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A5WRM0 (A5WRM0_MYCTF) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate carboxylase PIRNR PIRNR001594
EC=6.4.1.1 PIRNR PIRNR001594
Gene names
Ordered Locus Names:TBFG_12982
OrganismMycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP] EMBL ABR07309.1
Taxonomic identifier336982 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›

Protein attributes

Sequence length1127 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second By similarity. PIRNR PIRNR001594

Catalytic activity

ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate. PIRNR PIRNR001594

Cofactor

Biotin By similarity. PIRNR PIRNR001594

Sequences

Sequence LengthMass (Da)Tools
A5WRM0 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 84B0A4CC1A23CD90

FASTA1,127120,424
        10         20         30         40         50         60 
MFSKVLVANR GEIAIRAFRA AYELGVGTVA VYPYEDRNSQ HRLKADESYQ IGDIGHPVHA 

        70         80         90        100        110        120 
YLSVDEIVAT ARRAGADAIY PGYGFLSENP DLAAACAAAG ISFVGPSAEV LELAGNKSRA 

       130        140        150        160        170        180 
IAAAREAGLP VLMSSAPSAS VDELLSVAAG MPFPLFVKAV AGGGGRGMRR VGDIAALPEA 

       190        200        210        220        230        240 
IEAASREAES AFGDPTVYLE QAVINPRHIE VQILADNLGD VIHLYERDCS VQRRHQKVIE 

       250        260        270        280        290        300 
LAPAPHLDAE LRYKMCVDAV AFARHIGYSC AGTVEFLLDE RGEYVFIEMN PRVQVEHTVT 

       310        320        330        340        350        360 
EEITDVDLVA SQLRIAAGET LEQLGLRQED IAPHGAALQC RITTEDPANG FRPDTGRISA 

       370        380        390        400        410        420 
LRTAGGAGVR LDGSTNLGAE ISPYFDSMLV KLTCRGRDLP TAVSRARRAI AEFRIRGVST 

       430        440        450        460        470        480 
NIPFLQAVLD DPDFRAGRVT TSFIDERPQL LTARASADRG TKILNFLADV TVNNPYGSRP 

       490        500        510        520        530        540 
STIYPDDKLP DLDLRAAPPA GSKQRLVKLG PEGFARWLRE SAAVGVTDTT FRDAHQSLLA 

       550        560        570        580        590        600 
TRVRTSGLSR VAPYLARTMP QLLSVECWGG ATYDVALRFL KEDPWERLAT LRAAMPNICL 

       610        620        630        640        650        660 
QMLLRGRNTV GYTPYPEIVT SAFVQEATAT GIDIFRIFDA LNNIESMRPA IDAVRETGSA 

       670        680        690        700        710        720 
IAEVAMCYTG DLTDPGEQLY TLDYYLKLAE QIVDAGAHVL AIKDMAGLLR PPAAQRLVSA 

       730        740        750        760        770        780 
LRSRFDLPVH LHTHDTPGGQ LASYVAAWHA GADAVDGAAA PLAGTTSQPA LSSIVAAAAH 

       790        800        810        820        830        840 
TEYDTGLSLS AVCALEPYWE ALRKVYAPFE SGLPGPTGRV YHHEIPGGQL SNLRQQAIAL 

       850        860        870        880        890        900 
GLGDRFEEIE EAYAGADRVL GRLVKVTPTS KVVGDLALAL VGAGVSADEF ASDPARFGIP 

       910        920        930        940        950        960 
ESVLGFLRGE LGDPPGGWPE PLRTAALAGR GAARPTAQLA ADDEIALSSV GAKRQATLNR 

       970        980        990       1000       1010       1020 
LLFPSPTKEF NEHREAYGDT SQLSANQFFY GLRQGEEHRV KLERGVELLI GLEAISEPDE 

      1030       1040       1050       1060       1070       1080 
RGMRTVMCIL NGQLRPVLVR DRSIASAVPA AEKADRGNPG HIAAPFAGVV TVGVCVGERV 

      1090       1100       1110       1120 
GAGQTIATIE AMKMEAPITA PVAGTVERVA VSDTAQVEGG DLLVVVS

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000717 Genomic DNA. Translation: ABR07309.1.
RefSeqYP_001288911.1. NC_009565.1.

3D structure databases

ProteinModelPortalA5WRM0.
SMRA5WRM0. Positions 4-1126.
ModBaseSearch...

Protein-protein interaction databases

STRING336982.TBFG_12982.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR07309; ABR07309; TBFG_12982.
GeneID5223668.
KEGGmtf:TBFG_12982.
PATRIC18137389. VBIMycTub9078_3332.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1038.
HOGENOMHOG000282801.
KOK01958.
OMARFLYEDP.
ProtClustDBPRK12999.

Enzyme and pathway databases

BioCycMTUB336982:GH7I-3022-MONOMER.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR001882. Biotin_BS.
IPR011764. Biotin_carboxylation_dom.
IPR005482. Biotin_COase_C.
IPR000089. Biotin_lipoyl.
IPR005481. CarbamoylP_synth_lsu_N.
IPR003379. Carboxylase_cons_dom.
IPR005479. CbamoylP_synth_lsu-like_ATP-bd.
IPR016185. PreATP-grasp_dom.
IPR000891. PYR_CT.
IPR005930. Pyruv_COase.
IPR011054. Rudment_hybrid_motif.
IPR011053. Single_hybrid_motif.
[Graphical view]
PANTHERPTHR18866:SF10. PTHR18866:SF10. 1 hit.
PfamPF02785. Biotin_carb_C. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF00289. CPSase_L_chain. 1 hit.
PF02786. CPSase_L_D2. 1 hit.
PF00682. HMGL-like. 1 hit.
PF02436. PYC_OADA. 1 hit.
[Graphical view]
PIRSFPIRSF001594. Pyruv_carbox. 1 hit.
SMARTSM00878. Biotin_carb_C. 1 hit.
[Graphical view]
SUPFAMSSF51230. Hybrid_motif. 1 hit.
SSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR01235. pyruv_carbox. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS50979. BC. 1 hit.
PS00188. BIOTIN. 1 hit.
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00867. CPSASE_2. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5WRM0_MYCTF
AccessionPrimary (citable) accession number: A5WRM0
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info