Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A5WWB0

- UBP46_DANRE

UniProt

A5WWB0 - UBP46_DANRE

Protein

Ubiquitin carboxyl-terminal hydrolase 46

Gene

usp46

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 2 (07 Jul 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei44 – 441NucleophilePROSITE-ProRule annotation
    Active sitei317 – 3171Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: UniProtKB
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. behavior Source: UniProtKB-KW
    2. protein deubiquitination Source: UniProtKB
    3. regulation of synaptic transmission, GABAergic Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Behavior, Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.052.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 46 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 46
    Ubiquitin thioesterase 46
    Ubiquitin-specific-processing protease 46
    Gene namesi
    Name:usp46
    ORF Names:ch73-16a12.1
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Chromosome 20

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 370370Ubiquitin carboxyl-terminal hydrolase 46PRO_0000378995Add
    BLAST

    Expressioni

    Gene expression databases

    BgeeiA5WWB0.

    Interactioni

    Protein-protein interaction databases

    STRINGi7955.ENSDARP00000066677.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 369335USPAdd
    BLAST

    Sequence similaritiesi

    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5077.
    GeneTreeiENSGT00650000093027.
    HOGENOMiHOG000231498.
    KOiK11842.
    OrthoDBiEOG7RBZ8G.
    PhylomeDBiA5WWB0.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5WWB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL    50
    QALYFCRPFR ENVLAYKVQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK 100
    KFISRLRKEN DLFDNYMQQD AHEFLNYLLN TVADILQEER KQEKQNGRLK 150
    NNGTAIATDT EPEQNKIDPT WVHEIFQGTL TNETRCLNCE TVSSKDEDFL 200
    DLSVDVEQNT SITHCLRDFS NTETLCSEYK YYCEMCCSKQ EAQKRMRVKK 250
    LPMILALHLK RFKYMEQLHR YTKLSYRVVF PLELRLFNTS GDAVNLDRMY 300
    DLVAVVVHCG SGPNRGHYIT IVKSHGFWLL FDDDIVEKID AQAIEEFYGL 350
    TSDISKNSES GYILFYQSRE 370
    Length:370
    Mass (Da):42,905
    Last modified:July 7, 2009 - v2
    Checksum:iE0FAEF5A62DD6FDA
    GO

    Sequence cautioni

    The sequence CAN88313.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT827859 Genomic DNA. Translation: CAN88313.1. Sequence problems.
    RefSeqiNP_001231910.1. NM_001244981.1.
    UniGeneiDr.122663.
    Dr.5972.

    Genome annotation databases

    EnsembliENSDART00000132093; ENSDARP00000116502; ENSDARG00000045343.
    GeneIDi100148916.
    KEGGidre:100148916.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT827859 Genomic DNA. Translation: CAN88313.1 . Sequence problems.
    RefSeqi NP_001231910.1. NM_001244981.1.
    UniGenei Dr.122663.
    Dr.5972.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7955.ENSDARP00000066677.

    Protein family/group databases

    MEROPSi C19.052.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSDART00000132093 ; ENSDARP00000116502 ; ENSDARG00000045343 .
    GeneIDi 100148916.
    KEGGi dre:100148916.

    Organism-specific databases

    CTDi 64854.

    Phylogenomic databases

    eggNOGi COG5077.
    GeneTreei ENSGT00650000093027.
    HOGENOMi HOG000231498.
    KOi K11842.
    OrthoDBi EOG7RBZ8G.
    PhylomeDBi A5WWB0.

    Miscellaneous databases

    NextBioi 20792542.
    PROi A5WWB0.

    Gene expression databases

    Bgeei A5WWB0.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The zebrafish reference genome sequence and its relationship to the human genome."
      Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
      , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
      Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tuebingen.

    Entry informationi

    Entry nameiUBP46_DANRE
    AccessioniPrimary (citable) accession number: A5WWB0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: July 7, 2009
    Last modified: October 1, 2014
    This is version 49 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3