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A5YBL8 (A5YBL8_HORSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptidyl-prolyl cis-trans isomerase RuleBase RU000493

EC=5.2.1.8 RuleBase RU000493
Gene names
Name:PPIB EMBL ABQ82138.1 Ensembl ENSECAP00000014710
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity. RuleBase RU004223

Catalytic activity

Peptidylproline (omega=180) = peptidylproline (omega=0). SAAS SAAS020892 RuleBase RU000493

Sequence similarities

Contains 1 PPIase cyclophilin-type domain. RuleBase RU003420

Contains PPIase cyclophilin-type domain. SAAS SAAS020892

Sequences

Sequence LengthMass (Da)Tools
A5YBL8 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: EAAEC58447EA20BE

FASTA21623,808
        10         20         30         40         50         60 
MLRFSERNMK VLFAAALIVG SVFFLLLPGP STADEKKKGP KVTVKVYFDL RIGDEDIGRV 

        70         80         90        100        110        120 
VIGLFGKTVP KTVDNFVALA TGEKGFGYKD SKFHRVIKDF MIQGGDFTRG DGTGGKSIYG 

       130        140        150        160        170        180 
ERFPDENFKL KHYGPGWVSM ANAGKDTNGS QFFITTVKTA WLDGKHVVFG KVLEGMEVVR 

       190        200        210 
KVETTKTDGR DKPLKDVTIA DCGKIEVEKP FAIAKE 

« Hide

References

« Hide 'large scale' references
[1]"Homozygosity mapping approach identifies a missense mutation in equine cyclophilin B (PPIB) associated with HERDA in the American Quarter Horse."
Tryon R.C., White S.D., Bannasch D.L.
Genomics 90:93-102(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Genome sequence, comparative analysis, and population genetics of the domestic horse."
Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F., Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T. expand/collapse author list , Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.
Science 326:865-867(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Thoroughbred Ensembl ENSECAP00000014710.
[3]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: Thoroughbred Ensembl ENSECAP00000014710.
[4]"Crystal structures of wild-type and mutated cyclophilin B that causes hyperelastosis cutis in the American quarter horse."
Boudko S.P., Ishikawa Y., Lerch T.F., Nix J., Chapman M.S., Bachinger H.P.
BMC Res. Notes 5:626-626(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) OF 34-216.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EF397503 mRNA. Translation: ABQ82138.1.
RefSeqNP_001093231.1. NM_001099761.1.
UniGeneEca.5668.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4FRUX-ray1.10A34-216[»]
4FRVX-ray1.10A34-216[»]
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9796.ENSECAP00000014710.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSECAT00000018057; ENSECAP00000014710; ENSECAG00000017164.
GeneID100066834.
KEGGecb:100066834.

Organism-specific databases

CTD5479.

Phylogenomic databases

eggNOGCOG0652.
GeneTreeENSGT00750000117331.
HOGENOMHOG000065981.
HOVERGENHBG001065.
InParanoidA5YBL8.
KOK03768.
OMAKIQNVPK.
OrthoDBEOG7RFTK4.
TreeFamTF354259.

Family and domain databases

InterProIPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PfamPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSPR00153. CSAPPISMRASE.
PROSITEPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5YBL8_HORSE
AccessionPrimary (citable) accession number: A5YBL8
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)