A5WQ45 (A5WQ45_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alkyl hydroperoxide reductase AhpD HAMAP MF_01676
EC=1.11.1.15 HAMAP MF_01676

Alternative name(s):
Alkylhydroperoxidase AhpD HAMAP MF_01676

Gene names

Name:	ahpD HAMAP MF_01676
Ordered Locus Names:	TBFG_12457

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	177 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity By similarity. HAMAP MF_01676 SAAS SAAS004674
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676 SAAS SAAS004674
Subunit structure	Homotrimer By similarity. HAMAP MF_01676
Sequence similarities	Belongs to the AhpD family. HAMAP MF_01676

Ontologies

Keywords
Domain	Redox-active center HAMAP MF_01676 SAAS SAAS004674
Molecular function	Antioxidant HAMAP MF_01676 SAAS SAAS004674 Oxidoreductase Peroxidase HAMAP MF_01676 SAAS SAAS004674
PTM	Disulfide bond HAMAP MF_01676 SAAS SAAS004674
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	130	1	Proton donor By similarity HAMAP MF_01676
	Active site	133	1	Cysteine sulfenic acid (-SOH) intermediate By similarity HAMAP MF_01676
Amino acid modifications
	Disulfide bond	130 ↔ 133		Alternate By similarity HAMAP MF_01676
	Disulfide bond	133		Interchain (with AhpC); in linked form By similarity HAMAP MF_01676

Sequences

	Sequence		Length	Mass (Da)
	A5WQ45 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: B7DD28AA9BD9B24C	FASTA	177	18,781
	10 20 30 40 50 60 MSIEKLKAAL PEYAKDIKLN LSSITRSSVL DQEQLWGTLL ASAAATRNPQ VLADIGAEAT 70 80 90 100 110 120 DHLSAAARHA ALGAAAIMGM NNVFYRGRGF LEGRYDDLRP GLRMNIIANP GIPKANFELW 130 140 150 160 170 SFAVSAINGC SHCLVAHEHT LRTVGVDREA IFEALKAAAI VSGVAQALAT IEALSPS

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR06784.1.
RefSeq	YP_001288386.1. NC_009565.1.
3D structure databases
ProteinModelPortal	A5WQ45.
SMR	A5WQ45. Positions 2-175.
ModBase	Search...
Protein-protein interaction databases
STRING	A5WQ45.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5223134.
GenomeReviews	Gene locus TBFG_12457 in contig CP000717_GR.
KEGG	mtf:TBFG_12457.
PATRIC	18136185. VBIMycTub9078_2738.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	RAGLRMN.
ProtClustDB	CLSK791846.
Family and domain databases
HAMAP	MF_01676. AhpD. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
KO	K04756.
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. AhpD. 1 hit. TIGR00778. AhpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5WQ45_MYCTF

Accession

Primary (citable) accession number: A5WQ45

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)