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A5WK35 (A5WK35_MYCTF) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA-directed RNA polymerase subunit beta HAMAP-Rule MF_01321
Short name=RNAP subunit beta HAMAP-Rule MF_01321
EC=2.7.7.6 HAMAP-Rule MF_01321
Alternative name(s):
RNA polymerase subunit beta HAMAP-Rule MF_01321
Transcriptase subunit beta HAMAP-Rule MF_01321
Gene names
Name:rpoB HAMAP-Rule MF_01321
Ordered Locus Names:TBFG_10681
OrganismMycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP] EMBL ABR05024.1
Taxonomic identifier336982 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex ›

Protein attributes

Sequence length1178 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates By similarity. HAMAP-Rule MF_01321 RuleBase RU000432

Catalytic activity

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). HAMAP-Rule MF_01321

Subunit structure

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription By similarity. HAMAP-Rule MF_01321 RuleBase RU000433

Sequence similarities

Belongs to the RNA polymerase beta chain family. HAMAP-Rule MF_01321 RuleBase RU000434

Sequences

Sequence LengthMass (Da)Tools
A5WK35 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 8C393FEFB0B8CCF1

FASTA1,178129,891
        10         20         30         40         50         60 
MLEGCILADS RQSKTAASPS PSRPQSSSNN SVPGAPNRVS FAKLREPLEV PGLLDVQTDS 

        70         80         90        100        110        120 
FEWLIGSPRW RESAAERGDV NPVGGLEEVL YELSPIEDFS GSMSLSFSDP RFDDVKAPVD 

       130        140        150        160        170        180 
ECKDKDMTYA APLFVTAEFI NNNTGEIKSQ TVFMGDFPMM TEKGTFIING TERVVVSQLV 

       190        200        210        220        230        240 
RSPGVYFDET IDKSTDKTLH SVKVIPSRGA WLEFDVDKRD TVGVRIDRKR RQPVTVLLKA 

       250        260        270        280        290        300 
LGWTSEQIVE RFGFSEIMRS TLEKDNTVGT DEALLDIYRK LRPGEPPTKE SAQTLLENLF 

       310        320        330        340        350        360 
FKEKRYDLAR VGRYKVNKKL GLHVGEPITS STLTEEDVVA TIEYLVRLHE GQTTMTVPGG 

       370        380        390        400        410        420 
VEVPVETDDI DHFGNRRLRT VGELIQNQIR VGMSRMERVV RERMTTQDVE AITPQTLINI 

       430        440        450        460        470        480 
RPVVAAIKEF FGTSQLSQFM DQNNPLSGLT HKRRLLALGP GGLSRERAGL EVRDVHPSHY 

       490        500        510        520        530        540 
GRMCPIETPE GPNIGLIGSL SVYARVNPFG FIETPYRKVV DGVVSDEIVY LTADEEDRHV 

       550        560        570        580        590        600 
VAQANSPIDA DGRFVEPRVL VRRKAGEVEY VPSSEVDYMD VSPRQMVSVA TAMIPFLEHD 

       610        620        630        640        650        660 
DANRALMGAN MQRQAVPLVR SEAPLVGTGM ELRAAIDAGD VVVAEESGVI EEVSADYITV 

       670        680        690        700        710        720 
MHDNGTRRTY RMRKFARSNH GTCANQCPIV DAGDRVEAGQ VIADGPCTDD GEMALGKNLL 

       730        740        750        760        770        780 
VAIMPWEGHN YEDAIILSNR LVEEDVLTSI HIEEHEIDAR DTKLGAEEIT RDIPNISDEV 

       790        800        810        820        830        840 
LADLDERGIV RIGAEVRDGD ILVGKVTPKG ETELTPEERL LRAIFGEKAR EVRDTSLKVP 

       850        860        870        880        890        900 
HGESGKVIGI RVFSREDEDE LPAGVNELVR VYVAQKRKIS DGDKLAGRHG NKGVIGKILP 

       910        920        930        940        950        960 
VEDMPFLADG TPVDIILNTH GVPRRMNIGQ ILETHLGWCA HSGWKVDAAK GVPDWAARLP 

       970        980        990       1000       1010       1020 
DELLEAQPNA IVSTPVFDGA QEAELQGLLS CTLPNRDGDV LVDADGKAML FDGRSGEPFP 

      1030       1040       1050       1060       1070       1080 
YPVTVGYMYI MKLHHLVDDK IHARSTGPYS MITQQPLGGK AQFGGQRFGE MECWAMQAYG 

      1090       1100       1110       1120       1130       1140 
AAYTLQELLT IKSDDTVGRV KVYEAIVKGE NIPEPGIPES FKVLLKELQS LCLNVEVLSS 

      1150       1160       1170 
DGAAIELREG EDEDLERAAA NLGINLSRNE SASVEDLA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000717 Genomic DNA. Translation: ABR05024.1.
RefSeqYP_001286626.1. NC_009565.1.

3D structure databases

ProteinModelPortalA5WK35.
ModBaseSearch...

Protein-protein interaction databases

STRING336982.TBFG_10681.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABR05024; ABR05024; TBFG_10681.
GeneID5221349.
KEGGmtf:TBFG_10681.
PATRIC18132148. VBIMycTub9078_0743.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0085.
HOGENOMHOG000218611.
KOK03043.
ProtClustDBPRK00405.

Enzyme and pathway databases

BioCycMTUB336982:GH7I-668-MONOMER.

Family and domain databases

Gene3D2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 1 hit.
HAMAPMF_01321. RNApol_bact_RpoB.
InterProIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERPTHR20856. PTHR20856. 1 hit.
PTHR20856:SF3. PTHR20856:SF3. 1 hit.
PfamPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 1 hit.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsTIGR02013. rpoB. 1 hit.
PROSITEPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5WK35_MYCTF
AccessionPrimary (citable) accession number: A5WK35
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info