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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

PPIB

Organism
Equus caballus (Horse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.UniRule annotation

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi54ZincCombined sources1
Metal bindingi90ZincCombined sources1
Metal bindingi121ZincCombined sources1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, RotamasePROSITE-ProRule annotationSAAS annotation
LigandMetal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Short name:
PPIaseUniRule annotation
Gene namesi
Name:PPIBImported
OrganismiEquus caballus (Horse)Imported
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Chromosome 1

Organism-specific databases

VGNCiVGNC:21728 PPIB

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PeptideAtlasiA5YBL8

Expressioni

Gene expression databases

BgeeiENSECAG00000017164

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9796.ENSECAP00000014710

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FRUX-ray1.10A34-216[»]
4FRVX-ray1.10A34-216[»]
SMRiA5YBL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 204PPIase cyclophilin-typeInterPro annotationAdd BLAST158

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0880 Eukaryota
ENOG410Z0G4 LUCA
GeneTreeiENSGT00760000119072
HOGENOMiHOG000065981
HOVERGENiHBG001065
KOiK03768
OMAiEPFAVSK
OrthoDBiEOG091G0BGL
TreeFamiTF354259

Family and domain databases

Gene3Di2.40.100.10, 1 hit
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR024936 Cyclophilin-type_PPIase
IPR020892 Cyclophilin-type_PPIase_CS
IPR002130 Cyclophilin-type_PPIase_dom
PANTHERiPTHR11071 PTHR11071, 1 hit
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
PIRSFiPIRSF001467 Peptidylpro_ismrse, 1 hit
PRINTSiPR00153 CSAPPISMRASE
SUPFAMiSSF50891 SSF50891, 1 hit
PROSITEiView protein in PROSITE
PS00170 CSA_PPIASE_1, 1 hit
PS50072 CSA_PPIASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

A5YBL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFSERNMK VLFAAALIVG SVFFLLLPGP STADEKKKGP KVTVKVYFDL
60 70 80 90 100
RIGDEDIGRV VIGLFGKTVP KTVDNFVALA TGEKGFGYKD SKFHRVIKDF
110 120 130 140 150
MIQGGDFTRG DGTGGKSIYG ERFPDENFKL KHYGPGWVSM ANAGKDTNGS
160 170 180 190 200
QFFITTVKTA WLDGKHVVFG KVLEGMEVVR KVETTKTDGR DKPLKDVTIA
210
DCGKIEVEKP FAIAKE
Length:216
Mass (Da):23,808
Last modified:July 10, 2007 - v1
Checksum:iEAAEC58447EA20BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF397503 mRNA Translation: ABQ82138.1
RefSeqiNP_001093231.1, NM_001099761.1
UniGeneiEca.5668

Genome annotation databases

EnsembliENSECAT00000018057; ENSECAP00000014710; ENSECAG00000017164
GeneIDi100066834
KEGGiecb:100066834

Similar proteinsi

Entry informationi

Entry nameiA5YBL8_HORSE
AccessioniPrimary (citable) accession number: A5YBL8
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health