Skip Header

 
Contribute Send feedback
Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot A5YBJ3 (IOLA_LACCA)

Last modified June 16, 2009. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein namesRecommended name:
    Methylmalonate semialdehyde dehydrogenase [acylating]
      Short name=MMSA dehydrogenase
      Short name=MMSDH
      Short name=MSDH
    EC=1.2.1.27
Alternative name(s):
    Malonate semialdehyde dehydrogenase [acetylating]
      Short name=MSA dehydrogenase
    EC=1.2.1.18
Gene names
Name: iolA
OrganismLactobacillus casei
Taxonomic identifier1582 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Hide | Top

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

Hide | Top

General annotation (Comments)

Function

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity.

Catalytic activity

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H. HAMAP MF_01670

2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH. HAMAP MF_01670

Pathway

Polyol metabolism; myo-inositol degradation into acetyl-CoA; acetyl-CoA from myo-inositol: step 7/7. HAMAP MF_01670

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the aldehyde dehydrogenase family. IolA subfamily.

Hide | Top

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Methylmalonate semialdehyde dehydrogenase [acylating] HAMAP MF_01670
PRO_0000352344

Regions

Nucleotide binding180 – 1845NAD By similarity

Sites

Active site2881Nucleophile By similarity
Binding site3871NAD By similarity

Hide | Top

Sequences

Sequence LengthMass (Da)Tools
A5YBJ3-1 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 276BA314BDA26D8F

FASTA49253,716
        10         20         30         40         50         60 
MDTTKQNVKT LKNFINGKWV DAKTETFENV YNPATGDVLA RVPHSTSEDV ADAVTAAKEA 

        70         80         90        100        110        120 
FKIWQKVSIP KRAKILFKYQ QLLVEHQEEL GRIVTEENGK SLDEAVAEVG RGIENVEFAA 

       130        140        150        160        170        180 
GVPTLMMGDS LSSVATDVEA TNYRYPIGVV GGITPFNFPM MVPCWMFPMA VATGNTFILK 

       190        200        210        220        230        240 
PSEKTPLTSQ RLVELFQEAG LPDGVLNIVN GAVDVVNGIL DHPDIKAISF VGSERVGEYV 

       250        260        270        280        290        300 
YKRGSDHLKR VQALTGAKNH TIVLADADLD AAVKGIISSS FGSAGERCMA TSVLVLQDEI 

       310        320        330        340        350        360 
ADKFMAKFTQ AAKDIKIGNG LDKGVFLGPV IRKENQERTL NYIQTGVKEG AKLVLDGSAE 

       370        380        390        400        410        420 
AKKHDGYFVG PTIFEDVKTD MTIWHDEMFA PVLSVIRAKD LPQAVAIANT SELANGACLF 

       430        440        450        460        470        480 
TDSAASIRYF RENIDAGMLG INLGVPAPIA VFPFSGWKHS FFGTLHANGK DSVDFYTHKK 

       490 
VVTARYDQRR FK

« Hide

Hide | Top

References

[1]"Identification of a gene cluster allowing Lactobacillus casei BL23 the utilization of myo-inositol."
Yebra M.J., Zuniga M., Beaufils S., Perez-Martinez G., Deutscher J., Monedero V.
Appl. Environ. Microbiol. 73:3850-3858(2007) [PubMed: 17449687] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: BL23.

Hide | Top

Cross-references

Sequence databases

EF382358 Genomic DNA. Translation: ABP57762.1.

3D structure databases

ModBaseSearch...

Family and domain databases

HAMAPMF_01670.
[Tree]
InterProIPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
IPR010061. MeMal-semiAld_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PTHR11699:SF27. MMSDH. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
TIGRFAMsTIGR01722. MMSDH. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. False negative.
[Graphical view]
ProtoNetSearch...

Hide | Top

Entry information

Entry nameIOLA_LACCA
AccessionPrimary (citable) accession number: A5YBJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: July 10, 2007
Last modified: June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Hide | Top

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents