ID   A5YAK6_HUMAN            Unreviewed;       214 AA.
AC   A5YAK6;
DT   10-JUL-2007, integrated into UniProtKB/TrEMBL.
DT   10-JUL-2007, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   SubName: Full=Neuregulin 1 variant fetal a IV 1 {ECO:0000313|EMBL:ABQ53541.1};
GN   Name=NRG1 {ECO:0000313|EMBL:ABQ53541.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:ABQ53541.1};
RN   [1] {ECO:0000313|EMBL:ABQ53541.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain {ECO:0000313|EMBL:ABQ53541.1};
RX   PubMed=17565985; DOI=10.1074/jbc.M702953200;
RA   Tan W., Wang Y., Gold B., Chen J., Dean M., Harrison P.J., Weinberger D.R.,
RA   Law A.J.;
RT   "Molecular cloning of a brain-specific, developmentally regulated
RT   neuregulin 1 (NRG1) isoform and identification of a functional promoter
RT   variant associated with schizophrenia.";
RL   J. Biol. Chem. 282:24343-24351(2007).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
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DR   EMBL; EF372275; ABQ53541.1; -; mRNA.
DR   RefSeq; NP_001309130.1; NM_001322201.1.
DR   AlphaFoldDB; A5YAK6; -.
DR   MaxQB; A5YAK6; -.
DR   PeptideAtlas; A5YAK6; -.
DR   DNASU; 3084; -.
DR   GeneID; 3084; -.
DR   CTD; 3084; -.
DR   OrthoDB; 3025258at2759; -.
DR   BioGRID-ORCS; 3084; 12 hits in 1160 CRISPR screens.
DR   ChiTaRS; NRG1; human.
DR   GenomeRNAi; 3084; -.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR   CDD; cd05895; Ig_Pro_neuregulin-1; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR040180; Neuregulin.
DR   PANTHER; PTHR11100; HEREGULIN-NEUREGULIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR11100:SF7; PRO-NEUREGULIN-1, MEMBRANE-BOUND ISOFORM; 1.
DR   Pfam; PF07679; I-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          16..107
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   214 AA;  23059 MW;  2FE14468A5E76AB0 CRC64;
     MGKGRAGRVG TTALPPQLKE MKSQESAAGS KLVLRCETSS EYSSLRFKWF KNGNELNRKN
     KPQNIKIQKK PGKSELRINK ASLADSGEYM CKVISKLGND SASANITIVE SNEIITGMPA
     STEGAYVSSA TSTSTTGASH LVKCAEKEKT FCVNGGECFM VKDLSNPSRY LCKGGGAVPE
     ESADHNRHLH RPPCGRHHVF GGLLQNQETA EKAA
//