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Protein

Ubiquitin carboxyl-terminal hydrolase 46

Gene

usp46

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Deubiquitinating enzyme that plays a role in behavior, possibly by regulating GABA action (By similarity). Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei44NucleophilePROSITE-ProRule annotation1
Metal bindingi186ZincBy similarity1
Metal bindingi189ZincBy similarity1
Metal bindingi233ZincBy similarity1
Metal bindingi236ZincBy similarity1
Active sitei317Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processBehavior, Ubl conjugation pathway
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiC19.052.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 46 (EC:3.4.19.12By similarity)
Alternative name(s):
Deubiquitinating enzyme 46
Ubiquitin thioesterase 46
Ubiquitin-specific-processing protease 46
Gene namesi
Name:usp46
ORF Names:ch73-16a12.1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789951 – 370Ubiquitin carboxyl-terminal hydrolase 46Add BLAST370

Proteomic databases

PaxDbiA5WWB0.

Expressioni

Gene expression databases

BgeeiENSDARG00000045343.

Interactioni

Subunit structurei

Interacts with WDR48.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000066677.

Structurei

3D structure databases

SMRiA5WWB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 369USPAdd BLAST335

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1864. Eukaryota.
ENOG410XQ81. LUCA.
GeneTreeiENSGT00880000137875.
HOGENOMiHOG000231498.
InParanoidiA5WWB0.
KOiK11842.
OMAiSYKAQQK.
OrthoDBiEOG091G0FC5.
PhylomeDBiA5WWB0.

Family and domain databases

InterProiView protein in InterPro
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
PfamiView protein in Pfam
PF00443. UCH. 1 hit.
PROSITEiView protein in PROSITE
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.

Sequencei

Sequence statusi: Complete.

A5WWB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVRNIASIC NMGTNASALE KDIGPEQFPI NEHYFGLVNF GNTCYCNSVL
60 70 80 90 100
QALYFCRPFR ENVLAYKVQQ KKKENLLTCL ADLFHSIATQ KKKVGVIPPK
110 120 130 140 150
KFISRLRKEN DLFDNYMQQD AHEFLNYLLN TVADILQEER KQEKQNGRLK
160 170 180 190 200
NNGTAIATDT EPEQNKIDPT WVHEIFQGTL TNETRCLNCE TVSSKDEDFL
210 220 230 240 250
DLSVDVEQNT SITHCLRDFS NTETLCSEYK YYCEMCCSKQ EAQKRMRVKK
260 270 280 290 300
LPMILALHLK RFKYMEQLHR YTKLSYRVVF PLELRLFNTS GDAVNLDRMY
310 320 330 340 350
DLVAVVVHCG SGPNRGHYIT IVKSHGFWLL FDDDIVEKID AQAIEEFYGL
360 370
TSDISKNSES GYILFYQSRE
Length:370
Mass (Da):42,905
Last modified:July 7, 2009 - v2
Checksum:iE0FAEF5A62DD6FDA
GO

Sequence cautioni

The sequence CAN88313 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT827859 Genomic DNA. Translation: CAN88313.1. Sequence problems.
RefSeqiNP_001231910.1. NM_001244981.1.
UniGeneiDr.122663.

Genome annotation databases

EnsembliENSDART00000132093; ENSDARP00000116502; ENSDARG00000045343.
GeneIDi100148916.
KEGGidre:100148916.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiUBP46_DANRE
AccessioniPrimary (citable) accession number: A5WWB0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 7, 2009
Last modified: June 7, 2017
This is version 65 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families