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Protein
Submitted name:

Neuregulin 1 variant fetal c IV 2

Gene

NRG1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neuregulin 1 variant fetal c IV 2Imported
Gene namesi
Name:NRG1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Proteomic databases

PeptideAtlasiA5YAK8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 10792Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Phylogenomic databases

HOVERGENiHBG053796.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5YAK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGRAGRVG TTALPPRLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF
60 70 80 90 100
KNGNELNRKN KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND
110 120 130 140 150
SASANITIVE SNATSTSTTG TSHLVKCAEK EKTFCVNGGE CFMVKDLSNP
160 170 180 190
SRYLCKGGGA VPEESADHNR HLHRPPCGRH HVFGGLLQNQ ETAEKAA
Length:197
Mass (Da):21,422
Last modified:July 10, 2007 - v1
Checksum:i817A13843DF40CEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF372277 mRNA. Translation: ABQ53543.1.
RefSeqiNP_001309131.1. NM_001322202.1.
UniGeneiHs.453951.
Hs.668810.

Genome annotation databases

GeneIDi3084.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF372277 mRNA. Translation: ABQ53543.1.
RefSeqiNP_001309131.1. NM_001322202.1.
UniGeneiHs.453951.
Hs.668810.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiA5YAK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3084.

Phylogenomic databases

HOVERGENiHBG053796.

Miscellaneous databases

ChiTaRSiNRG1. human.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR018250. NRG1.
[Graphical view]
PANTHERiPTHR11100:SF7. PTHR11100:SF7. 1 hit.
PfamiPF07679. I-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning of a brain-specific, developmentally regulated neuregulin 1 (NRG1) isoform and identification of a functional promoter variant associated with schizophrenia."
    Tan W., Wang Y., Gold B., Chen J., Dean M., Harrison P.J., Weinberger D.R., Law A.J.
    J. Biol. Chem. 282:24343-24351(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiA5YAK8_HUMAN
AccessioniPrimary (citable) accession number: A5YAK8
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 6, 2016
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.