A5WMX4 (A5WMX4_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150
Short name=AGPR HAMAP MF_00150
EC=1.2.1.38 HAMAP MF_00150

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase HAMAP MF_00150

Gene names

Name:	argC HAMAP MF_00150
Ordered Locus Names:	TBFG_11670

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150 SAAS SAAS023013
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate. RuleBase RU004258 Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150 SAAS SAAS023013
Subcellular location	Cytoplasm By similarity HAMAP MF_00150 SAAS SAAS023013.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. HAMAP MF_00150

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis HAMAP MF_00150 SAAS SAAS023013
Cellular component	Cytoplasm HAMAP MF_00150 SAAS SAAS023013
Ligand	NADP HAMAP MF_00150 SAAS SAAS023013
Molecular function	Oxidoreductase HAMAP MF_00150 SAAS SAAS023013
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	158	1	By similarity HAMAP MF_00150

Sequences

	Sequence		Length	Mass (Da)
	A5WMX4 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: E7E36B6FC1BAD5CC	FASTA	352	36,304
	10 20 30 40 50 60 MQNRQVANAT KVAVAGASGY AGGEILRLLL GHPAYADGRL RIGALTAATS AGSTLGEHHP 70 80 90 100 110 120 HLTPLAHRVV EPTEAAVLGG HDAVFLALPH GHSAVLAQQL SPETLIIDCG ADFRLTDAAV 130 140 150 160 170 180 WERFYGSSHA GSWPYGLPEL PGARDQLRGT RRIAVPGCYP TAALLALFPA LAADLIEPAV 190 200 210 220 230 240 TVVAVSGTSG AGRAATTDLL GAEVIGSARA YNIAGVHRHT PEIAQGLRAV TDRDVSVSFT 250 260 270 280 290 300 PVLIPASRGI LATCTARTRS PLSQLRAAYE KAYHAEPFIY LMPEGQLPRT GAVIGSNAAH 310 320 330 340 350 IAVAVDEDAQ TFVAIAAIDN LVKGTAGAAV QSMNLALGWP ETDGLSVVGV AP

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR06013.1.
RefSeq	YP_001287615.1. NC_009565.1.
3D structure databases
ProteinModelPortal	A5WMX4.
SMR	A5WMX4. Positions 6-352.
ModBase	Search...
Protein-protein interaction databases
STRING	A5WMX4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5222350.
GenomeReviews	Gene locus TBFG_11670 in contig CP000717_GR.
KEGG	mtf:TBFG_11670.
PATRIC	18134353. VBIMycTub9078_1829.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VCRIAVH.
ProtClustDB	PRK00436.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5WMX4_MYCTF

Accession

Primary (citable) accession number: A5WMX4

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)