A5WM24 (A5WM24_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Ribonuclease PH HAMAP MF_00564
Short name=RNase PH HAMAP MF_00564
EC=2.7.7.56 HAMAP MF_00564

Alternative name(s):
tRNA nucleotidyltransferase HAMAP MF_00564

Gene names

Name:	rph HAMAP MF_00564
Ordered Locus Names:	TBFG_11370

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates By similarity. HAMAP MF_00564 SAAS SAAS018336
Catalytic activity	tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate. HAMAP MF_00564 SAAS SAAS018336
Sequence similarities	Belongs to the RNase PH family. HAMAP MF_00564

Ontologies

Keywords
Biological process	tRNA processing HAMAP MF_00564 SAAS SAAS018336
Molecular function	Nucleotidyltransferase HAMAP MF_00564 SAAS SAAS018336 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tRNA processing Inferred from electronic annotation. Source: HAMAP
Molecular function	tRNA binding Inferred from electronic annotation. Source: HAMAP tRNA nucleotidyltransferase activity Inferred from electronic annotation. Source: HAMAP tRNA-specific ribonuclease activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A5WM24 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: D8461B3089929F9F	FASTA	259	27,351
	10 20 30 40 50 60 MSKREDGRLD HELRPVIITR GFTENPAGSV LIEFGHTKVL CTASVTEGVP RWRKATGLGW 70 80 90 100 110 120 LTAEYAMLPS ATHSRSDRES VRGRLSGRTQ EISRLIGRSL RACIDLAALG ENTIAIDCDV 130 140 150 160 170 180 LQADGGTRTA AITGAYVALA DAVTYLSAAG KLSDPRPLSC AIAAVSVGVV DGRIRVDLPY 190 200 210 220 230 240 EEDSRAEVDM NVVATDTGTL VEIQGTGEGA TFARSTLDKL LDMALGACDT LFAAQRDALA 250 LPYPGVLPQG PPPPKAFGT

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR05713.1.
RefSeq	YP_001287315.1. NC_009565.1.
3D structure databases
ProteinModelPortal	A5WM24.
SMR	A5WM24. Positions 3-248.
ModBase	Search...
Protein-protein interaction databases
STRING	A5WM24.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5222048.
GenomeReviews	Gene locus TBFG_11370 in contig CP000717_GR.
KEGG	mtf:TBFG_11370.
PATRIC	18133696. VBIMycTub9078_1503.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MLPRATG.
ProtClustDB	PRK00173.
Family and domain databases
HAMAP	MF_00564. RNase_PH. [Tree]
InterPro	IPR001247. ExoRNase_PH_dom1. IPR015847. ExoRNase_PH_dom2. IPR020568. Ribosomal_S5_D2-typ_fold. IPR002381. RNase_PH_bac-type. IPR018336. RNase_PH_CS. [Graphical view]
KO	K00989.
Pfam	PF01138. RNase_PH. 1 hit. PF03725. RNase_PH_C. 1 hit. [Graphical view]
SUPFAM	SSF55666. 3_ExoRNase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR01966. RNasePH. 1 hit.
PROSITE	PS01277. RIBONUCLEASE_PH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5WM24_MYCTF

Accession

Primary (citable) accession number: A5WM24

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)