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A5WQT1 (A5WQT1_MYCTF) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase HAMAP MF_00218
Short name=UPD HAMAP MF_00218
Short name=URO-D HAMAP MF_00218
EC=4.1.1.37 HAMAP MF_00218
Gene names
Name:hemE HAMAP MF_00218
Ordered Locus Names:TBFG_12693
OrganismMycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]
Taxonomic identifier336982 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218 SAAS SAAS006361

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218 RuleBase RU000554 SAAS SAAS006361

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen III from 5-aminolevulinate: step 4/4. RuleBase RU000554

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218 SAAS SAAS006361

Subunit structure

Homodimer By similarity. HAMAP MF_00218 SAAS SAAS006361

Subcellular location

Cytoplasm By similarity HAMAP MF_00218 SAAS SAAS006361.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family. HAMAP MF_00218 RuleBase RU004169

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region30 – 345Substrate binding By similarity HAMAP MF_00218

Sites

Binding site791Substrate By similarity HAMAP MF_00218
Binding site1541Substrate By similarity HAMAP MF_00218
Binding site2091Substrate By similarity HAMAP MF_00218
Binding site3361Substrate By similarity HAMAP MF_00218
Site791Transition state stabilizer By similarity HAMAP MF_00218

Sequences

Sequence LengthMass (Da)Tools
A5WQT1 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: F5F09F1680BDC7B3

FASTA35737,606
        10         20         30         40         50         60 
MSTRRDLPQS PYLAAVTGRK PSRVPVWFMR QAGRSLPEYR ALRERYSMLA ACFEPDVACE 

        70         80         90        100        110        120 
ITLQPIRRYD VDAAILFSDI VVPLRAAGVD LDIVADVGPV IADPVRTAAD VAAMKPLDPQ 

       130        140        150        160        170        180 
AIQPVLVAAS LLVAELGDVP LIGFAGAPFT LASYLVEGGP SRHHAHVKAM MLAEPASWHA 

       190        200        210        220        230        240 
LMAKLTDLTI AFLVGQIDAG VDAIQVFDSW AGALSPIDYR QYVLPHSARV FAALGEHGVP 

       250        260        270        280        290        300 
MTHFGVGTAE LLGAMSEAVT AGERPGRGAV VGVDWRTPLT DAAARVVPGT ALQGNLDPAV 

       310        320        330        340        350 
VLAGWPAVER AARAVVDDGR RAVDAGAAGH IFNLGHGVLP ESDPAVLADL VSLVHSL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000717 Genomic DNA. Translation: ABR07020.1.
RefSeqYP_001288622.1. NC_009565.1.

3D structure databases

ProteinModelPortalA5WQT1.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5WQT1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5223379.
GenomeReviewsGene locus TBFG_12693 in contig CP000717_GR.
KEGGmtf:TBFG_12693.
PATRIC18136733. VBIMycTub9078_3003.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAPRIHFGV.
ProtClustDBPRK00115.

Family and domain databases

HAMAPMF_00218. URO_D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5WQT1_MYCTF
AccessionPrimary (citable) accession number: A5WQT1
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info