A5YKK6 (CNOT1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
CCR4-NOT transcription complex subunit 1

Alternative name(s):
CCR4-associated factor 1
Negative regulator of transcription subunit 1 homolog
Short name=NOT1H
Short name=hNOT1

Gene names

Name:	CNOT1
Synonyms:	CDC39, KIAA1007, NOT1
ORF Names:	AD-005

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	2376 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Belongs to the CCR4-NOT complex that functions as general transcription regulation complex. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Ref.7 Ref.8
Subunit structure	Subunit of the CCR4-NOT core complex that contains CNOT1, CNOT2, CNOT3, CNOT4 and CNOT8. Interacts in a ligand-dependent fashion with ESR1 and RXRA. Interacts with NANOS2 By similarity. Ref.7 Ref.8
Subcellular location	Cytoplasm › P-body By similarity. Note: NANOS2 promotes its localization to P-body By similarity.
Tissue specificity	Strongly expressed in brain, heart, thymus, spleen, kidney, liver, placenta and lung. Weakly expressed in skeletal muscle and colon. Ref.7
Sequence similarities	Belongs to the CNOT1 family.
Sequence caution	The sequence AAF14861.1 differs from that shown. Reason: Frameshift at positions 1969 and 2273. The sequence CAH18093.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Polymorphism
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	nuclear-transcribed mRNA poly(A) tail shortening Traceable author statement. Source: Reactome regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasmic mRNA processing body Inferred from sequence or structural similarity. Source: UniProtKB cytosol Traceable author statement. Source: Reactome
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TOB1	P50616	3	EBI-1222758,EBI-723281

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: A5YKK6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: A5YKK6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     822-827: SKMKPS → T

Isoform 3 (identifier: A5YKK6-3)

The sequence of this isoform differs from the canonical sequence as follows:
     822-827: SKMKPS → T
     2152-2155: VDML → SLTL
     2156-2376: Missing.

Isoform 4 (identifier: A5YKK6-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1479-1551: TASPQQREMM...DPVVLTYQAE → VSWLFPWYRY...FFLLYSQHDV
     1552-2376: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2376	2376	CCR4-NOT transcription complex subunit 1		PRO_0000315541
Regions
	Compositional bias	1333 – 1350	18	Thr-rich
Amino acid modifications
	Modified residue	1933	1	Phosphotyrosine Ref.9
Natural variations
	Alternative sequence	822 – 827	6	SKMKPS → T in isoform 2 and isoform 3.		VSP_030559
	Alternative sequence	1479 – 1551	73	TASPQ…TYQAE → VSWLFPWYRYKTYYCLSVII FFFVYIWHWALPLILNNHHI CLMSSIILDCNSVRQSIMSV CFFFFLLYSQHDV in isoform 4.		VSP_030560
	Alternative sequence	1552 – 2376	825	Missing in isoform 4.		VSP_030561
	Alternative sequence	2152 – 2155	4	VDML → SLTL in isoform 3.		VSP_030562
	Alternative sequence	2156 – 2376	221	Missing in isoform 3.		VSP_030563
	Natural variant	603	1	D → A. Ref.3 Corresponds to variant rs17854028 [ dbSNP | Ensembl ].		VAR_038254
Experimental info
	Sequence conflict	18	1	D → G in CAD97851. Ref.1
	Sequence conflict	323	1	D → G in CAD97851. Ref.1
	Sequence conflict	922	1	E → G in ABQ66268. Ref.1
	Sequence conflict	1063	1	K → R in CAH18093. Ref.1
	Sequence conflict	1417	1	M → V in CAD97851. Ref.1
	Sequence conflict	1799	1	R → G in CAD97851. Ref.1
	Sequence conflict	1936	1	L → P in CAH18093. Ref.1
	Sequence conflict	2198 – 2200	3	SNL → RTV in AAF14861. Ref.6
	Sequence conflict	2358	1	Q → R in ABQ66268. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 937A0899537BA615	FASTA	2,376	266,939
	10 20 30 40 50 60 MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC LFSHVDFSGD 70 80 90 100 110 120 GKSSGKDFHQ TQFLIQECAL LITKPNFIST LSYAIDNPLH YQKSLKPAPH LFAQLSKVLK 130 140 150 160 170 180 LSKVQEVIFG LALLNSSSSD LRGFAAQFIK QKLPDLLRSY IDADVSGNQE GGFQDIAIEV 190 200 210 220 230 240 LHLLLSHLLF GQKGAFGVGQ EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL 250 260 270 280 290 300 PDSGGVAKTM MESSLADFMQ EVGYGFCASI EECRNIIVQF GVREVTAAQV ARVLGMMART 310 320 330 340 350 360 HSGLTDGIPL QSISAPGSGI WSDGKDKSDG AQAHTWNVEV LIDVLKELNP SLNFKEVTYE 370 380 390 400 410 420 LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDLIYRPWK HAEGQLSFIQ HSLINPEIFC 430 440 450 460 470 480 FADYPCHTVA TDILKAPPED DNREIATWKS LDLIESLLRL AEVGQYEQVK QLFSFPIKHC 490 500 510 520 530 540 PDMLVLALLQ INTSWHTLRH ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH 550 560 570 580 590 600 AMAEWYMRGE QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW 610 620 630 640 650 660 LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT MLACLQACAG 670 680 690 700 710 720 SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA SSLDAISPVQ IDPLAGMTSL 730 740 750 760 770 780 SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP AKAFPPLSTP NQTTAFSGIG GLSSQLPVGG 790 800 810 820 830 840 LGTGSLTGIG TGALGLPAVN NDPFVQRKLG TSGLNQPTFQ QSKMKPSDLS QVWPEANQHF 850 860 870 880 890 900 SKEIDDEANS YFQRIYNHPP HPTMSVDEVL EMLQRFKDST IKREREVFNC MLRNLFEEYR 910 920 930 940 950 960 FFPQYPDKEL HITACLFGGI IEKGLVTYMA LGLALRYVLE ALRKPFGSKM YYFGIAALDR 970 980 990 1000 1010 1020 FKNRLKDYPQ YCQHLASISH FMQFPHHLQE YIEYGQQSRD PPVKMQGSIT TPGSIALAQA 1030 1040 1050 1060 1070 1080 QAQAQVPAKA PLAGQVSTMV TTSTTTTVAK TVTVTRPTGV SFKKDVPPSI NTTNIDTLLV 1090 1100 1110 1120 1130 1140 ATDQTERIVE PPENIQEKIA FIFNNLSQSN MTQKVEELKE TVKEEFMPWV SQYLVMKRVS 1150 1160 1170 1180 1190 1200 IEPNFHSLYS NFLDTLKNPE FNKMVLNETY RNIKVLLTSD KAAANFSDRS LLKNLGHWLG 1210 1220 1230 1240 1250 1260 MITLAKNKPI LHTDLDVKSL LLEAYVKGQQ ELLYVVPFVA KVLESSIRSV VFRPPNPWTM 1270 1280 1290 1300 1310 1320 AIMNVLAELH QEHDLKLNLK FEIEVLCKNL ALDINELKPG NLLKDKDRLK NLDEQLSAPK 1330 1340 1350 1360 1370 1380 KDVKQPEELP PITTTTTSTT PATNTTCTAT VPPQPQYSYH DINVYSLAGL APHITLNPTI 1390 1400 1410 1420 1430 1440 PLFQAHPQLK QCVRQAIERA VQELVHPVVD RSIKIAMTTC EQIVRKDFAL DSEESRMRIA 1450 1460 1470 1480 1490 1500 AHHMMRNLTA GMAMITCREP LLMSISTNLK NSFASALRTA SPQQREMMDQ AAAQLAQDNC 1510 1520 1530 1540 1550 1560 ELACCFIQKT AVEKAGPEMD KRLATEFELR KHARQEGRRY CDPVVLTYQA ERMPEQIRLK 1570 1580 1590 1600 1610 1620 VGGVDPKQLA VYEEFARNVP GFLPTNDLSQ PTGFLAQPMK QAWATDDVAQ IYDKCITELE 1630 1640 1650 1660 1670 1680 QHLHAIPPTL AMNPQAQALR SLLEVVVLSR NSRDAIAALG LLQKAVEGLL DATSGADADL 1690 1700 1710 1720 1730 1740 LLRYRECHLL VLKALQDGRA YGSPWCNKQI TRCLIECRDE YKYNVEAVEL LIRNHLVNMQ 1750 1760 1770 1780 1790 1800 QYDLHLAQSM ENGLNYMAVA FAMQLVKILL VDERSVAHVT EADLFHTIET LMRINAHSRG 1810 1820 1830 1840 1850 1860 NAPEGLPQLM EVVRSNYEAM IDRAHGGPNF MMHSGISQAS EYDDPPGLRE KAEYLLREWV 1870 1880 1890 1900 1910 1920 NLYHSAAAGR DSTKAFSAFV GQMHQQGILK TDDLITRFFR LCTEMCVEIS YRAQAEQQHN 1930 1940 1950 1960 1970 1980 PAANPTMIRA KCYHNLDAFV RLIALLVKHS GEATNTVTKI NLLNKVLGIV VGVLLQDHDV 1990 2000 2010 2020 2030 2040 RQSEFQQLPY HRIFIMLLLE LNAPEHVLET INFQTLTAFC NTFHILRPTK APGFVYAWLE 2050 2060 2070 2080 2090 2100 LISHRIFIAR MLAHTPQQKG WPMYAQLLID LFKYLAPFLR NVELTKPMQI LYKGTLRVLL 2110 2120 2130 2140 2150 2160 VLLHDFPEFL CDYHYGFCDV IPPNCIQLRN LILSAFPRNM RLPDPFTPNL KVDMLSEINI 2170 2180 2190 2200 2210 2220 APRILTNFTG VMPPQFKKDL DSYLKTRSPV TFLSDLRSNL QVSNEPGNRY NLQLINALVL 2230 2240 2250 2260 2270 2280 YVGTQAIAHI HNKGSTPSMS TITHSAHMDI FQNLAVDLDT EGRYLFLNAI ANQLRYPNSH 2290 2300 2310 2320 2330 2340 THYFSCTMLY LFAEANTEAI QEQITRVLLE RLIVNRPHPW GLLITFIELI KNPAFKFWNH 2350 2360 2370 EFVHCAPEIE KLFQSVAQCC MGQKQAQQVM EGTGAS
	Isoform 2 [UniParc]. Checksum: 23D129C7F9CE775B	FASTA	2,371	266,381
	10 20 30 40 50 60 MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC LFSHVDFSGD 70 80 90 100 110 120 GKSSGKDFHQ TQFLIQECAL LITKPNFIST LSYAIDNPLH YQKSLKPAPH LFAQLSKVLK 130 140 150 160 170 180 LSKVQEVIFG LALLNSSSSD LRGFAAQFIK QKLPDLLRSY IDADVSGNQE GGFQDIAIEV 190 200 210 220 230 240 LHLLLSHLLF GQKGAFGVGQ EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL 250 260 270 280 290 300 PDSGGVAKTM MESSLADFMQ EVGYGFCASI EECRNIIVQF GVREVTAAQV ARVLGMMART 310 320 330 340 350 360 HSGLTDGIPL QSISAPGSGI WSDGKDKSDG AQAHTWNVEV LIDVLKELNP SLNFKEVTYE 370 380 390 400 410 420 LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDLIYRPWK HAEGQLSFIQ HSLINPEIFC 430 440 450 460 470 480 FADYPCHTVA TDILKAPPED DNREIATWKS LDLIESLLRL AEVGQYEQVK QLFSFPIKHC 490 500 510 520 530 540 PDMLVLALLQ INTSWHTLRH ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH 550 560 570 580 590 600 AMAEWYMRGE QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW 610 620 630 640 650 660 LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT MLACLQACAG 670 680 690 700 710 720 SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA SSLDAISPVQ IDPLAGMTSL 730 740 750 760 770 780 SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP AKAFPPLSTP NQTTAFSGIG GLSSQLPVGG 790 800 810 820 830 840 LGTGSLTGIG TGALGLPAVN NDPFVQRKLG TSGLNQPTFQ QTDLSQVWPE ANQHFSKEID 850 860 870 880 890 900 DEANSYFQRI YNHPPHPTMS VDEVLEMLQR FKDSTIKRER EVFNCMLRNL FEEYRFFPQY 910 920 930 940 950 960 PDKELHITAC LFGGIIEKGL VTYMALGLAL RYVLEALRKP FGSKMYYFGI AALDRFKNRL 970 980 990 1000 1010 1020 KDYPQYCQHL ASISHFMQFP HHLQEYIEYG QQSRDPPVKM QGSITTPGSI ALAQAQAQAQ 1030 1040 1050 1060 1070 1080 VPAKAPLAGQ VSTMVTTSTT TTVAKTVTVT RPTGVSFKKD VPPSINTTNI DTLLVATDQT 1090 1100 1110 1120 1130 1140 ERIVEPPENI QEKIAFIFNN LSQSNMTQKV EELKETVKEE FMPWVSQYLV MKRVSIEPNF 1150 1160 1170 1180 1190 1200 HSLYSNFLDT LKNPEFNKMV LNETYRNIKV LLTSDKAAAN FSDRSLLKNL GHWLGMITLA 1210 1220 1230 1240 1250 1260 KNKPILHTDL DVKSLLLEAY VKGQQELLYV VPFVAKVLES SIRSVVFRPP NPWTMAIMNV 1270 1280 1290 1300 1310 1320 LAELHQEHDL KLNLKFEIEV LCKNLALDIN ELKPGNLLKD KDRLKNLDEQ LSAPKKDVKQ 1330 1340 1350 1360 1370 1380 PEELPPITTT TTSTTPATNT TCTATVPPQP QYSYHDINVY SLAGLAPHIT LNPTIPLFQA 1390 1400 1410 1420 1430 1440 HPQLKQCVRQ AIERAVQELV HPVVDRSIKI AMTTCEQIVR KDFALDSEES RMRIAAHHMM 1450 1460 1470 1480 1490 1500 RNLTAGMAMI TCREPLLMSI STNLKNSFAS ALRTASPQQR EMMDQAAAQL AQDNCELACC 1510 1520 1530 1540 1550 1560 FIQKTAVEKA GPEMDKRLAT EFELRKHARQ EGRRYCDPVV LTYQAERMPE QIRLKVGGVD 1570 1580 1590 1600 1610 1620 PKQLAVYEEF ARNVPGFLPT NDLSQPTGFL AQPMKQAWAT DDVAQIYDKC ITELEQHLHA 1630 1640 1650 1660 1670 1680 IPPTLAMNPQ AQALRSLLEV VVLSRNSRDA IAALGLLQKA VEGLLDATSG ADADLLLRYR 1690 1700 1710 1720 1730 1740 ECHLLVLKAL QDGRAYGSPW CNKQITRCLI ECRDEYKYNV EAVELLIRNH LVNMQQYDLH 1750 1760 1770 1780 1790 1800 LAQSMENGLN YMAVAFAMQL VKILLVDERS VAHVTEADLF HTIETLMRIN AHSRGNAPEG 1810 1820 1830 1840 1850 1860 LPQLMEVVRS NYEAMIDRAH GGPNFMMHSG ISQASEYDDP PGLREKAEYL LREWVNLYHS 1870 1880 1890 1900 1910 1920 AAAGRDSTKA FSAFVGQMHQ QGILKTDDLI TRFFRLCTEM CVEISYRAQA EQQHNPAANP 1930 1940 1950 1960 1970 1980 TMIRAKCYHN LDAFVRLIAL LVKHSGEATN TVTKINLLNK VLGIVVGVLL QDHDVRQSEF 1990 2000 2010 2020 2030 2040 QQLPYHRIFI MLLLELNAPE HVLETINFQT LTAFCNTFHI LRPTKAPGFV YAWLELISHR 2050 2060 2070 2080 2090 2100 IFIARMLAHT PQQKGWPMYA QLLIDLFKYL APFLRNVELT KPMQILYKGT LRVLLVLLHD 2110 2120 2130 2140 2150 2160 FPEFLCDYHY GFCDVIPPNC IQLRNLILSA FPRNMRLPDP FTPNLKVDML SEINIAPRIL 2170 2180 2190 2200 2210 2220 TNFTGVMPPQ FKKDLDSYLK TRSPVTFLSD LRSNLQVSNE PGNRYNLQLI NALVLYVGTQ 2230 2240 2250 2260 2270 2280 AIAHIHNKGS TPSMSTITHS AHMDIFQNLA VDLDTEGRYL FLNAIANQLR YPNSHTHYFS 2290 2300 2310 2320 2330 2340 CTMLYLFAEA NTEAIQEQIT RVLLERLIVN RPHPWGLLIT FIELIKNPAF KFWNHEFVHC 2350 2360 2370 APEIEKLFQS VAQCCMGQKQ AQQVMEGTGA S
	Isoform 3 [UniParc]. Checksum: BBB731593591523C	FASTA	2,150	241,260
	10 20 30 40 50 60 MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC LFSHVDFSGD 70 80 90 100 110 120 GKSSGKDFHQ TQFLIQECAL LITKPNFIST LSYAIDNPLH YQKSLKPAPH LFAQLSKVLK 130 140 150 160 170 180 LSKVQEVIFG LALLNSSSSD LRGFAAQFIK QKLPDLLRSY IDADVSGNQE GGFQDIAIEV 190 200 210 220 230 240 LHLLLSHLLF GQKGAFGVGQ EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL 250 260 270 280 290 300 PDSGGVAKTM MESSLADFMQ EVGYGFCASI EECRNIIVQF GVREVTAAQV ARVLGMMART 310 320 330 340 350 360 HSGLTDGIPL QSISAPGSGI WSDGKDKSDG AQAHTWNVEV LIDVLKELNP SLNFKEVTYE 370 380 390 400 410 420 LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDLIYRPWK HAEGQLSFIQ HSLINPEIFC 430 440 450 460 470 480 FADYPCHTVA TDILKAPPED DNREIATWKS LDLIESLLRL AEVGQYEQVK QLFSFPIKHC 490 500 510 520 530 540 PDMLVLALLQ INTSWHTLRH ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH 550 560 570 580 590 600 AMAEWYMRGE QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW 610 620 630 640 650 660 LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT MLACLQACAG 670 680 690 700 710 720 SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA SSLDAISPVQ IDPLAGMTSL 730 740 750 760 770 780 SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP AKAFPPLSTP NQTTAFSGIG GLSSQLPVGG 790 800 810 820 830 840 LGTGSLTGIG TGALGLPAVN NDPFVQRKLG TSGLNQPTFQ QTDLSQVWPE ANQHFSKEID 850 860 870 880 890 900 DEANSYFQRI YNHPPHPTMS VDEVLEMLQR FKDSTIKRER EVFNCMLRNL FEEYRFFPQY 910 920 930 940 950 960 PDKELHITAC LFGGIIEKGL VTYMALGLAL RYVLEALRKP FGSKMYYFGI AALDRFKNRL 970 980 990 1000 1010 1020 KDYPQYCQHL ASISHFMQFP HHLQEYIEYG QQSRDPPVKM QGSITTPGSI ALAQAQAQAQ 1030 1040 1050 1060 1070 1080 VPAKAPLAGQ VSTMVTTSTT TTVAKTVTVT RPTGVSFKKD VPPSINTTNI DTLLVATDQT 1090 1100 1110 1120 1130 1140 ERIVEPPENI QEKIAFIFNN LSQSNMTQKV EELKETVKEE FMPWVSQYLV MKRVSIEPNF 1150 1160 1170 1180 1190 1200 HSLYSNFLDT LKNPEFNKMV LNETYRNIKV LLTSDKAAAN FSDRSLLKNL GHWLGMITLA 1210 1220 1230 1240 1250 1260 KNKPILHTDL DVKSLLLEAY VKGQQELLYV VPFVAKVLES SIRSVVFRPP NPWTMAIMNV 1270 1280 1290 1300 1310 1320 LAELHQEHDL KLNLKFEIEV LCKNLALDIN ELKPGNLLKD KDRLKNLDEQ LSAPKKDVKQ 1330 1340 1350 1360 1370 1380 PEELPPITTT TTSTTPATNT TCTATVPPQP QYSYHDINVY SLAGLAPHIT LNPTIPLFQA 1390 1400 1410 1420 1430 1440 HPQLKQCVRQ AIERAVQELV HPVVDRSIKI AMTTCEQIVR KDFALDSEES RMRIAAHHMM 1450 1460 1470 1480 1490 1500 RNLTAGMAMI TCREPLLMSI STNLKNSFAS ALRTASPQQR EMMDQAAAQL AQDNCELACC 1510 1520 1530 1540 1550 1560 FIQKTAVEKA GPEMDKRLAT EFELRKHARQ EGRRYCDPVV LTYQAERMPE QIRLKVGGVD 1570 1580 1590 1600 1610 1620 PKQLAVYEEF ARNVPGFLPT NDLSQPTGFL AQPMKQAWAT DDVAQIYDKC ITELEQHLHA 1630 1640 1650 1660 1670 1680 IPPTLAMNPQ AQALRSLLEV VVLSRNSRDA IAALGLLQKA VEGLLDATSG ADADLLLRYR 1690 1700 1710 1720 1730 1740 ECHLLVLKAL QDGRAYGSPW CNKQITRCLI ECRDEYKYNV EAVELLIRNH LVNMQQYDLH 1750 1760 1770 1780 1790 1800 LAQSMENGLN YMAVAFAMQL VKILLVDERS VAHVTEADLF HTIETLMRIN AHSRGNAPEG 1810 1820 1830 1840 1850 1860 LPQLMEVVRS NYEAMIDRAH GGPNFMMHSG ISQASEYDDP PGLREKAEYL LREWVNLYHS 1870 1880 1890 1900 1910 1920 AAAGRDSTKA FSAFVGQMHQ QGILKTDDLI TRFFRLCTEM CVEISYRAQA EQQHNPAANP 1930 1940 1950 1960 1970 1980 TMIRAKCYHN LDAFVRLIAL LVKHSGEATN TVTKINLLNK VLGIVVGVLL QDHDVRQSEF 1990 2000 2010 2020 2030 2040 QQLPYHRIFI MLLLELNAPE HVLETINFQT LTAFCNTFHI LRPTKAPGFV YAWLELISHR 2050 2060 2070 2080 2090 2100 IFIARMLAHT PQQKGWPMYA QLLIDLFKYL APFLRNVELT KPMQILYKGT LRVLLVLLHD 2110 2120 2130 2140 2150 FPEFLCDYHY GFCDVIPPNC IQLRNLILSA FPRNMRLPDP FTPNLKSLTL
	Isoform 4 [UniParc]. Checksum: 00329322012ABAD2	FASTA	1,551	173,792
	10 20 30 40 50 60 MNLDSLSLAL SQISYLVDNL TKKNYRASQQ EIQHIVNRHG PEADRHLLRC LFSHVDFSGD 70 80 90 100 110 120 GKSSGKDFHQ TQFLIQECAL LITKPNFIST LSYAIDNPLH YQKSLKPAPH LFAQLSKVLK 130 140 150 160 170 180 LSKVQEVIFG LALLNSSSSD LRGFAAQFIK QKLPDLLRSY IDADVSGNQE GGFQDIAIEV 190 200 210 220 230 240 LHLLLSHLLF GQKGAFGVGQ EQIDAFLKTL RRDFPQERCP VVLAPLLYPE KRDILMDRIL 250 260 270 280 290 300 PDSGGVAKTM MESSLADFMQ EVGYGFCASI EECRNIIVQF GVREVTAAQV ARVLGMMART 310 320 330 340 350 360 HSGLTDGIPL QSISAPGSGI WSDGKDKSDG AQAHTWNVEV LIDVLKELNP SLNFKEVTYE 370 380 390 400 410 420 LDHPGFQIRD SKGLHNVVYG IQRGLGMEVF PVDLIYRPWK HAEGQLSFIQ HSLINPEIFC 430 440 450 460 470 480 FADYPCHTVA TDILKAPPED DNREIATWKS LDLIESLLRL AEVGQYEQVK QLFSFPIKHC 490 500 510 520 530 540 PDMLVLALLQ INTSWHTLRH ELISTLMPIF LGNHPNSAII LHYAWHGQGQ SPSIRQLIMH 550 560 570 580 590 600 AMAEWYMRGE QYDQAKLSRI LDVAQDLKAL SMLLNGTPFA FVIDLAALAS RREYLKLDKW 610 620 630 640 650 660 LTDKIREHGE PFIQACMTFL KRRCPSILGG LAPEKDQPKS AQLPPETLAT MLACLQACAG 670 680 690 700 710 720 SVSQELSETI LTMVANCSNV MNKARQPPPG VMPKGRPPSA SSLDAISPVQ IDPLAGMTSL 730 740 750 760 770 780 SIGGSAAPHT QSMQGFPPNL GSAFSTPQSP AKAFPPLSTP NQTTAFSGIG GLSSQLPVGG 790 800 810 820 830 840 LGTGSLTGIG TGALGLPAVN NDPFVQRKLG TSGLNQPTFQ QSKMKPSDLS QVWPEANQHF 850 860 870 880 890 900 SKEIDDEANS YFQRIYNHPP HPTMSVDEVL EMLQRFKDST IKREREVFNC MLRNLFEEYR 910 920 930 940 950 960 FFPQYPDKEL HITACLFGGI IEKGLVTYMA LGLALRYVLE ALRKPFGSKM YYFGIAALDR 970 980 990 1000 1010 1020 FKNRLKDYPQ YCQHLASISH FMQFPHHLQE YIEYGQQSRD PPVKMQGSIT TPGSIALAQA 1030 1040 1050 1060 1070 1080 QAQAQVPAKA PLAGQVSTMV TTSTTTTVAK TVTVTRPTGV SFKKDVPPSI NTTNIDTLLV 1090 1100 1110 1120 1130 1140 ATDQTERIVE PPENIQEKIA FIFNNLSQSN MTQKVEELKE TVKEEFMPWV SQYLVMKRVS 1150 1160 1170 1180 1190 1200 IEPNFHSLYS NFLDTLKNPE FNKMVLNETY RNIKVLLTSD KAAANFSDRS LLKNLGHWLG 1210 1220 1230 1240 1250 1260 MITLAKNKPI LHTDLDVKSL LLEAYVKGQQ ELLYVVPFVA KVLESSIRSV VFRPPNPWTM 1270 1280 1290 1300 1310 1320 AIMNVLAELH QEHDLKLNLK FEIEVLCKNL ALDINELKPG NLLKDKDRLK NLDEQLSAPK 1330 1340 1350 1360 1370 1380 KDVKQPEELP PITTTTTSTT PATNTTCTAT VPPQPQYSYH DINVYSLAGL APHITLNPTI 1390 1400 1410 1420 1430 1440 PLFQAHPQLK QCVRQAIERA VQELVHPVVD RSIKIAMTTC EQIVRKDFAL DSEESRMRIA 1450 1460 1470 1480 1490 1500 AHHMMRNLTA GMAMITCREP LLMSISTNLK NSFASALRVS WLFPWYRYKT YYCLSVIIFF 1510 1520 1530 1540 1550 FVYIWHWALP LILNNHHICL MSSIILDCNS VRQSIMSVCF FFFLLYSQHD V

References

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[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 244-2376 (ISOFORM 1). Tissue: Cervix, Fetal kidney and Testis.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 757-2376 (ISOFORM 1), VARIANT ALA-603. Tissue: Choriocarcinoma, Leiomyosarcoma and Testis.
[4]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 537-2376 (ISOFORM 2). Tissue: Brain.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
[6]	"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning." Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L. Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1964-2374 (ISOFORM 1). Tissue: Adrenal gland.
[7]	"Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits." Albert T.K., Lemaire M., van Berkum N.L., Gentz R., Collart M.A., Timmers H.T.M. Nucleic Acids Res. 28:809-817(2000) [PubMed: 10637334] [Abstract] Cited for: FUNCTION, INTERACTION WITH CNOT2; CNOT3; CNOT4 AND CNOT8, TISSUE SPECIFICITY.
[8]	"Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription." Winkler G.S., Mulder K.W., Bardwell V.J., Kalkhoven E., Timmers H.T. EMBO J. 25:3089-3099(2006) [PubMed: 16778766] [Abstract] Cited for: FUNCTION, INTERACTION WITH CNOT2; CNOT3; CNOT8; ESR1 AND RXRA.
[9]	"Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction." Tang L.-Y., Deng N., Wang L.-S., Dai J., Wang Z.-L., Jiang X.-S., Li S.-J., Li L., Sheng Q.-H., Wu D.-Q., Li L., Zeng R. Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed: 17693683] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1933, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL117492 mRNA. Translation: CAB55960.1. BX537840 mRNA. Translation: CAD97851.1. CR749237 mRNA. Translation: CAH18093.1. Different initiation. EF553522 mRNA. Translation: ABQ66268.1. AC009118 Genomic DNA. No translation available. AC010287 Genomic DNA. No translation available. BC000779 mRNA. Translation: AAH00779.2. BC024317 mRNA. Translation: AAH24317.1. BC040523 mRNA. Translation: AAH40523.1. AB023224 mRNA. Translation: BAA76851.2. AF110778 mRNA. Translation: AAF14861.1. Frameshift.
IPI	IPI00166010. IPI00410157. IPI00642900. IPI00880052.
PIR	T17270.
RefSeq	NP_057368.3. NM_016284.3. NP_996882.1. NM_206999.1.
UniGene	Hs.460923. Hs.725184.
3D structure databases
ProteinModelPortal	A5YKK6.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-44954N.
IntAct	A5YKK6. 14 interactions.
MINT	MINT-2835018.
STRING	A5YKK6.
Proteomic databases
PeptideAtlas	A5YKK6.
PRIDE	A5YKK6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317147; ENSP00000320949; ENSG00000125107.
GeneID	23019.
KEGG	hsa:23019.
UCSC	uc002enu.2. human. uc002env.1. human. uc002enx.1. human.
Organism-specific databases
CTD	23019.
GeneCards	GC16M058553.
HGNC	HGNC:7877. CNOT1.
MIM	604917. gene.
neXtProt	NX_A5YKK6.
PharmGKB	PA26672.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06926.
HOVERGEN	HBG060834.
InParanoid	A5YKK6.
OMA	EAYHKGQ.
OrthoDB	EOG495ZQV.
PhylomeDB	A5YKK6.
Enzyme and pathway databases
Reactome	REACT_111217. Metabolism.
Gene expression databases
Bgee	A5YKK6.
Genevestigator	A5YKK6.
Family and domain databases
InterPro	IPR007196. CCR4-Not_Not1_C. IPR024557. CCR4-Not_Not1su_DUF3819. [Graphical view]
KO	K12604.
Pfam	PF12842. DUF3819. 1 hit. PF04054. Not1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	43960.
SOURCE	Search...

Entry information

Entry name

CNOT1_HUMAN

Accession

Primary (citable) accession number: A5YKK6
Secondary accession number(s): Q68DX7 , Q7Z3K2, Q8IWB8, Q8TB53, Q9BVZ6, Q9UFR8, Q9UI27, Q9Y2L0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	January 25, 2012
This is version 46 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.