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A5WR15 (A5WR15_MYCTF) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thymidylate synthase HAMAP MF_00008
Short name=TS HAMAP MF_00008
Short name=TSase HAMAP MF_00008
EC=2.1.1.45 HAMAP MF_00008
Gene names
Name:thyA HAMAP MF_00008
Ordered Locus Names:TBFG_12777
OrganismMycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]
Taxonomic identifier336982 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length263 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity. HAMAP MF_00008

Catalytic activity

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Pathway

Pyrimidine metabolism; dTTP biosynthesis. HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451

Subunit structure

Homodimer By similarity. HAMAP MF_00008 SAAS SAAS023451

Subcellular location

Cytoplasm By similarity HAMAP MF_00008.

Sequence similarities

Belongs to the thymidylate synthase family. RuleBase RU004150

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily. HAMAP MF_00008

Ontologies

Keywords
   Biological processNucleotide biosynthesis HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451
   Cellular componentCytoplasm HAMAP MF_00008
   Molecular functionMethyltransferase HAMAP MF_00008 RuleBase RU000500 SAAS SAAS023451
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processdTMP biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthymidylate synthase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1461 By similarity HAMAP MF_00008

Sequences

Sequence LengthMass (Da)Tools
A5WR15 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: C324579E3E8BB0F3

FASTA26329,823
        10         20         30         40         50         60 
MTPYEDLLRF VLETGTPKSD RTGTGTRSLF GQQMRYDLSA GFPLLTTKKV HFKSVAYELL 

        70         80         90        100        110        120 
WFLRGDSNIG WLHEHGVTIW DEWASDTGEL GPIYGVQWRS WPAPSGEHID QISAALDLLR 

       130        140        150        160        170        180 
TDPDSRRIIV SAWNVGEIER MALPPCHAFF QFYVADGRLS CQLYQRSADL FLGVPFNIAS 

       190        200        210        220        230        240 
YALLTHMMAA QAGLSVGEFI WAGGDCHIYD NHVEQVRLQL SREPRPYPKL LLADRDSIFE 

       250        260 
YTYEDIVVKN YDPHPAIKAP VAV

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000717 Genomic DNA. Translation: ABR07104.1.
RefSeqYP_001288706.1. NC_009565.1.

3D structure databases

ProteinModelPortalA5WR15.
SMRA5WR15. Positions 1-263.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5WR15.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5223463.
GenomeReviewsGene locus TBFG_12777 in contig CP000717_GR.
KEGGmtf:TBFG_12777.
PATRIC18136921. VBIMycTub9078_3097.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMARMALAPC.
ProtClustDBPRK01827.

Family and domain databases

HAMAPMF_00008. Thymidy_synth_bact.
[Tree]
InterProIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
Gene3DG3DSA:3.30.572.10. Thymidylat_synth_C. 1 hit.
KOK00560.
PANTHERPTHR11549:SF2. Thymidylat_synth_C. 1 hit.
PfamPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSPR00108. THYMDSNTHASE.
SUPFAMSSF55831. Thymidylat_synth_C. 1 hit.
TIGRFAMsTIGR03284. Thym_sym. 2 hits.
PROSITEPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5WR15_MYCTF
AccessionPrimary (citable) accession number: A5WR15
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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