Reviewed, UniProtKB/Swiss-Prot A5YBJ7 (IOLG_LACCA)

Names and origin

Protein names

Recommended name:
    Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
    EC=1.1.1.18
    EC=1.1.1.n6
Alternative name(s):
    Myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase
      Short name=MI 2-dehydrogenase/DCI 3-dehydrogenase

Gene names

Name:

iolG

Organism

Lactobacillus casei

Taxonomic identifier

1582 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	346 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in the oxidation of myo-inositol (MI) and D-chiro-inositol (DCI) to 2-keto-myo-inositol (2KMI or 2-inosose) and 1-keto-D-chiro-inositol (1KDCI), respectively By similarity.
Catalytic activity	Myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH. HAMAP MF_01671 D-chiro-inositol + NAD+ = 2,3,5/4,6-pentahydroxycyclohexanone + NADH. HAMAP MF_01671
Pathway	Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 1/7. HAMAP MF_01671
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the gfo/idh/mocA family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	inositol catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro inositol 2-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 346	346	Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase HAMAP MF_01671		PRO_0000352572

Sequences

	Sequence		Length	Mass (Da)
	A5YBJ7-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 1FCB85142F4C942A	FASTA	346	37,964
	10 20 30 40 50 60 MVVKVGVIGT GAMGRAHIDR LTNVLTGAEV VAVTDIDHEA AEAAVRDFHL NAKVYPDDTS 70 80 90 100 110 120 LLQDPDIDAV FVVSFGGAHE ATVLKALDTD KFIFTEKPLA TTLEGAKRIV DKELTKSKKV 130 140 150 160 170 180 IQVGFMRRYD QGIRALKEKL DTGIIGAPLV VRASHINPNV ASNYSNEMAI TDTLIHEIDE 190 200 210 220 230 240 MHWLLDDEYT SIQITYPRQS AEVRNEGLHD PQLATLTTKK GTVIQVLVHV TAQYGYEVKL 250 260 270 280 290 300 EVIGETGELQ LPNYGLGPIL RSNANQQTAV EMSWINRFIQ AYNTEVQEFI DQVAKSEPPV 310 320 330 340 GPSAWDGYIA AITAAAANRS QKDQETVLIN VAGTPTFYQN KNAIHA

References

[1]

"Identification of a gene cluster allowing Lactobacillus casei BL23 the utilization of myo-inositol." Yebra M.J., Zuniga M., Beaufils S., Perez-Martinez G., Deutscher J., Monedero V. Appl. Environ. Microbiol. 73:3850-3858(2007) [PubMed: 17449687] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: BL23.

Cross-references

Sequence databases
EMBLGenBankDDBJ	EF382358 Genomic DNA. Translation: ABP57766.1.
RefSeq	YP_001986211.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6406058.
Family and domain databases
HAMAP	MF_01671. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR000683. Oxidoreductase_N. IPR004104. OxRdtase_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01408. GFO_IDH_MocA. 1 hit. PF02894. GFO_IDH_MocA_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

IOLG_LACCA

Accession

Primary (citable) accession number: A5YBJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 14, 2008
Last sequence update:	July 10, 2007
Last modified:	September 1, 2009
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)