A5WRA5 (A5WRA5_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Probable malate:quinone oxidoreductase HAMAP MF_00212
EC=1.1.5.4 HAMAP MF_00212

Alternative name(s):
MQO HAMAP MF_00212
Malate dehydrogenase [quinone] HAMAP MF_00212

Gene names

Name:	mqo HAMAP MF_00212
Ordered Locus Names:	TBFG_12867

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-malate + a quinone = oxaloacetate + reduced quinone. HAMAP MF_00212 SAAS SAAS006231
Cofactor	FAD By similarity. HAMAP MF_00212 SAAS SAAS006231
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; oxaloacetate from (S)-malate (quinone route): step 1/1. HAMAP MF_00212 SAAS SAAS006231
Sequence similarities	Belongs to the MQO family. HAMAP MF_00212

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle HAMAP MF_00212 SAAS SAAS006231
Ligand	FAD HAMAP MF_00212 SAAS SAAS006231 Flavoprotein HAMAP MF_00212 SAAS SAAS006231
Molecular function	Oxidoreductase HAMAP MF_00212 SAAS SAAS006231
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: HAMAP
Molecular function	malate dehydrogenase (menaquinone) activity Inferred from electronic annotation. Source: EC malate dehydrogenase (quinone) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5WRA5 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: C3B4C469FF4F285F	FASTA	493	53,595
	10 20 30 40 50 60 MSDLARTDVV LIGAGIMSAT LGVLLRRLEP NWSITLIERL DAVAAESSGP WNNAGTGHSA 70 80 90 100 110 120 LCEMNYTPEM PDGSIDITKA VRVNEQFQVT RQFWAYAAEN GILTDVRSFL NPVPHVSFVH 130 140 150 160 170 180 GSRGVEYLRR RQKALAGNPL FAGTEFIESP DEFARRLPFM AAKRAFSEPV ALNWAADGTD 190 200 210 220 230 240 VDFGALAKQL IGYCVQNGTT ALFGHEVRNL SRQSDGSWTV TMCNRRTGEK RKLNTKFVFV 250 260 270 280 290 300 GAGGDTLPVL QKSGIKEVKG FAGFPIGGRF LRAGNPALTA SHRAKVYGFP APGAPPLGAL 310 320 330 340 350 360 HLDLRFVNGK SWLVFGPYAG WSPKFLKHGQ ISDLPRSIRP DNLLSVLGVG LTERRLLNYL 370 380 390 400 410 420 ISQLRLSEPE RVSALREFAP SAIDSDWELT IAGQRVQVIR RDERNGGVLE FGTTVIGDAD 430 440 450 460 470 480 GSIAGLLGGS PGASTAVAIM LDVLQKCFAN RYQSWLPTLK EMVPSLGVQL SNEPALFDEV 490 WSWSTKALKL GAA

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR07194.1.
RefSeq	YP_001288796.1. NC_009565.1.
3D structure databases
ProteinModelPortal	A5WRA5.
ModBase	Search...
Protein-protein interaction databases
STRING	A5WRA5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5223553.
GenomeReviews	Gene locus TBFG_12867 in contig CP000717_GR.
KEGG	mtf:TBFG_12867.
PATRIC	18137123. VBIMycTub9078_3198.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	KKWVPLM.
ProtClustDB	PRK05257.
Family and domain databases
HAMAP	MF_00212. MQO. [Tree]
InterPro	IPR006231. Malate_quinone_OxRdtase. [Graphical view]
KO	K00116.
PANTHER	PTHR13847:SF14. PTHR13847:SF14. 1 hit.
Pfam	PF06039. Mqo. 1 hit. [Graphical view]
TIGRFAMs	TIGR01320. Mal_quin_oxido. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5WRA5_MYCTF

Accession

Primary (citable) accession number: A5WRA5

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)