A5WQ43 (A5WQ43_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Gamma-glutamyl phosphate reductase HAMAP MF_00412
Short name=GPR HAMAP MF_00412
EC=1.2.1.41 HAMAP MF_00412

Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP MF_00412

Gene names

Name:	proA HAMAP MF_00412
Ordered Locus Names:	TBFG_12455

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	415 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP MF_00412 SAAS SAAS020593
Catalytic activity	L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP MF_00412 SAAS SAAS020593
Pathway	Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP MF_00412 SAAS SAAS020593
Subcellular location	Cytoplasm By similarity HAMAP MF_00412 SAAS SAAS020593.
Sequence similarities	Belongs to the gamma-glutamyl phosphate reductase family. HAMAP MF_00412

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Proline biosynthesis HAMAP MF_00412 SAAS SAAS020593
Cellular component	Cytoplasm HAMAP MF_00412 SAAS SAAS020593
Ligand	NADP HAMAP MF_00412 SAAS SAAS020593
Molecular function	Oxidoreductase HAMAP MF_00412 SAAS SAAS020593
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proline biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro glutamate-5-semialdehyde dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5WQ43 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 071C9872F8C9A8AC	FASTA	415	43,745
	10 20 30 40 50 60 MTVPAPSQLD LRQEVHDAAR RARVAARRLA SLPTTVKDRA LHAAADELLA HRDQILAANA 70 80 90 100 110 120 EDLNAAREAD TPAAMLDRLS LNPQRVDGIA AGLRQVAGLR DPVGEVLRGY TLPNGLQLRQ 130 140 150 160 170 180 QRVPLGVVGM IYEGRPNVTV DAFGLTLKSG NAALLRGSSS AAKSNEALVA VLRTALVGLE 190 200 210 220 230 240 LPADAVQLLS AADRATVTHL IQARGLVDVV IPRGGAGLIE AVVRDAQVPT IETGVGNCHV 250 260 270 280 290 300 YVHQAADLDV AERILLNSKT RRPSVCNAAE TLLVDAAIAE TALPRLLAAL QHAGVTVHLD 310 320 330 340 350 360 PDEADLRREY LSLDIAVAVV DGVDAAIAHI NEYGTGHTEA IVTTNLDAAQ RFTEQIDAAA 370 380 390 400 410 VMVNASTAFT DGEQFGFGAE IGISTQKLHA RGPMGLPELT STKWIAWGAG HTRPA

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR06782.1.
RefSeq	YP_001288384.1. NC_009565.1.
3D structure databases
ProteinModelPortal	A5WQ43.
ModBase	Search...
Protein-protein interaction databases
STRING	A5WQ43.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5223132.
GenomeReviews	Gene locus TBFG_12455 in contig CP000717_GR.
KEGG	mtf:TBFG_12455.
PATRIC	18136177. VBIMycTub9078_2734.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	QYPAACN.
ProtClustDB	PRK00197.
Family and domain databases
HAMAP	MF_00412. ProA. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR000965. G-glutamylP_reductase. IPR020593. G-glutamylP_reductase_CS. IPR012134. Glu-5-SA_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 2 hits.
KO	K00147.
PANTHER	PTHR11063:SF1. GSA_DH. 1 hit.
Pfam	PF00171. Aldedh. 2 hits. [Graphical view]
PIRSF	PIRSF000151. GPR. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR00407. ProA. 1 hit.
PROSITE	PS01223. PROA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5WQ43_MYCTF

Accession

Primary (citable) accession number: A5WQ43

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)