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A5WRQ4 (A5WRQ4_MYCTF) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase HAMAP MF_00435
EC=1.1.1.86 HAMAP MF_00435
Alternative name(s):
Acetohydroxy-acid isomeroreductase HAMAP MF_00435
Alpha-keto-beta-hydroxylacil reductoisomerase HAMAP MF_00435
Gene names
Name:ilvC HAMAP MF_00435
Ordered Locus Names:TBFG_13016
OrganismMycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]
Taxonomic identifier336982 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family. HAMAP MF_00435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1051 By similarity HAMAP MF_00435

Sequences

Sequence LengthMass (Da)Tools
A5WRQ4 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 49669E3EDACE25EC

FASTA33336,090
        10         20         30         40         50         60 
MFYDDDADLS IIQGRKVGVI GYGSQGHAHS LSLRDSGVQV RVGLKQGSRS RPKVEEQGLD 

        70         80         90        100        110        120 
VDTPAEVAKW ADVVMVLAPD TAQAEIFAGD IEPNLKPGDA LFFGHGLNVH FGLIKPPADV 

       130        140        150        160        170        180 
AVAMVAPKGP GHLVRRQFVD GKGVPCLVAV EQDPRGDGLA LALSYAKAIG GTRAGVIKTT 

       190        200        210        220        230        240 
FKDETETDLF GEQTVLCGGT EELVKAGFEV MVEAGYPAEL AYFEVLHELK LIVDLMYEGG 

       250        260        270        280        290        300 
LARMYYSVSD TAEFGGYLSG PRVIDAGTKE RMRDILREIQ DGSFVHKLVA DVEGGNKQLE 

       310        320        330 
ELRRQNAEHP IEVVGKKLRD LMSWVDRPIT ETA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000717 Genomic DNA. Translation: ABR07343.1.
RefSeqYP_001288945.1. NC_009565.1.

3D structure databases

ProteinModelPortalA5WRQ4.
SMRA5WRQ4. Positions 1-325.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5WRQ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5223704.
GenomeReviewsGene locus TBFG_13016 in contig CP000717_GR.
KEGGmtf:TBFG_13016.
PATRIC18137471. VBIMycTub9078_3371.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAEYANGRG.
ProtClustDBPRK05479.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameA5WRQ4_MYCTF
AccessionPrimary (citable) accession number: A5WRQ4
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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