Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Amiloride-sensitive sodium channel gamma-subunit

Gene

SCNN1G

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionIon channel, Sodium channelSAAS annotation
Biological processIon transport, Sodium transport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Submitted name:
Amiloride-sensitive sodium channel gamma-subunitImported
Submitted name:
Nasal epithelial sodium channel gamma subunitImported
Submitted name:
Sodium channel, nonvoltage-gated 1, gamma, isoform CRA_aImported
Gene namesi
Name:SCNN1GImported
ORF Names:hCG_1685795Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000166828.2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei54 – 79HelicalSequence analysisAdd BLAST26
Transmembranei535 – 561HelicalSequence analysisAdd BLAST27

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA307.

Expressioni

Gene expression databases

BgeeiENSG00000166828.
ExpressionAtlasiA5X2V1. baseline and differential.

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. [View classification]SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4294. Eukaryota.
ENOG410ZNFK. LUCA.
HOVERGENiHBG058435.
KOiK04827.
OMAiNWMYCYY.
OrthoDBiEOG091G0KW6.

Family and domain databases

InterProiView protein in InterPro
IPR001873. ENaC.
IPR004724. ENaC_chordates.
IPR020903. ENaC_CS.
PANTHERiPTHR11690. PTHR11690. 1 hit.
PfamiView protein in Pfam
PF00858. ASC. 1 hit.
PRINTSiPR01078. AMINACHANNEL.
TIGRFAMsiTIGR00859. ENaC. 1 hit.
PROSITEiView protein in PROSITE
PS01206. ASC. 1 hit.

Sequencei

Sequence statusi: Complete.

A5X2V1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGEKIKAK IKKNLPVTGP QAPTIKELMR WYCLNTNTHG CRRIVVSRGR
60 70 80 90 100
LRRLLWIGFT LTAVALILWQ CALLVFSFYT VSVSIKVHFR KLDFPAVTIC
110 120 130 140 150
NINPYKYSTV RHLLADLEQE TREALKSLYG FPESRKRREA ESWNSVSEGK
160 170 180 190 200
QPRFSHRIPL LIFDQDEKGK ARDFFTGRKR KVGGSIIHKA SNVMHIESKQ
210 220 230 240 250
VVGFQLCSND TSDCATYTFS SGINAIQEWY KLHYMNIMAQ VPLEKKINMS
260 270 280 290 300
YSAEELLVTC FFDGVSCDAR NFTLFHHPMH GNCYTFNNRE NETILSTSMG
310 320 330 340 350
GSEYGLQVIL YINEEEYNPF LVSSTGAKVI IHRQDEYPFV EDVGTEIETA
360 370 380 390 400
MVTSIGMHLT ESFKLSEPYS QCTEDGSDVP IRNIYNAAYS LQICLHSCFQ
410 420 430 440 450
TKMVEKCGCA QYSQPLPPAA NYCNYQQHPN WMYCYYQLHR AFVQEELGCQ
460 470 480 490 500
SVCKEACSFK EWTLTTSLAQ WPSVVSEKWL LPVLTWDQGR QVNKKLNKTD
510 520 530 540 550
LAKLLIFYKD LNQRSIMESP ANSIEMLLSN FGGQLGLWMS CSVVCVIEII
560 570 580 590 600
EVFFIDFFSI IARRQWQKAK EWWAWKQAPP CPEAPRSPQG QDNPALDIDD
610 620 630 640
DLPTFNSALH LPPALGTQVP GTPPPKYNTL RLERAFSNQL TDTQMLDEL
Length:649
Mass (Da):74,270
Last modified:July 10, 2007 - v1
Checksum:iF67ED45F03A9BF3F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ402524 mRNA. Translation: ABD72220.1.
FJ515832 Genomic DNA. Translation: ACS13725.1.
CH471145 Genomic DNA. Translation: EAW55837.1.
CH471145 Genomic DNA. Translation: EAW55838.1.
RefSeqiNP_001030.2. NM_001039.3.
UniGeneiHs.371727.

Genome annotation databases

GeneIDi6340.
KEGGihsa:6340.

Similar proteinsi

Entry informationi

Entry nameiA5X2V1_HUMAN
AccessioniPrimary (citable) accession number: A5X2V1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: September 27, 2017
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.