A5WJE6 (A5WJE6_MYCTF) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme HAMAP MF_00664
EC=4.1.1.65 HAMAP MF_00664

Gene names

Name:	psd HAMAP MF_00664
Ordered Locus Names:	TBFG_10442

Organism

Mycobacterium tuberculosis (strain F11) [Complete proteome] [HAMAP]

Taxonomic identifier

336982 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664 SAAS SAAS003817
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00664 SAAS SAAS003817
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664 SAAS SAAS003817
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily. HAMAP MF_00664

Ontologies

Keywords
Biological process	Phospholipid biosynthesis HAMAP MF_00664 SAAS SAAS003817
Ligand	Pyruvate HAMAP MF_00664 SAAS SAAS003817
Molecular function	Decarboxylase HAMAP MF_00664 SAAS SAAS003817 Lyase
PTM	Zymogen HAMAP MF_00664
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Site	199 – 200	2	Cleavage (non-hydrolytic) By similarity HAMAP MF_00664
Amino acid modifications
	Modified residue	200	1	Pyruvic acid (Ser) By similarity HAMAP MF_00664

Sequences

	Sequence		Length	Mass (Da)
	A5WJE6 [UniParc]. Last modified July 28, 2009. Version 1. Checksum: EA9C65BD41A579B3	FASTA	231	24,260
	10 20 30 40 50 60 MARRPRPDGP QHLLALVRSA VPPVHPAGRP FIAAGLAIAA VGHRYRWLRG TGLLAAAACA 70 80 90 100 110 120 GFFRHPQRVP PTRPAAIVAP ADGVICAIDS AAPPAELSMG DTPLPRVSIF LSILDAHVQR 130 140 150 160 170 180 APVSGEVIAV QHRPGRFGSA DLPEASDDNE RTSVRIRMPN GAEVVAVQIA GLVARRIVCD 190 200 210 220 230 AHVGDKLAIG DTYGLIRFGS RLDTYLPAGA EPIVNVGQRA VAGETVLAEC R

References

[1]

"The complete genome sequence of Mycobacterium tuberculosis F11." Birren B., Lander E., Galagan J., Devon K., Nusbaum C., Borowsky M.L., Grabherr M., Mauceli E., Brockman W., Young S., LaButti K., Pushparaj V., Sykes S., Baldwin J., Fitzgerald M., Bloom T., Zimmer A., Settipalli S. , Shea T., Arachchi H., Macdonald P., Abouelleil A., Lui A., Priest M., Berlin A., Gearin G., Brown A., Aftuck L., Bessette D., Allen N., Lubonja R., Lokyitsang T., Matthews C., Dunbar C., Benamara M., Nguyen T., Negash T., DeCaprio D., Crawford M., Koehrsen M., Engels R., Montgomery P., Pearson M., Howarth C., Kodira C., Zeng Q., Yandava C., O'Leary S., Alvarado L., Victor T., Murray M. Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000717 Genomic DNA. Translation: ABR04785.1.
RefSeq	YP_001286387.1. NC_009565.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A5WJE6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5221106.
GenomeReviews	Gene locus TBFG_10442 in contig CP000717_GR.
KEGG	mtf:TBFG_10442.
PATRIC	18131611. VBIMycTub9078_0479.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	IFMSVFN.
ProtClustDB	PRK05305.
Family and domain databases
HAMAP	MF_00664. PS_decarb_type3. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase-related. [Graphical view]
KO	K01613.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5WJE6_MYCTF

Accession

Primary (citable) accession number: A5WJE6

Entry history

Integrated into UniProtKB/TrEMBL:	July 28, 2009
Last sequence update:	July 28, 2009
Last modified:	December 14, 2011
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)