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Protein

Superoxide dismutase [Cu-Zn]

Gene

TBFG_10437

Organism
Mycobacterium tuberculosis (strain F11)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. superoxide dismutase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

CopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciMTUB336982:GH7I-441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:TBFG_10437Imported
ORF Names:P426_00443Imported
OrganismiMycobacterium tuberculosis (strain F11)Imported
Taxonomic identifieri336982 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000000660: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi336982.TBFG_10437.

Structurei

3D structure databases

ProteinModelPortaliA5WJE1.
SMRiA5WJE1. Positions 70-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
KOiK04565.
OMAiYNQTNGT.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5WJE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPKPADHRNH AAVSTSVLSA LFLGAGAALL SACSSPQHAS TVPGTTPSIW
60 70 80 90 100
TGSPAPSGLS GHDEESPGAQ SLTSTLTAPD GTKVATAKFE FANGYATVTI
110 120 130 140 150
ATTGVGKLTP GFHGLHIHQV GKCEPNSVAP TGGAPGNFLS AGGHYHVPGH
160 170 180 190 200
TGTPASGDLA SLQVRGDGSA MLVTTTDAFT MDDLLSGAKT AIIIHAGADN
210 220 230 240
FANIPPERYV QVNGTPGPDE TTLTTGDAGK RVACGVIGSG
Length:240
Mass (Da):23,844
Last modified:July 28, 2009 - v1
Checksum:iAFC08C0B302B84FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000717 Genomic DNA. Translation: ABR04780.1.
JLDC01000002 Genomic DNA. Translation: KBJ37341.1.
RefSeqiYP_001286382.1. NC_009565.1.

Genome annotation databases

EnsemblBacteriaiABR04780; ABR04780; TBFG_10437.
KBJ37341; KBJ37341; P426_00443.
GeneIDi5221101.
KEGGimtf:TBFG_10437.
PATRICi18131599. VBIMycTub9078_0473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000717 Genomic DNA. Translation: ABR04780.1.
JLDC01000002 Genomic DNA. Translation: KBJ37341.1.
RefSeqiYP_001286382.1. NC_009565.1.

3D structure databases

ProteinModelPortaliA5WJE1.
SMRiA5WJE1. Positions 70-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi336982.TBFG_10437.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABR04780; ABR04780; TBFG_10437.
KBJ37341; KBJ37341; P426_00443.
GeneIDi5221101.
KEGGimtf:TBFG_10437.
PATRICi18131599. VBIMycTub9078_0473.

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
KOiK04565.
OMAiYNQTNGT.
OrthoDBiEOG6K13RS.

Enzyme and pathway databases

BioCyciMTUB336982:GH7I-441-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR018152. SOD_Cu/Zn_BS.
IPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS00332. SOD_CU_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: F11Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F11Imported.
  3. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: F11Imported.

Entry informationi

Entry nameiA5WJE1_MYCTF
AccessioniPrimary (citable) accession number: A5WJE1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 28, 2009
Last sequence update: July 28, 2009
Last modified: February 4, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.