Skip Header

Contribute Send feedback
Read comments (?) or add your own

A5WTG9 (A5WTG9_MYCTF) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Aspartate 1-decarboxylase HAMAP MF_00446
EC=4.1.1.11 HAMAP MF_00446
Alternative name(s):
Aspartate alpha-decarboxylase HAMAP MF_00446
Gene names
Name:panD HAMAP MF_00446
Ordered Locus Names:TBFG_13633
OrganismMycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]
Taxonomic identifier336982 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length139 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine By similarity. HAMAP MF_00446 SAAS SAAS003190

Catalytic activity

L-aspartate = beta-alanine + CO2. HAMAP MF_00446 SAAS SAAS003190

Cofactor

Pyruvoyl group By similarity. PIRSR PIRSR006246-1 HAMAP MF_00446 SAAS SAAS003190

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1. HAMAP MF_00446 SAAS SAAS003190

Subunit structure

Heterooctamer of four alpha and four beta subunits By similarity. HAMAP MF_00446 SAAS SAAS003190

Subcellular location

Cytoplasm By similarity HAMAP MF_00446 SAAS SAAS003190.

Post-translational modification

Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus By similarity. PIRSR PIRSR006246-3 HAMAP MF_00446

Sequence similarities

Belongs to the PanD family. HAMAP MF_00446

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region73 – 753Substrate binding By similarity PIRSR PIRSR006246-2 HAMAP MF_00446

Sites

Active site251Schiff-base intermediate with substrate; via pyruvic acid By similarity PIRSR PIRSR006246-1 HAMAP MF_00446
Active site581Proton donor By similarity PIRSR PIRSR006246-1 HAMAP MF_00446
Binding site571Substrate By similarity PIRSR PIRSR006246-2 HAMAP MF_00446

Amino acid modifications

Modified residue251Pyruvic acid (Ser) By similarity PIRSR PIRSR006246-3 HAMAP MF_00446

Sequences

Sequence LengthMass (Da)Tools
A5WTG9 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: C5BFDC1C996ED9C6

FASTA13914,885
        10         20         30         40         50         60 
MLRTMLKSKI HRATVTCADL HYVGSVTIDA DLMDAADLLE GEQVTIVDID NGARLVTYAI 

        70         80         90        100        110        120 
TGERGSGVIG INGAAAHLVH PGDLVILIAY ATMDDARART YQPRIVFVDA YNKPIDMGHD 

       130 
PAFVPENAGE LLDPRLGVG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000717 Genomic DNA. Translation: ABR07958.1.
RefSeqYP_001289560.1. NC_009565.1.

3D structure databases

ProteinModelPortalA5WTG9.
SMRA5WTG9. Positions 1-113.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5WTG9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5224322.
GenomeReviewsGene locus TBFG_13633 in contig CP000717_GR.
KEGGmtf:TBFG_13633.
PATRIC18138807. VBIMycTub9078_4036.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMALYSKIHR.
ProtClustDBPRK05449.

Family and domain databases

HAMAPMF_00446. PanD.
[Tree]
InterProIPR009010. Asp_de-COase-like_fold.
IPR003190. Asp_decarbox.
[Graphical view]
Gene3DG3DSA:2.40.40.20. Asp_decarboxylase-like_fold. 1 hit.
KOK01579.
PANTHERPTHR21012. Asp_decarbox. 1 hit.
PfamPF02261. Asp_decarbox. 1 hit.
[Graphical view]
PIRSFPIRSF006246. Asp_decarbox. 1 hit.
ProDomPD009294. Asp_decarbox. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF50692. Asp_decarb_fold. 1 hit.
TIGRFAMsTIGR00223. PanD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5WTG9_MYCTF
AccessionPrimary (citable) accession number: A5WTG9
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info