107. [A5YKK6-3]
ENST00000569240; ENSP00000455635; ENSG00000125107. [A5YKK6-2]
GeneIDi23019.
KEGGihsa:23019.
UCSCiuc002enu.6. human. [A5YKK6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL117492 mRNA. Translation: CAB55960.1.
BX537840 mRNA. Translation: CAD97851.1.
CR749237 mRNA. Translation: CAH18093.1. Different initiation.
EF553522 mRNA. Translation: ABQ66268.1.
AC009118 Genomic DNA. No translation available.
AC010287 Genomic DNA. No translation available.
BC000779 mRNA. Translation: AAH00779.2.
BC024317 mRNA. Translation: AAH24317.1.
BC040523 mRNA. Translation: AAH40523.1.
AB023224 mRNA. Translation: BAA76851.2.
AF110778 mRNA. Translation: AAF14861.1. Frameshift.
CCDSiCCDS10799.1. [A5YKK6-1]
CCDS45501.1. [A5YKK6-4]
CCDS58468.1. [A5YKK6-2]
PIRiT17270.
RefSeqiNP_001252541.1. NM_001265612.1. [A5YKK6-2]
NP_057368.3. NM_016284.4. [A5YKK6-1]
NP_996882.1. NM_206999.2. [A5YKK6-4]
UniGeneiHs.460923.
Hs.731691.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4C0DX-ray3.20A1565-2371[»]
4CQOX-ray2.80A/C1833-2361[»]
4CRUX-ray1.65A1356-1607[»]
4CRVX-ray2.05A1356-1607[»]
4CRWX-ray1.75A1093-1317[»]
4CT4X-ray2.30A/C1063-1314[»]
4CT6X-ray2.10A1352-1594[»]
4CT7X-ray1.90A1352-1594[»]
4GMJX-ray2.70A/C/E1093-1317[»]
4GMLX-ray2.90A/B/C/D/E/F1093-1317[»]
4J8SX-ray1.55A800-1004[»]
5ANRX-ray2.10A1063-1314[»]
5FU6X-ray2.90A/D1833-2361[»]
5FU7X-ray3.10A/E1833-2361[»]
ProteinModelPortaliA5YKK6.
SMRiA5YKK6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116660. 91 interactors.
DIPiDIP-44954N.
IntActiA5YKK6. 77 interactors.
MINTiMINT-3084598.
STRINGi9606.ENSP00000320949.

PTM databases

iPTMnetiA5YKK6.
PhosphoSitePlusiA5YKK6.
SwissPalmiA5YKK6.

Polymorphism and mutation databases

BioMutaiCNOT1.

Proteomic databases

EPDiA5YKK6.
MaxQBiA5YKK6.
PaxDbiA5YKK6.
PRIDEiA5YKK6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317147; ENSP00000320949; ENSG00000125107. [A5YKK6-1]
ENST00000441024; ENSP00000413113; ENSG00000125107. [A5YKK6-4]
ENST00000567188; ENSP00000456649; ENSG00000125107. [A5YKK6-3]
ENST00000569240; ENSP00000455635; ENSG00000125107. [A5YKK6-2]
GeneIDi23019.
KEGGihsa:23019.
UCSCiuc002enu.6. human. [A5YKK6-1]

Organism-specific databases

CTDi23019.
DisGeNETi23019.
GeneCardsiCNOT1.
H-InvDBHIX0013093.
HGNCiHGNC:7877. CNOT1.
HPAiHPA046577.
HPA049664.
MIMi604917. gene.
neXtProtiNX_A5YKK6.
OpenTargetsiENSG00000125107.
PharmGKBiPA26672.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1831. Eukaryota.
COG5103. LUCA.
GeneTreeiENSGT00390000014869.
HOVERGENiHBG060834.
InParanoidiA5YKK6.
KOiK12604.
OMAiPNVFAND.
OrthoDBiEOG091G0050.
PhylomeDBiA5YKK6.
TreeFamiTF105630.

Enzyme and pathway databases

ReactomeiR-HSA-429947. Deadenylation of mRNA.
R-HSA-6804115. TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.

Miscellaneous databases

ChiTaRSiCNOT1. human.
GeneWikiiCNOT1.
GenomeRNAii23019.
PROiA5YKK6.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125107.
ExpressionAtlasiA5YKK6. baseline and differential.
GenevisibleiA5YKK6. HS.

Family and domain databases

InterProiIPR007196. CCR4-Not_Not1_C.
IPR024557. CCR4-Not_Not1su_DUF3819.
IPR032191. CNOT1_CAF1_bind.
IPR032194. CNOT1_HEAT.
IPR032193. CNOT1_TTP_bind.
[Graphical view]
PfamiPF16415. CNOT1_CAF1_bind. 1 hit.
PF16418. CNOT1_HEAT. 1 hit.
PF16417. CNOT1_TTP_bind. 1 hit.
PF12842. DUF3819. 1 hit.
PF04054. Not1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNOT1_HUMAN
AccessioniPrimary (citable) accession number: A5YKK6
Secondary accession number(s): Q68DX7
, Q7Z3K2, Q8IWB8, Q8TB53, Q9BVZ6, Q9UFR8, Q9UI27, Q9Y2L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: November 30, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.