A5WLX7 (A5WLX7_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Homoserine kinase HAMAP MF_00384
Short name=HK HAMAP MF_00384
Short name=HSK HAMAP MF_00384
EC=2.7.1.39 HAMAP MF_00384

Gene names

Name:	thrB HAMAP MF_00384
Ordered Locus Names:	TBFG_11323

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	316 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate By similarity. HAMAP MF_00384
Catalytic activity	ATP + L-homoserine = ADP + O-phospho-L-homoserine. HAMAP MF_00384 SAAS SAAS006203
Pathway	Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5. HAMAP MF_00384 SAAS SAAS006203
Subcellular location	Cytoplasm By similarity HAMAP MF_00384.
Sequence similarities	Belongs to the GHMP kinase family. RuleBase RU004209 Belongs to the GHMP kinase family. Homoserine kinase subfamily. HAMAP MF_00384

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Threonine biosynthesis HAMAP MF_00384 SAAS SAAS006203
Cellular component	Cytoplasm HAMAP MF_00384
Ligand	ATP-binding HAMAP MF_00384 RuleBase RU003563 SAAS SAAS006203 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00384 RuleBase RU003563 SAAS SAAS006203 EMBL ABR05666.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP homoserine kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	97 – 107	11	ATP By similarity HAMAP MF_00384

Sequences

	Sequence		Length	Mass (Da)
	A5WLX7 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: 6C1DA36925F8A427	FASTA	316	32,346
	10 20 30 40 50 60 MVTQALLPSG LVASAVVAAS SANLGPGFDS VGLALSLYDE IIVETTDSGL TVTVDGEGGD 70 80 90 100 110 120 QVPLGPEHLV VRAVQHGLQA AGVSAAGLAV RCRNAIPHSR GLGSSAAAVV GGLAAVNGLV 130 140 150 160 170 180 VQTDSSPSSD AELIQLASEF EGHPDNAAAA VLGGAVVSWT DHSGDRPNYS AVSLRLHPDI 190 200 210 220 230 240 RLFTAIPEQR SSTAETRVLL PAQVSHDDAR FNVSRAALLV VALTERPDLL MAATEDLLHQ 250 260 270 280 290 300 PQRAAAMTAS AEYLRLLRRH NVAAALSGAG PSLIALSTDS ELPTDAVEFG AAKGFAVTEL 310 TVGEAVRWSP TVRVPG

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR05666.1.
RefSeq	YP_001287268.1. NC_009565.1.
3D structure databases
ProteinModelPortal	A5WLX7.
ModBase	Search...
Protein-protein interaction databases
STRING	A5WLX7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5222001.
GenomeReviews	Gene locus TBFG_11323 in contig CP000717_GR.
KEGG	mtf:TBFG_11323.
PATRIC	18133586. VBIMycTub9078_1451.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	DRLHQPY.
ProtClustDB	PRK01212.
Family and domain databases
HAMAP	MF_00384. Homoser_kinase. [Tree]
InterPro	IPR006204. GHMP_kinase. IPR006203. GHMP_knse_ATP-bd_CS. IPR000870. Homoserine_kinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00872.
Pfam	PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000676. Homoser_kin. 1 hit.
PRINTS	PR00958. HOMSERKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00191. ThrB. 1 hit.
PROSITE	PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5WLX7_MYCTF

Accession

Primary (citable) accession number: A5WLX7

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)