A5YBL8 (A5YBL8_HORSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase RuleBase RU000493
EC=5.2.1.8 RuleBase RU000493

Gene names

Name:

PPIB EMBL ABQ82138.1 Ensembl ENSECAP00000014710

Organism

Equus caballus (Horse) [Reference proteome]

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins By similarity. RuleBase RU000493 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity. RuleBase RU004223
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0). SAAS SAAS020892 RuleBase RU000493
Sequence similarities	Contains 1 PPIase cyclophilin-type domain. SAAS SAAS020892 RuleBase RU003420

Ontologies

Keywords
Molecular function	Isomerase Rotamase SAAS SAAS020892 RuleBase RU003420
Technical term	3D-structure PDB 4FRV PDB 4FRU Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5YBL8 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: EAAEC58447EA20BE	FASTA	216	23,808
	10 20 30 40 50 60 MLRFSERNMK VLFAAALIVG SVFFLLLPGP STADEKKKGP KVTVKVYFDL RIGDEDIGRV 70 80 90 100 110 120 VIGLFGKTVP KTVDNFVALA TGEKGFGYKD SKFHRVIKDF MIQGGDFTRG DGTGGKSIYG 130 140 150 160 170 180 ERFPDENFKL KHYGPGWVSM ANAGKDTNGS QFFITTVKTA WLDGKHVVFG KVLEGMEVVR 190 200 210 KVETTKTDGR DKPLKDVTIA DCGKIEVEKP FAIAKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse." Tryon R.C., White S.D., Bannasch D.L. Genomics 90:93-102(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Genome sequence, comparative analysis, and population genetics of the domestic horse." Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T. , Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K. Science 326:865-867(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Thoroughbred Ensembl ENSECAP00000014710.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Thoroughbred Ensembl ENSECAP00000014710.
[4]	"Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse." Boudko S.P., Ishikawa Y., Lerch T.F., Nix J., Chapman M.S., Bachinger H.P. BMC Res. Notes 5:626-626(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) OF 34-216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

EF397503 mRNA. Translation: ABQ82138.1.

RefSeq

NP_001093231.1. NM_001099761.1.

UniGene

Eca.5668.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4FRU	X-ray	1.10	A	34-216	[»]
4FRV	X-ray	1.10	A	34-216	[»]

SMR

A5YBL8. Positions 39-216.

ModBase

Search...

Protein-protein interaction databases

STRING

9796.ENSECAP00000014710.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSECAT00000018057; ENSECAP00000014710; ENSECAG00000017164.

GeneID

100066834.

KEGG

ecb:100066834.

Organism-specific databases

CTD

5479.

Phylogenomic databases

eggNOG

COG0652.

GeneTree

ENSGT00670000097658.

HOGENOM

HOG000065981.

HOVERGEN

HBG001065.

InParanoid

A5YBL8.

KO

K03768.

OMA

CERRMKF.

OrthoDB

EOG43XV4N.

Family and domain databases

InterPro

IPR002130. Cyclophilin-like_PPIase_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
[Graphical view]

Pfam

PF00160. Pro_isomerase. 1 hit.
[Graphical view]

PIRSF

PIRSF001467. Peptidylpro_ismrse. 1 hit.

PRINTS

PR00153. CSAPPISMRASE.

SUPFAM

SSF50891. CSA_PPIase. 1 hit.

PROSITE

PS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

A5YBL8_HORSE

Accession

Primary (citable) accession number: A5YBL8

Entry history

Integrated into UniProtKB/TrEMBL:	July 10, 2007
Last sequence update:	July 10, 2007
Last modified:	May 29, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)