A5WLB7 (A5WLB7_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Pantothenate kinase HAMAP MF_00215 RuleBase RU003530
EC=2.7.1.33 HAMAP MF_00215 RuleBase RU003530

Alternative name(s):
Pantothenic acid kinase HAMAP MF_00215

Gene names

Name:	coaA HAMAP MF_00215
Ordered Locus Names:	TBFG_11113

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215 RuleBase RU003530 SAAS SAAS004566
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215 RuleBase RU003530 SAAS SAAS004566
Subcellular location	Cytoplasm By similarity HAMAP MF_00215 RuleBase RU003530 SAAS SAAS004566.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family. HAMAP MF_00215 RuleBase RU003530

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis HAMAP MF_00215 RuleBase RU003530 SAAS SAAS004566
Cellular component	Cytoplasm HAMAP MF_00215 RuleBase RU003530 SAAS SAAS004566
Ligand	ATP-binding HAMAP MF_00215 RuleBase RU003528 SAAS SAAS004566 Nucleotide-binding
Molecular function	Kinase HAMAP MF_00215 RuleBase RU003528 SAAS SAAS004566 EMBL ABR05456.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP pantothenate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	97 – 104	8	ATP By similarity HAMAP MF_00215

Sequences

	Sequence		Length	Mass (Da)
	A5WLB7 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: F075B543AE75788D	FASTA	312	35,657
	10 20 30 40 50 60 MSRLSEPSPY VEFDRRQWRA LRMSTPLALT EEELVGLRGL GEQIDLLEVE EVYLPLARLI 70 80 90 100 110 120 HLQVAARQRL FAATAEFLGE PQQNPDRPVP FIIGVAGSVA VGKSTTARVL QALLARWDHH 130 140 150 160 170 180 PRVDLVTTDG FLYPNAELQR RNLMHRKGFP ESYNRRALMR FVTSVKSGSD YACAPVYSHL 190 200 210 220 230 240 HYDIIPGAEQ VVRHPDILIL EGLNVLQTGP TLMVSDLFDF SLYVDARIED IEQWYVSRFL 250 260 270 280 290 300 AMRTTAFADP ESHFHHYAAF SDSQAVVAAR EIWRTINRPN LVENILPTRP RATLVLRKDA 310 DHSINRLRLR KL

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR05456.1.
RefSeq	YP_001287058.1. NC_009565.1.
3D structure databases
ProteinModelPortal	A5WLB7.
SMR	A5WLB7. Positions 5-312.
ModBase	Search...
Protein-protein interaction databases
STRING	A5WLB7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5221790.
GenomeReviews	Gene locus TBFG_11113 in contig CP000717_GR.
KEGG	mtf:TBFG_11113.
PATRIC	18133129. VBIMycTub9078_1224.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EVYLPLS.
ProtClustDB	PRK05439.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5WLB7_MYCTF

Accession

Primary (citable) accession number: A5WLB7

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)