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Protein

Elongation factor Tu

Gene

tuf

Organism
Mycobacterium tuberculosis (strain F11)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi83 – 875GTPUniRule annotation
Nucleotide bindingi138 – 1414GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMTUB336982:GH7I-707-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:TBFG_10699Imported
ORF Names:P426_00712Imported
OrganismiMycobacterium tuberculosis (strain F11)Imported
Taxonomic identifieri336982 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000000660: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Proteomic databases

PRIDEiA5WK53.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi336982.TBFG_10699.

Structurei

3D structure databases

ProteinModelPortaliA5WK53.
SMRiA5WK53. Positions 5-395.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiHYRPQLF.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5WK53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAKFQRTK PHVNIGTIGH VDHGKTTLTA AITKVLHDKF PDLNETKAFD
60 70 80 90 100
QIDNAPEERQ RGITINIAHV EYQTDKRHYA HVDAPGHADY IKNMITGAAQ
110 120 130 140 150
MDGAILVVAA TDGPMPQTRE HVLLARQVGV PYILVALNKA DAVDDEELLE
160 170 180 190 200
LVEMEVRELL AAQEFDEDAP VVRVSALKAL EGDAKWVASV EELMNAVDES
210 220 230 240 250
IPDPVRETDK PFLMPVEDVF TITGRGTVVT GRVERGVINV NEEVEIVGIR
260 270 280 290 300
PSTTKTTVTG VEMFRKLLDQ GQAGDNVGLL LRGVKREDVE RGQVVTKPGT
310 320 330 340 350
TTPHTEFEGQ VYILSKDEGG RHTPFFNNYR PQFYFRTTDV TGVVTLPEGT
360 370 380 390
EMVMPGDNTN ISVKLIQPVA MDEGLRFAIR EGGRTVGAGR VTKIIK
Length:396
Mass (Da):43,594
Last modified:July 28, 2009 - v1
Checksum:i85F9012F364692FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000717 Genomic DNA. Translation: ABR05042.1.
JLDC01000002 Genomic DNA. Translation: KBJ37606.1.
RefSeqiYP_001286644.1. NC_009565.1.

Genome annotation databases

EnsemblBacteriaiABR05042; ABR05042; TBFG_10699.
KBJ37606; KBJ37606; P426_00712.
GeneIDi5221367.
KEGGimtf:TBFG_10699.
PATRICi18132190. VBIMycTub9078_0764.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000717 Genomic DNA. Translation: ABR05042.1.
JLDC01000002 Genomic DNA. Translation: KBJ37606.1.
RefSeqiYP_001286644.1. NC_009565.1.

3D structure databases

ProteinModelPortaliA5WK53.
SMRiA5WK53. Positions 5-395.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi336982.TBFG_10699.

Proteomic databases

PRIDEiA5WK53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR05042; ABR05042; TBFG_10699.
KBJ37606; KBJ37606; P426_00712.
GeneIDi5221367.
KEGGimtf:TBFG_10699.
PATRICi18132190. VBIMycTub9078_0764.

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiHYRPQLF.
OrthoDBiEOG6R5C6X.

Enzyme and pathway databases

BioCyciMTUB336982:GH7I-707-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F11Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F11Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F11Imported.

Entry informationi

Entry nameiA5WK53_MYCTF
AccessioniPrimary (citable) accession number: A5WK53
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: March 4, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.