A5WRL8 (A5WRL8_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphopantetheine adenylyltransferase HAMAP MF_00151
EC=2.7.7.3 HAMAP MF_00151

Alternative name(s):
Dephospho-CoA pyrophosphorylase HAMAP MF_00151
Pantetheine-phosphate adenylyltransferase HAMAP MF_00151

Gene names

Name:	coaD HAMAP MF_00151
Ordered Locus Names:	TBFG_12980

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity. HAMAP MF_00151
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151
Subunit structure	Homohexamer By similarity. HAMAP MF_00151
Subcellular location	Cytoplasm By similarity HAMAP MF_00151.
Sequence similarities	Belongs to the bacterial CoaD family. HAMAP MF_00151

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis HAMAP MF_00151
Cellular component	Cytoplasm HAMAP MF_00151
Ligand	ATP-binding HAMAP MF_00151 Nucleotide-binding
Molecular function	Nucleotidyltransferase HAMAP MF_00151 EMBL ABR07307.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5WRL8 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: DE9F12E18D0C1721	FASTA	161	17,628
	10 20 30 40 50 60 MTGAVCPGSF DPVTLGHVDI FERAAAQFDE VVVAILVNPA KTGMFDLDER IAMVKESTTH 70 80 90 100 110 120 LPNLRVQVGH GLVVDFVRSC GMTAIVKGLR TGTDFEYELQ MAQMNKHIAG VDTFFVATAP 130 140 150 160 RYSFVSSSLA KEVAMLGGDV SELLPEPVNR RLRDRLNTER T

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR07307.1.
RefSeq	YP_001288909.1. NC_009565.1.
3D structure databases
ProteinModelPortal	A5WRL8.
SMR	A5WRL8. Positions 1-157.
ModBase	Search...
Protein-protein interaction databases
STRING	A5WRL8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5223666.
GenomeReviews	Gene locus TBFG_12980 in contig CP000717_GR.
KEGG	mtf:TBFG_12980.
PATRIC	18137385. VBIMycTub9078_3330.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	AMSDFEY.
ProtClustDB	PRK00168.
Family and domain databases
HAMAP	MF_00151. PPAT_bact. [Tree]
InterPro	IPR004821. Cyt_trans-rel. IPR004820. Cytidylyltransf. IPR001980. LPS_biosynth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K00954.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
PRINTS	PR01020. LPSBIOSNTHSS.
TIGRFAMs	TIGR01510. CoaD_prev_kdtB. 1 hit. TIGR00125. Cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5WRL8_MYCTF

Accession

Primary (citable) accession number: A5WRL8

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)