A5WKW7 (A5WKW7_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase HAMAP MF_00473
Short name=GPI HAMAP MF_00473
EC=5.3.1.9 HAMAP MF_00473

Alternative name(s):
Phosphoglucose isomerase HAMAP MF_00473
Phosphohexose isomerase HAMAP MF_00473

Gene names

Name:	pgi HAMAP MF_00473
Ordered Locus Names:	TBFG_10963

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	553 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473 RuleBase RU000612 SAAS SAAS023096
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473 RuleBase RU000612 SAAS SAAS023096
Subcellular location	Cytoplasm By similarity HAMAP MF_00473 RuleBase RU003642.
Sequence similarities	Belongs to the GPI family. HAMAP MF_00473 RuleBase RU000612

Ontologies

Keywords
Biological process	Gluconeogenesis HAMAP MF_00473 RuleBase RU000612 SAAS SAAS023096 Glycolysis HAMAP MF_00473 RuleBase RU000612 SAAS SAAS023096
Cellular component	Cytoplasm HAMAP MF_00473 SAAS SAAS023096
Molecular function	Isomerase HAMAP MF_00473 RuleBase RU000612 SAAS SAAS023096 EMBL ABR05306.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: HAMAP glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	388	1	By similarity HAMAP MF_00473
	Active site	514	1	By similarity HAMAP MF_00473

Sequences

	Sequence		Length	Mass (Da)
	A5WKW7 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: FB57DFFD16386AE4	FASTA	553	59,974
	10 20 30 40 50 60 MTSAPIPDIT ATPAWDALRR HHDQIGNTHL RQFFADDPGR GRELTVSVGD LYIDYSKHRV 70 80 90 100 110 120 TRETLALLID LARTAHLEER RDQMFAGVHI NTSEDRAVLH TALRLPRDAE LVVDGQDVVT 130 140 150 160 170 180 DVHAVLDAMG AFTDRLRSGE WTGATGKRIS TVVNIGIGGS DLGPVMVYQA LRHYADAGIS 190 200 210 220 230 240 ARFVSNVDPA DLIATLADLD PATTLFIVAS KTFSTLETLT NATAARRWLT DALGDAAVSR 250 260 270 280 290 300 HFVAVSTNKR LVDDFGINTD NMFGFWDWVG GRYSVDSAIG LSLMTVIGRD AFADFLAGFH 310 320 330 340 350 360 IIDRHFATAP LESNAPVLLG LIGLWYSNFF GAQSRTVLPY SNDLSRFPAY LQQLTMESNG 370 380 390 400 410 420 KSTRADGSPV SADTGEIFWG EPGTNGQHAF YQLLHQGTRL VPADFIGFAQ PLDDLPTAEG 430 440 450 460 470 480 TGSMHDLLMS NFFAQTQVLA FGKTAEEIAA DGTPAHVVAH KVMPGNRPST SILASRLTPS 490 500 510 520 530 540 VLGQLIALYE HQVFTEGVVW GIDSFDQWGV ELGKTQAKAL LPVITGAGSP PPQSDSSTDG 550 LVRRYRTERG RAG

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR05306.1.
RefSeq	YP_001286908.1. NC_009565.1.
3D structure databases
ProteinModelPortal	A5WKW7.
ModBase	Search...
Protein-protein interaction databases
STRING	A5WKW7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5221637.
GenomeReviews	Gene locus TBFG_10963 in contig CP000717_GR.
KEGG	mtf:TBFG_10963.
PATRIC	18132780. VBIMycTub9078_1053.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NSLPAWT.
ProtClustDB	PRK00179.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

A5WKW7_MYCTF

Accession

Primary (citable) accession number: A5WKW7

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)