Skip Header

Contribute Send feedback
Read comments (?) or add your own

A5WLR9 (A5WLR9_MYCTF) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase HAMAP MF_01517 RuleBase RU000422
EC=1.1.1.37 HAMAP MF_01517 RuleBase RU000422
Gene names
Name:mdh HAMAP MF_01517
Ordered Locus Names:TBFG_11265
OrganismMycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]
Taxonomic identifier336982 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP MF_01517 SAAS SAAS001252

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP MF_01517 RuleBase RU000422 SAAS SAAS010945

Subunit structure

Homodimer By similarity. HAMAP MF_01517 SAAS SAAS010945

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family. HAMAP MF_01517 RuleBase RU000421

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 187NAD By similarity HAMAP MF_01517
Nucleotide binding130 – 1323NAD By similarity HAMAP MF_01517

Sites

Active site1881Proton acceptor By similarity HAMAP MF_01517
Binding site931Substrate By similarity HAMAP MF_01517
Binding site991Substrate By similarity HAMAP MF_01517
Binding site1061NAD By similarity HAMAP MF_01517
Binding site1131NAD By similarity HAMAP MF_01517
Binding site1321Substrate By similarity HAMAP MF_01517
Binding site1631Substrate By similarity HAMAP MF_01517

Sequences

Sequence LengthMass (Da)Tools
A5WLR9 [UniParc].

Last modified July 28, 2009. Version 1.
Checksum: 0B142659617F9C2C

FASTA32934,223
        10         20         30         40         50         60 
MSASPLKVAV TGAAGQIGYS LLFRLASGSL LGPDRPIELR LLEIEPALQA LEGVVMELDD 

        70         80         90        100        110        120 
CAFPLLSGVE IGSDPQKIFD GVSLALLVGA RPRGAGMERS DLLEANGAIF TAQGKALNAV 

       130        140        150        160        170        180 
AADDVRVGVT GNPANTNALI AMTNAPDIPR ERFSALTRLD HNRAISQLAA KTGAAVTDIK 

       190        200        210        220        230        240 
KMTIWGNHSA TQYPDLFHAE VAGKNAAEVV NDQAWIEDEF IPTVAKRGAA IIDARGASSA 

       250        260        270        280        290        300 
ASAASATIDA ARDWLLGTPA DDWVSMAVVS DGSYGVPEGL ISSFPVTTKG GNWTIVSGLE 

       310        320 
IDEFSGGRID KSTAELADER SAVTELGLI

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000717 Genomic DNA. Translation: ABR05608.1.
RefSeqYP_001287210.1. NC_009565.1.

3D structure databases

ProteinModelPortalA5WLR9.
SMRA5WLR9. Positions 4-329.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5WLR9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5221942.
GenomeReviewsGene locus TBFG_11265 in contig CP000717_GR.
KEGGmtf:TBFG_11265.
PATRIC18133462. VBIMycTub9078_1390.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMANKIQISL.
ProtClustDBPRK05442.

Family and domain databases

HAMAPMF_01517. Malate_dehydrog_2.
[Tree]
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.90.110.10. lact_mal_DH. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00024.
PANTHERPTHR23382. MDH_SF1. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. Lactate_DH/Glyco_hydro_4_C. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5WLR9_MYCTF
AccessionPrimary (citable) accession number: A5WLR9
Entry history
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: December 14, 2011
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info